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28 results on '"Kasuga, Masato"'

2. [113th Scientific Meeting of the Japanese Society of Internal Medicine: Presidential Lecture: Panel Discussion: Obesity Disease and Metabolic Syndrome -from Pathophysiology to Concept of Management: Introduction].

Author

Matsuzawa Y and Kasuga M

Subjects
Humans, Internal Medicine, Japan, Societies, Medical, Metabolic Syndrome diagnosis, Metabolic Syndrome metabolism, Metabolic Syndrome physiopathology, Metabolic Syndrome therapy, Obesity diagnosis, Obesity metabolism, Obesity physiopathology, Obesity therapy
Published
2016

7. [Diabetes susceptibility genes].

Author

Kasuga M

Subjects
Genome-Wide Association Study, Humans, Diabetes Mellitus, Type 2 genetics, Genetic Predisposition to Disease
Abstract

Type 2 diabetes mellitus is a complex polygenic disorder in which common genetics variants interact with environmental factors. Genome-wide association study(GWAS) revealed more than 10 diabetes susceptibility loci for type 2 diabetes mellitus including SNPs in KCNQ1, which was first identified in Japanese by two independent Japanese groups. However, these variants identified by GWAS showed low O.R. (odds ratio) such as 1.1-1.5 suggesting low penetrance of these variants. Diabetes mellitus is also caused by a mutation in one gene such as glucokinase and HNF-1 alpha, which showed high penetrance. Therefore, next challenge will be to identify low-frequency variants with intermediate penetrance, which may be associated with diabetes mellitus.

Published
2009

8. [Obesity and insulin resistance].

Author

Tamori Y and Kasuga M

Subjects
Humans, Insulin Resistance physiology, Obesity physiopathology
Abstract

The worldwide epidemic of obesity is a serious threat to public health, because obesity results in insulin resistance, which leads to metabolic syndrome. Obesity is determined by both adipocyte size (adipocyte hypertrophy) and adipocyte number (adipocyte hyperplasia). Recent studies have begun to clarify the mechanism which regulates the size and number of adipocytes. In addition, chronic inflammation in insulin sensitive tissues receives much attention as the mediator between obesity and insulin resistance. In particular, excess triacylglycerol storage in adipocytes induces macrophage infiltration into adipose tissues, which results in inflammation and alters the expression and secretion of various adipokines. Inflammation pathway is also activated in liver. In addition, myeloid cells are tightly involved in inflammation in adipose tissues and liver. Inflammation in these tissues results in systemic insulin resistance. Intervention which decreases inflammation may be useful treatment for insulin resistance.

Published
2009

10. [Adverse effects of alpha-glucosidase inhibitors].

Author

Sakaguchi K and Kasuga M

Subjects
1-Deoxynojirimycin adverse effects, 1-Deoxynojirimycin analogs & derivatives, Acarbose adverse effects, Drug Interactions, Humans, Hypoglycemia chemically induced, Imino Pyranoses adverse effects, Inositol adverse effects, Inositol analogs & derivatives, Digestive System Diseases chemically induced, Enzyme Inhibitors adverse effects, Glycoside Hydrolase Inhibitors, Hyperammonemia chemically induced, Hypoglycemic Agents adverse effects
Published
2007

12. [Molecular basis of metabolic syndrome].

Author

Tamori Y and Kasuga M

Subjects
Adipose Tissue metabolism, Animals, Cardiovascular Diseases etiology, Female, Humans, Hyperlipidemias physiopathology, Hypertension physiopathology, Macrophage Migration-Inhibitory Factors metabolism, Male, Metabolic Syndrome diagnosis, Metabolic Syndrome metabolism, Mice, Obesity physiopathology, Adiponectin blood, Insulin Resistance, Metabolic Syndrome physiopathology
Published
2007

14. [Insulin action and its regulatory mechanisms].

Author

Noguchi T and Kasuga M

Subjects
Adipose Tissue physiology, Animals, Humans, Liver physiology, Metabolic Syndrome etiology, Mice, Muscle, Skeletal physiology, Signal Transduction physiology, Insulin physiology
Published
2006

15. [Rabson-Mendenhall syndrome].

Author

Kishimoto M and Kasuga M

Subjects
Abnormalities, Multiple, Diagnosis, Differential, Humans, Hypertrophy, Insulin-Like Growth Factor I therapeutic use, Leptin therapeutic use, Mutation, Prognosis, Recombinant Proteins therapeutic use, Syndrome, Diabetes Mellitus diagnosis, Diabetes Mellitus genetics, Insulin Resistance, Pineal Gland pathology, Receptor, Insulin genetics
Published
2006

16. [Insulin signaling and pathophysiology of type 2 diabetes mellitus].

