39 results on '"Mitani, M."'
Search Results
2. [Total Glossolaryngectomy of an Advanced Oropharyngeal and Tongue Squamous-Cell Carcinoma: A 29-Case Series Study].
- Author
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Hama T, Sasaki T, Kawabata K, Mitani MH, Yonekawa H, Fukushima H, Shimbashi W, Seto A, Kamiyama R, and Ebina A
- Subjects
- Alcohol Drinking adverse effects, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Recurrence, Carcinoma, Squamous Cell surgery, Laryngectomy, Oropharyngeal Neoplasms surgery, Tongue Neoplasms surgery
- Abstract
We report herein on 29 patients with advanced oropharyngeal and tongue squamous-cell carcinoma who underwent a total glossolaryngectomy at the Cancer Institute Hospital of the JFCR between July 2005 and June 2013. In this study, we tried to evaluate associations between several variables of the primary tumor and prognosis in these 29 patients. The cause-specific 5-year survival rate with the Kaplan-Meier method was 45% in all patients. Tumor recurrence occurred in 15 patients. Four patients had recurrence in the primary site, 11 patients in neck lymph nodes or in the lungs or bone. The multivariate analysis revealed that the number of neck lymph node metastases, age and alcohol drinking were poor prognostic markers for patients undergoing a total glossolaryngectomy. Cause-specific survival was compared between patients with salvage surgery and initial surgery using Kaplan-Meier survival curves with log-rank tests. There was no significant association with survival (log-rank test: p = 0.13). The overall local control rate was 69% in all patients. Regarding salvage surgery, 9 of 16 patients had no recurrence in the primary site or neck lymph nodes. The limitations of this study include the small number of patients especially regarding the prognosis study and may have included a selection bias regarding undergoing a total glossolaryngectomy.
- Published
- 2015
- Full Text
- View/download PDF
3. [Case report; a case of Hashimoto's thyroiditis mimicking dementia with Lewy bodies (DLB)].
- Author
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Nishida K, Tone K, Yamasaki H, Nishimoto K, Kawamoto K, Futamura N, Mitani M, Funakawa I, and Jinnai K
- Subjects
- Aged, Hashimoto Disease drug therapy, Hormones therapeutic use, Humans, Male, Treatment Outcome, Dementia diagnosis, Diagnosis, Differential, Hashimoto Disease diagnosis, Lewy Body Disease diagnosis
- Published
- 2014
- Full Text
- View/download PDF
4. [Posterior spinal cord infarction presenting Brown-Séquard syndrome].
- Author
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Kuga A, Mitani M, Funakawa I, and Jinnai K
- Subjects
- Evoked Potentials, Somatosensory, Female, Humans, Infarction diagnosis, Infarction physiopathology, Magnetic Resonance Imaging, Middle Aged, Spinal Cord physiopathology, Brown-Sequard Syndrome etiology, Infarction complications, Spinal Cord blood supply
- Abstract
We report a 56 year-old-woman with spinal cord infarction. She experienced left-sided girdle pain without precipitating symptoms and she developed monoparesis of her left leg and urinary retention. She also presented the segmental loss of total sensations in the Th10-11 area of the left trunk, the disturbance of position and vibration senses in the left leg and the disturbance of pain and temperature senses in the right leg. T2-weighted MR imagings showed high signal intensity lesion in the left half of the spinal posterior column at Th9-10 vertebral levels. Somatosensory evoked potentials confirmed that the loss of position and vibration senses was unilateral. Though she became able to walk with canes two months later, her sensory disturbance showed no improvement. This is a rare case of unilateral posterior spinal cord infarction presenting Brown-Séquard syndrome.
- Published
- 2005
5. [Transient left ventricular apical ballooning, "Takotsubo" cardiomyopathy, in an amyotrophic lateral sclerosis patient on long-term respiratory support].
