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1. [A short tandem repeat polymorphism in the inducible nitric oxide synthase gene in Chinese population].

Author

Lü X, Lu P, Xing RY, Sun QY, Qiu ZW, Han L, Zhou XB, and Zheng XF

Subjects
Adolescent, Adult, Alleles, Base Sequence, China ethnology, Female, Genotype, Humans, Male, Middle Aged, Molecular Sequence Data, Nitric Oxide Synthase Type II, White People, Nitric Oxide Synthase genetics, Polymorphism, Genetic, Tandem Repeat Sequences
Abstract

Polymorphism of the (CCTTT)n repeat, a short tandem repeats (STR) located in promoter region of the inducible nitric oxide synthase (iNOS) gene, was analyzed in a total of 316 Chinese healthy subjects. Twelve alleles and forty-nine genotypes were identified. Three alleles that had not been reported previously, namely 17-repeats, 18-repeats and 19-repeats, were found in Chinese population. Mendelian inheritance of the allele in a family composed of three generations was determined. Some of the observed allele frequency of this STR locus in Chinese differed significantly from that of Caucasians in England.

Published
2002

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