Author

Ogawa W and Kasuga M

Subjects
Adipocytes metabolism, Adiponectin physiology, Antigens, CD physiology, Brain physiology, Cell Division, Diabetes Mellitus, Type 2 physiopathology, Dyslipidemias complications, Glucose metabolism, Humans, Insulin metabolism, Insulin Receptor Substrate Proteins, Insulin Resistance physiology, Insulin Secretion, Insulin-Secreting Cells cytology, Insulin-Secreting Cells metabolism, Liver metabolism, Muscle, Skeletal metabolism, Phosphatidylinositol 3-Kinases physiology, Phosphoproteins physiology, Receptor, Insulin physiology, Diabetes Mellitus, Type 2 etiology, Insulin physiology, Signal Transduction physiology
Abstract

The pathophysiology of type 2 diabetes is characterized by defects in insulin action and in insulin secretion. Metabolic actions of insulin are mediated by the insulin receptor/IRS/PI 3-kinase signaling pathway in insulin's target organs including the liver, skeletal muscle and adipose tissue. Recent evidence suggests that insulin action in the brain also plays an important role in the regulation of glucose metabolism in the liver. Insulin signaling in pancreatic beta cells appears to regulate glucose-induced insulin secretion. Although the mechanism how insulin resistance develops is not fully understood, dysregulation of fatty acid metabolism, abnormalities of the function and the secretion of adipokines, as well as the increase in stress signaling might contribute to the development of insulin resistance.

Published
2006

17. [Insulin receptor gene].

Author

Ogawa W and Kasuga M

Subjects
Animals, Disease Models, Animal, Glucose Transporter Type 4 genetics, Glucose Transporter Type 4 physiology, Humans, Insulin Resistance genetics, Mice, Mice, Transgenic, Mutation, Polymorphism, Genetic, Receptor, Insulin physiology, Signal Transduction genetics, Hypertension genetics, Receptor, Insulin genetics
Published
2006

18. [Search for type 2 diabetes susceptibility genes].

Author

Hirota Y and Kasuga M

Subjects
Adiponectin genetics, Amyloid genetics, Calpain genetics, Drug Design, Genetic Testing, Genome, Human genetics, Hepatocyte Nuclear Factor 4 genetics, Humans, Islet Amyloid Polypeptide, PPAR gamma genetics, Pharmacogenetics, Polymorphism, Single Nucleotide, Potassium Channels, Inwardly Rectifying genetics, Diabetes Mellitus, Type 2 genetics, Genetic Predisposition to Disease genetics
Published
2005

19. [Role of hyperglycemia in the development of diabetic microangiopathy].

Author

Miyata S and Kasuga M

Subjects
Animals, Apoptosis, Deoxyglucose analogs & derivatives, Deoxyglucose metabolism, Fructose metabolism, Glucose metabolism, Glycation End Products, Advanced metabolism, Hexosamines metabolism, Humans, Mitogen-Activated Protein Kinases physiology, Polymers metabolism, Postprandial Period, Protein Kinase C metabolism, Signal Transduction, Diabetic Angiopathies etiology, Hyperglycemia complications
Published
2005

20. [Etiologies of impaired glucose tolerance and impaired fasting glycemia].

Author

Ohara T and Kasuga M

Subjects
Age Factors, Environment, Glucose Intolerance genetics, Glucose Tolerance Test, Humans, Infant, Low Birth Weight, Infant, Newborn, Insulin metabolism, Insulin Resistance, Insulin Secretion, Islets of Langerhans metabolism, Life Style, Racial Groups, Sex Factors, Fasting blood, Glucose Intolerance etiology
Published
2005

21. [Disorder of carbohydrate metabolism].

Author

Nakamura T, Sakaue H, and Kasuga M

Subjects
Humans, Insulin Resistance, Carbohydrate Metabolism, Metabolic Syndrome metabolism
Abstract

The worldwide epidemic of type 2 diabetes and impaired glucose tolerance is a crucial health problem. Since disorder of carbohydrate metabolism causes arteriosclerosis in combination with other metabolic abnormalities such as hypertension, hyperlipidemia and obesity, it has now been recognized as one manifestation of the metabolic syndrome, a condition characterized by insulin resistance. In this article, we summarize the current our knowledge on how disorder of carbohydrate metabolism influences insulin resistance and arteriosclerosis in part of metabolic syndrome.