- Author
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Mitani M, Funakawa I, and Jinnai K
- Subjects
- Amyotrophic Lateral Sclerosis therapy, Cardiomyopathies diagnostic imaging, Echocardiography, Electrocardiography, Female, Humans, Middle Aged, Amyotrophic Lateral Sclerosis complications, Cardiomyopathies etiology, Respiration, Artificial
- Abstract
A 52-year-old woman developed dysarthria and dysphagia in April 1997, then experienced progressive weakness in her arms and legs several months later, which led to a diagnosis of amyotrophic lateral sclerosis (ALS). In October 1998, the patient was placed on respiratory support and thereafter in a bedridden state. On December 6, 2004, the patient suddenly fell into cardiogenic shock. An echocardiographic examination demonstrated extensive akinesis of the left ventricle together with the hyperkinetic constraction of the cardiac base. The left ventricular akinesis completely returned to normal by December 13. Based on our these results and her clinical course, we made a diagnosis of "Takotsubo" cardiomyopathy. This is the first case reported to have developed this condition in an ALS patient on long-term respiratory support. Physicians should be aware of the potential risk of developing "Takotsubo" cardiomyopathy in respirator-dependent ALS patients.
- Published
- 2005
6. [Hyperfractionated radiotherapy with concurrent chemotherapy for advanced esophageal cancer].
- Author
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Asakura H, Takashima H, Yokoe K, Togami T, Mitani M, Kiuchi T, Hosokawa N, Seo H, and Ohkawa M
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Cisplatin administration & dosage, Combined Modality Therapy, Deglutition Disorders etiology, Drug Administration Schedule, Esophageal Neoplasms mortality, Female, Fluorouracil administration & dosage, Humans, Hypothyroidism etiology, Infusions, Intravenous, Leukopenia chemically induced, Male, Middle Aged, Remission Induction, Retrospective Studies, Survival Rate, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Dose Fractionation, Radiation, Esophageal Neoplasms drug therapy, Esophageal Neoplasms radiotherapy
- Abstract
The clinical efficacy and safety of hyperfractionated radiotherapy with concurrent chemotherapy were studied retrospectively in patients with primary advanced esophageal cancer. The subjects were 31 patients who were treated with hyperfractionated radiotherapy and concurrent chemotherapy in our institution between 1990 and 2001. The chemoradiotherapy consisted of cisplatin 70-80 mg/m2 on day one, and continuous infusion of 5-fluorouracil 700-800 mg/m2/24 hours on days 1 to 3, with concurrent hyperfractionated radiotherapy (57.6-72 Gy). Complete remission (CR) was observed in 17 cases, and partial response in 13 cases (response rate: 96. 7%). Three-year survival rate and 5-year survival rate were 35.5% and 26.3%, respectively. Grade 3/4 hematological toxicities included leukocytes in 7 patients (22.6%), hemoglobin in 6 patients (19.4%), and platelets in 4 patients (12.9%). Grade 3 dysphagia-esophageal related to radiation was observed in 3 patients (9.7%). Late toxicities occurred with the following incidences: hypothyroidism in 2 patients, benign esophageal strictures in 2 patients, pericardial effusion in 8 patients, and pleural effusion in 8 patients. The results suggest that combined chemotherapy and hyperfractionated radiotherapy is an effective and well-tolerated regimen.
- Published
- 2005
7. [A case of esophageal achalasia followed by Parkinson's disease].
- Author
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Mitani M, Kawamoto K, Funakawa I, and Jinnai K
- Subjects
- Aged, Female, Humans, Esophageal Achalasia complications, Parkinson Disease complications
- Abstract
In 1992, a 63 year-old woman complained of dysphagia and chest pain, and was diagnosed with esophageal achalasia. Three years later, she developed resting tremor, cog-wheel rigidity, and retro-pulsion, and was diagnosed with Parkinson's disease and given appropriate medication. Several years later, intractable vomitting and aspiration pneumonia developed, and the lower esophageal sphincter was dilated using a pneumatic balloon dilator under gastroscopic guidance in 2004. That procedure improved her symptoms and the esophageal dilation was visualized on chest CT images. Herein, we report this rare case of esophageal achalasia followed by Parkinson's disease and discuss the relationship between the two diseases.
- Published
- 2005
8. [Detection of intracellular unimolecules using nucleic acid amplification technology].
