Search

Your search keyword '"Leukemia, Myelogenous, Chronic, BCR-ABL Positive physiopathology"' showing total 6 results
Start Over Descriptor "Leukemia, Myelogenous, Chronic, BCR-ABL Positive physiopathology" Language japanese
6 results on '"Leukemia, Myelogenous, Chronic, BCR-ABL Positive physiopathology"'

1. [Chronic myelogenous leukemia].

Author

Yoshida C

Subjects
Drug Resistance, Neoplasm drug effects, Early Detection of Cancer, Humans, Immunotherapy methods, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive physiopathology, Treatment Outcome, Antineoplastic Agents therapeutic use, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Published
2013

4. [Chronic myelogenous leukemia].

Author

Niikura H

Subjects
Diagnosis, Differential, Fusion Proteins, bcr-abl genetics, Hematopoietic Stem Cell Transplantation, Humans, Philadelphia Chromosome, Prognosis, T-Lymphocytes immunology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive etiology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive physiopathology
Published
2000

5. [Clinical study of chronic myelogenous leukemia].

Author

Shibata A

Subjects
Blast Crisis prevention & control, Bone Marrow Transplantation, Busulfan therapeutic use, Granulocytes physiology, Humans, Hydroxyurea therapeutic use, Interferon-alpha therapeutic use, Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive physiopathology
Published
1993

6. [Abnormalities in regulation system of granulopoiesis].

Author

Koike K, Sawai N, Okumura N, Shiohara M, Amano Y, Nakahata T, and Komiyama A

Subjects
Anemia, Aplastic physiopathology, Cells, Cultured, Hematopoietic Cell Growth Factors physiology, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive physiopathology, Neutropenia physiopathology, Stem Cell Factor, Cytokines physiology, Granulocytes physiology, Hematopoiesis physiology
Abstract

We studied the effects of several cytokines on the development of granulocyte-macrophage (GM) progenitors using the serum-deprived culture. SCF plays an important role in the GM-CSF- or IL-3-dependent production of neutrophils and macrophages. In vitro colony assay also suggests an increase in sensitivity of GM progenitors to cytokines (GM-CSF, IL-3, G-CSF and/or SCF) in a patient with juvenile chronic myelogenous leukemia. A high level of serum IFN-gamma was associated with leukopenia and thrombocytopenia in a patient with hemophagocytic syndrome. Based on the evidence that IFN-gamma significantly inhibited the proliferation of GM progenitors, IFN-gamma-mediated suppression was suggested as one of the mechanisms causing cytopenia. In patients with aplastic anemia and neutropenia, an increase of serum G-CSF levels was observed when neutrophils decreased remarkably in number. However, the serum SCF levels were constant in these patients. A failure of SCF to enhance colony growth in some patients with aplastic anemia implies qualitative abnormalities of hematopoietic progenitors.

Published
1993

Catalog

Books, media, physical & digital resources
See catalog results