Published
2004

22. [Mechanism of insulin action and diabetes mellitus].

Author

Ogawa W and Kasuga M

Subjects
Adipocytes cytology, Adipocytes metabolism, Animals, Carbohydrate Metabolism, Cardiovascular Physiological Phenomena, Cell Differentiation, Cell Division, Eating drug effects, Humans, Liver metabolism, Muscle, Skeletal metabolism, Phosphatidylinositol 3-Kinases physiology, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Phosphoproteins physiology, Phosphoric Monoester Hydrolases physiology, Protein Biosynthesis, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatases physiology, Receptor, Insulin chemistry, Receptor, Insulin physiology, Signal Transduction physiology, Triglycerides metabolism, Diabetes Mellitus etiology, Insulin physiology
Published
2003

23. [Obesity in patients with diabetes].

Author

Ohara T and Kasuga M

Subjects
Adrenergic Agonists therapeutic use, Anti-Obesity Agents therapeutic use, Behavior Therapy, Diet, Reducing, Enzyme Inhibitors therapeutic use, Exercise Therapy, Gastric Bypass, Humans, Hypoglycemic Agents therapeutic use, Lactones therapeutic use, Lipase antagonists & inhibitors, Orlistat, Serotonin Receptor Agonists therapeutic use, Diabetes Mellitus physiopathology, Diabetes Mellitus therapy, Obesity
Published
2002

24. [Lipodystrophic diabetes].

Author

Sakaue H and Kasuga M

Subjects
Adiponectin, Animals, Disease Models, Animal, Genes, Dominant, Genes, Recessive, Heterotrimeric GTP-Binding Proteins genetics, Humans, Lamin Type A genetics, Leptin physiology, Leptin therapeutic use, Mice, Mutation, Prognosis, Proteins physiology, Proteins therapeutic use, Receptors, Retinoic Acid genetics, Retinoid X Receptors, Transcription Factors genetics, Diabetes Mellitus, Lipoatrophic genetics, Diabetes Mellitus, Lipoatrophic physiopathology, Diabetes Mellitus, Lipoatrophic therapy, GTP-Binding Protein gamma Subunits, Intercellular Signaling Peptides and Proteins
Published
2002

25. [Molecular basis for the development of type 2 diabetes mellitus].

Author

Kasuga M

Subjects
3-Phosphoinositide-Dependent Protein Kinases, AMP-Activated Protein Kinase Kinases, Animals, Apoptosis, Endoplasmic Reticulum physiology, Fatty Acids, Nonesterified metabolism, Humans, Insulin Resistance, Insulin Secretion, Islets of Langerhans physiology, Lipid Peroxidation, Phosphatidylinositol 3-Kinases physiology, Phosphoproteins physiology, Protein Kinases metabolism, Protein Serine-Threonine Kinases physiology, Receptor, Insulin physiology, Signal Transduction physiology, Diabetes Mellitus, Type 2 etiology, Insulin metabolism
Published
2002

26. [Insulin action: its variety and diversity].

Author

Ogawa W and Kasuga M

Subjects
Adipose Tissue metabolism, Animals, Central Nervous System, Energy Metabolism, Glucose metabolism, Glycogen biosynthesis, Humans, Islets of Langerhans, Kidney metabolism, Liver metabolism, Muscle, Skeletal metabolism, Receptor, Insulin physiology, Triglycerides biosynthesis, Vasodilation, Insulin physiology
Published
2002

27. [The mechanism of insulin receptor activation upon insulin binding].

Author

Uchida T and Kasuga M

Subjects
Animals, Humans, Insulin Receptor Substrate Proteins, Phosphoproteins physiology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatases physiology, Receptor, Insulin chemistry, Insulin metabolism, Receptor, Insulin metabolism
Published
2002

28. [Mutations in the insulin receptor gene].

Author

Hashiramoto M and Kasuga M

Subjects
Abnormalities, Multiple, Acanthosis Nigricans etiology, Diabetes Mellitus etiology, Diagnosis, Differential, Growth Disorders etiology, Hirsutism etiology, Humans, Hyperinsulinism etiology, Insulin Resistance genetics, Prognosis, Receptor, Insulin biosynthesis, Syndrome, Mutation, Receptor, Insulin genetics
Published
2002

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