- Author
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Yasumasa M and Chiaki K
- Subjects
- Sensitivity and Specificity, Cells chemistry, Nucleic Acid Amplification Techniques methods, Nucleic Acids isolation & purification
- Published
- 2004
9. [Three dimensional conformal radiotherapy (3D-CRT) for localized prostate cancer under field adjustment with implanted gold markers: early clinical outcome].
- Author
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Taketa S, Shimada O, Tsukuda F, Inui M, Kuwata Y, Kakehi Y, Mitani M, and Takashima H
- Subjects
- Aged, Androgen Antagonists therapeutic use, Combined Modality Therapy, Drug Implants, Gold administration & dosage, Humans, Laparoscopy, Lymph Node Excision, Male, Middle Aged, Prostatic Neoplasms drug therapy, Prostatic Neoplasms surgery, Treatment Outcome, Prostatic Neoplasms radiotherapy, Radiotherapy, Conformal methods
- Abstract
Three dimensional conformal radiotherapy (3D-CRT) for localized prostate cancer under field adjustment with gold marker implantation was performed according to the treatment strategy based on the clinical risk factors to the patients who chose external beam radiotherapy. The treatment strategy contains indications for laparoscopic staging lymphadenectomy and neoadjuvant combined androgen blockade (CAB). This protocol was applied to 19 patients at Kagawa University Hospital from July 2001 to December 2003. The patients were divided into high-risk group (n=14): T3-4N0M0 or PSA > or = 20 ng/ml or Gleason sum > or = 8 or suspicious node, and low-risk group (n=5): T1c-2bN0M0 and PSA < 20 ng/ml and Gleason sum < or = 7 and no suspicious nodes. Basically, high-risk patients underwent laparoscopic staging lymphadenectomy prior to radiotherapy. One of the 14 patients had a positive node and underwent endocrine therapy. The high-risk group received neoadjuvant CAB for 3 to 4 months, followed by gold marker implantation. One patient chose endocrine therapy at this point. Low-risk patients underwent marker implantation without endocrine therapy. Every patient successfully completed planned irradiation. The changes of prostate volume and serum PSA after neoadjuvant CAB were significant [28.7 ml to 15.7 ml (p=0.004) and 53.9 ng/ml to 1.4 ng/ml (p=0.023), respectively]. Only one patient in the high-risk group had biochemical failure. No grade 3 or 4 adverse events occurred in NCI-CTC grading. The analysis of gravity center migration of the implanted gold markers in the first 8 patients showed that the planned safety margin might not be wide enough to avoid neighboring organ irradiation. These results suggested that 3D-CRT under field adjustment with implanted gold markers contributes to both higher efficacy and lower morbidity.
- Published
- 2004
10. [Quantitative study of 99mTc-technegas SPECT for ventilatory impairment in pulmonary emphysema--regional distribution: correlation of SPECT with pulmonary function test].
- Author
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Satoh K, Mitani M, Yamamoto Y, Nishiyama Y, and Ohkawa M
- Subjects
- Humans, Forced Expiratory Volume, Lung diagnostic imaging, Lung physiopathology, Pulmonary Emphysema diagnostic imaging, Pulmonary Emphysema physiopathology, Radiopharmaceuticals, Sodium Pertechnetate Tc 99m, Technetium, Tomography, Emission-Computed, Single-Photon
- Abstract
99mTc-Technegas scintigraphy is used for evaluation of abnormality of ventilation in pulmonary emphysema. Although the abnormality of ventilation distribution is very easy to find, there is not an objective index. The evaluation is subjective and different by each radiologist. It was also difficult to compare each cases and the clinical course in the same case. The present study for quantitative evaluation has proved that excellent correlations is obtained between the mean voxel values of the lung and stage classification. Furthermore, a correlation is observed between the mean and FEV1.0%. These deta indicate that quantitative analysis of SPECT seem to be useful to classify the clinical stage and compare the each cases. And respiratory function decreases as much as chronic pulmonary emphysema exists in the lower lung field.
- Published
- 2003
11. [A case of NARP (neurogenic muscle weakness, ataxia, and retinitis pigmentosa) with a T-to-C point mutation at nt 8993 of mitochondrial DNA].
- Author
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Mitani M, Jinnai K, Takahashi K, Koide R, and Tsuji S
- Subjects
- Adult, Humans, Male, Muscle Weakness genetics, Syndrome, Ataxia genetics, DNA, Mitochondrial genetics, Mitochondrial Myopathies genetics, Point Mutation, Retinitis Pigmentosa genetics
- Abstract
We report a case of NARP with a T-to-C point mutation at nt 8993 of mitochondrial DNA. A 37-year old man with mild mental retardation, retinitis pigmentosa, and clonic-tonic seizure was admitted to our hospital. The neurological examination revealed scanning speech, dystonic neck turning to the left side, and pyramidal tract signs. Serum-, CSF-lactate and pyruvate level were slightly elevated. Brain MRI findings showed cerebral atrophy, cerebellar cortical atrophy accompanied with dilation of forth ventricle, and high intensity lesions in the bilateral lenticular nuclei on T2 weighted images. Nucleotide sequence analysis of the mitochondrial DNA in the leukocytes demonstrated a T-to-C point mutation at nt 8993. To our knowledge, this is the first report of a Japanese patient with NARP associated with the T-to-C mutation at nt 8993 of mt DNA. Mitochondrial DNA analysis should be considered in the differential diagnosis of patients with retinitis pigmentosa and various neurological signs.
- Published
- 2000
12. [Proposed mechanism of action of metalloendopeptidase-F in the treatment of patients with chronic hepatitis B or C infection].
- Author
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Fujisaki S, Fujisaki T, Yoshida J, Fujisaki Y, Mitani M, Nakamura M, and Otake N
- Subjects
- Animals, Cytokines metabolism, Cytokines physiology, Hepatitis B, Chronic immunology, Hepatitis C, Chronic immunology, Humans, Liver metabolism, Liver physiology, Liver Regeneration, Low Density Lipoprotein Receptor-Related Protein-1, Macrophages immunology, Metalloendopeptidases metabolism, Metalloendopeptidases pharmacology, Receptors, Immunologic metabolism, Receptors, Immunologic physiology, T-Lymphocytes, Cytotoxic immunology, Transforming Growth Factor beta antagonists & inhibitors, alpha-Macroglobulins metabolism, alpha-Macroglobulins physiology, Hepatitis B, Chronic therapy, Hepatitis C, Chronic therapy, Metalloendopeptidases therapeutic use
- Abstract
Chronic hepatitis B and C virus infections have been characterized by the pathophysiological features with a high incidence of progression to cirrhosis and development of hepatocellular carcinoma. The viral persistence produced by escape mutations from virus-specific cytotoxic T lymphocytes (CTL) response may lead to upregulation of delayed-type hypersensitivity immune response, which causes hepatic tissue damage through non specific macrophage activation and CTL response and promotes pathogenesis of hepatic fibrosis. In a preliminary clinical study, a novel metalloendopeptidase-F (MEP-F) has been shown to be effective in the treatment of patients with either chronic hepatitis B or C infection. Oral administration of MEP-F resulted in a significant reduction of the serum levels of HBs antigen and HCV RNA and improvement in the liver function abnormalities. However, the mechanism of action of MEP-F is not yet well understood. There are accumulating evidences showing an important role of alpha 2-macroglobulin-proteinase complexes in regulatory mechanisms of immune response and repairing within impaired and inflammatory tissues. In this article, reviewing the pharmacological and biological properties of alpha 2-macroglobulin-proteinase complexes, the mechanism of anti-viral effect of MEP-F is examined based on the clinical findings. It is indicated that alpha 2-macroglobulin-MEP-F complexes may induce macrophage/Kuppfer cell activation and proliferation through binding their receptors on the cells and activating signaling cascades, which enhance both anti-viral specific and nonspecific immune responses. alpha 2-Macroglobulin-MEP-F complexes may also augment cellular immunity and hepatic regeneration by neutralizing the immunosuppressive and fibrogenic activities of transforming growth factor-beta.
- Published
- 2000
13. [A case of successful thromobolytic therapy in a patient with cerebral embolism during angiography].
- Author
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Uesaka T, Inamura T, Kawamura T, Ono H, Hirakawa Y, Mitani M, and Fukui M
- Subjects
- Humans, Intracranial Embolism etiology, Male, Middle Aged, Angiography adverse effects, Intracranial Embolism drug therapy, Thrombolytic Therapy, Urokinase-Type Plasminogen Activator administration & dosage
- Abstract
We report a case of successful thromobolytic therapy in a patient with cerebral embolism during angiography. A 57 year-old male lost his consciousness during angiography. His neurologic symptoms were semi-comatose and right oculomotor palsy. According to these symptoms, we estimated the lesion in the right midbrain. Immediately after we denied a cerebral hemorrhage by computed tomography, we infused 60,000 u of urokinase intravenously within an hour from the onset followed by diffusion weighted magnetic resonance imaging (DW-MRI). DW-MRI showed hyper-intense lesion in the midbrain. We sequentially performed thrombolytic therapy with urokinase by selective cerebral angiography within three hours from the onset. His symptoms gradually resolved, but his consciousness was still confused state. His all neurologic symptom completely resolved in the next day after hyperbaric oxygenation therapy.
- Published
- 1999
14. [Quantitative study of 99mTc-Technegas SPECT for ventilatory impairment in pulmonary emphysema].
- Author
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Mitani M, Satoh K, Takahashi K, Kobayashi T, Yamamoto Y, Nishiyama Y, Ohkawa M, Katoh T, and Hosokawa N
- Subjects
- Humans, Pulmonary Edema physiopathology, Respiratory Function Tests, Pulmonary Edema diagnostic imaging, Sodium Pertechnetate Tc 99m, Tomography, Emission-Computed, Single-Photon
- Abstract
99mTc-Technegas scintigraphy is used to evaluate ventilation abnormalities in patients with pulmonary emphysema. Although abnormalities of ventilation distribution are easy to find, no objective index exits. Evaluation is subjective and differs with each radiologist. Thus, it is difficult to compare cases and the clinical course in the same case. The present study for quantitative evaluation demonstrated an excellent correlations between mean voxel values of the lung and stage classification. Furthermore, a correlation was observed between the mean and FEV1.0%. These findings indicate that the quantitative analysis of SPECT data is useful for classifying clinical stage and comparing cases.
- Published
- 1999
15. [Digital filing system for medical image data].
- Author
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Mitani M, Mitani T, and Natori H
- Subjects
- Algorithms, Electronic Data Processing, Expert Systems, Filing methods, Image Processing, Computer-Assisted, Signal Processing, Computer-Assisted
- Abstract
To establish practical, effective medical digital image filing systems, various problems remain to be solved. The authors focused on 2 such problems of great importance: image data compression and standard specifications for digital data storage. From a variety of image compression algorithms now available, 2D-Color Doppler image compression was clinically investigated using the Joint Photographic Expert Group (JPEG) method. In low grade compression, the images decompressed showed no significant alterations in image quality, however, in higher grades of compression attained through irreversible coding in the JPEG method, the images showed subtle but significant alterations: emergence of 2 kinds of artifact, i.e., borderline-artifact produced in the DCT procedures and pseudo color spots. The reproducibility of colors was found to be altered by changing the quantization table in the JPEG procedure. It was thought necessary to choose a proper quantization table and examine the DC coefficients (number of pixels) in the DCT procedure to attain practical 2D-Color Doppler image compression by the JPEG method. Although attempts in Japan are being made to establish common standards for electronic data storage, based on MEDIS, in an effort to promote standardization there are many problems to be solved before practical use is possible. To ensure common availability as required by the technical standards, it is necessary to organize minimum-required specifications into common standards and make them open to the public.
- Published
- 1997
16. [Septal structure of incomplete interlobar fissures of the lung].
- Author
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Satoh K, Sato A, Kobayashi T, Sasaki M, Mitani M, Takahashi K, Nakano S, and Tanabe M
- Subjects
- Humans, Lung ultrastructure, Lung pathology
- Abstract
We describe the anatomy of incomplete interlobar fissures with and without septal structures. Twenty-eight fused areas in specimens obtained during 21 autopsies were examined histologically. In 12 of the 28 fused areas, there was a mixture of septal structures with and without defects. In the remaining 16, there were some septal structures. Septal structures consisted of inner layers from both lobes. These results suggest that linear shadows at interlobar fissures on computed tomography do not necessarily reflect complete interlobar fissures. Assessment of incomplete interlobar fissure is important with regard to collateral ventilation and pulmonary disease processes.
- Published
- 1996
17. [Comparison between high-resolution computed tomography and 99mTc-technegas SPECT pulmonary emphysema].
- Author
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Nakano S, Satoh K, Takahashi K, Mitani M, Kobayashi T, Seo H, Kawase Y, Tanabe M, Fujita J, Yamaji Y, and Okada H
- Subjects
- Adult, Aged, Humans, Male, Middle Aged, Lung diagnostic imaging, Pulmonary Emphysema diagnostic imaging, Radiographic Image Enhancement, Sodium Pertechnetate Tc 99m, Technetium, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed
- Abstract
Scintigraphy with 99mTc-technegas was recently introduced for clinical imaging of lung ventilation. This method has been found to be useful in emergencies, to be more suitable for single photon emission computed tomography (SPECT) than other agents used in ventilation scintigraphy, and could reveal abnormalities in ventilation more easily than high resolusion computed tomography (HRCT) in pulmonary emphysema. We compared 99mTc-technegas SPECT with HRCT in six regions: the right upper, middle, and lower lobes, the left upper lobe, the lingula, and the left lower lobe, in 15 patients with pulmonary emphysema. Patients with centrilobular emphysema tended to show stronger changes in upper lobes than in lower lobes on both 99mTc-technegas SPECT and HRCT. Some regions showed no change on HRCT but various changes on 99mTc-SPECT. Patients with panlobular emphysema showed severe changes on 99mTc-SPECT in lower lung fields in which well-demarcated areas of low attenuation were not seen on HRCT. We conclude that 99mTc-SPECT is useful for detecting early changes and panlobular changes in pulmonary emphysema.
- Published
- 1996
18. [Radiologic-pathologic correlation between tumor edge and surrounding inherent structures in peripheral lung cancer].
- Author
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Kobayashi T, Satoh K, Kawase Y, Mitani M, Takahashi K, Nakano S, Seo H, and Tanabe M
- Subjects
- Adenocarcinoma diagnostic imaging, Adenocarcinoma pathology, Carcinoma, Large Cell diagnostic imaging, Carcinoma, Large Cell pathology, Carcinoma, Small Cell diagnostic imaging, Carcinoma, Small Cell pathology, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell pathology, Humans, Pulmonary Artery diagnostic imaging, Pulmonary Artery pathology, Radiography, Lung Neoplasms diagnostic imaging, Lung Neoplasms pathology
- Abstract
Purpose: To evaluate the radiologic-pathologic relationship between the tumor edge of peripheral lung cancers and surrounding normal structures., Materials and Methods: Tissue samples from 16 lung cancers with diameters less than 2 cm were examined: 7 adenocarcinomas, 5 squamous cell carcinomas, 2 small cell carcinomas, 1 large cell carcinoma, and 1 that had metastasized to the lung. Inflation-fixed lung specimens containing tumor tissue were sliced to a thickness of 2 mm: The tumor edge of each section was traced under a stereomicroscope and its relationship to marginal structure, including bronchi, pulmonary arteries, and pulmonary veins containing interlobular septa, was analyzed. The tumor edge and marginal structures were classified into four types: Type 1, clear margin formed by marginal structures; Type 2, tumor involving the marginal structures; Types 3 and 4, marginal structures penetrating the tumor with and without a notch, respectively., Results: Type 1 was found in 23 of 47 pulmonary arteries (49%), 23 of 49 bronchi (47%), and 12 of 31 pulmonary veins or interlobular septa (39%). Type 2 was found in 11% (14/127), Type 3 in 15% (19/127) and Type 4 in 28% (36/127) of marginal structures. Type 1 was common in all histological types of carcinomas studied., Conclusion: In small peripheral lung cancers, the tumor edge sometimes has a clear margin formed by surrounding structures such as interlobular septa. This can make it difficult to differentiate benign from malignant lesions.
- Published
- 1996
19. [MR angiography in intrathoracic masses: evaluation of the superior vena cava, its major branches and their relation to the mass].
- Author
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Mitani M
- Subjects
- Adult, Aged, Female, Humans, Lung Neoplasms blood supply, Lung Neoplasms diagnosis, Male, Middle Aged, Phlebography, Thoracic Neoplasms blood supply, Tomography, X-Ray Computed, Magnetic Resonance Angiography, Thoracic Neoplasms diagnosis, Vena Cava, Superior pathology
- Abstract
MR angiography (MRA) of the thorax was evaluated in six healthy volunteers and 48 patients with an intrathoracic mass potentially infiltrating to the superior vena cava and/or its major branches. It was also compared with CT, spin echo MRI and X-ray venography. Three methods were used for MRA: sequential 2D-TOF MRA with presaturation band over the heart, 3D-MRA with bolus administration of Gd-DTPA in a single breath-hold and sequential 2D-TOF MRA with administration of Gd-DTPA. The major vessels themselves and their relation to the mass were clearly visualized on MRA in all volunteers and patients. Since original MRA demonstrated these vessels more clearly than projection MRA in our series, we considered that interpretation of MRA should be based mainly on original MRA. MRA generally could visualize the vessels as well as the other imaging modalities, and was sometimes superior to them. In conclusion, MRA is a non-invasive and effective method for the evaluation of major vessels and their relation to the mass in patients with an intrathoracic mass.
- Published
- 1995
20. [Differential diagnosis of solitary pulmonary nodules by computerized statistical analysis using CT number].
- Author
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Mitani M, Satoh K, Tachikawa A, Takashima H, Ohkawa M, and Tanabe M
- Subjects
- Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Regression Analysis, Solitary Pulmonary Nodule classification, Solitary Pulmonary Nodule pathology, Image Processing, Computer-Assisted, Lung diagnostic imaging, Solitary Pulmonary Nodule diagnostic imaging, Tomography, X-Ray Computed
- Abstract
There have been previous reports on the differentiation of benign pulmonary nodules from malignant ones using CT number. However, most of the nodules were without calcification, and diagnosis could be made only in limited cases. In the present study we established new multiple variables such as relative high density over the 75th percentile, inner gradient number (inner irregular rate), edge gradient number (edge irregular rate) and increased area rate (IAR). They are automatically calculated from CT data by computer. These variables are transformed into relative values, enabling comparisons of nodules without a standard reference phantom. With IAR, pulmonary nodules were classified into three types: type 1 (IAR 1.0-1.4), a high-density solid mass with well-defined margin; type 2 (IAR 1.4-2.0) between type 1 and type 3; and type 3 (IAR > 2.0) a low-density infiltrated mass with ill-defined margin. We studied 52 cases with solitary pulmonary nodules, whose diagnoses were confirmed either histologically or on follow-up. There were 34 benign nodules and 18 primary lung cancers. Using step-wise multiple regression with three variables, 42 of 52 cases were correctly diagnosed. Twenty-four of 28 type 1 cases and all 14 of type 2 cases were correctly diagnosed. This computer analysis is considered to be useful in distinguishing between benign and malignant solitary pulmonary nodules.
- Published
- 1995
21. [Comparison of 99mTc-technegas scintigraphy and high resolution CT in pulmonary emphysema].
- Author
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Satoh K, Tanabe M, Nakano S, Nishiyama Y, Takahashi K, Kobayashi T, Kawase Y, Mitani M, Ohkawa M, and Fujita J
- Subjects
- Aged, Humans, Male, Middle Aged, Pulmonary Emphysema diagnostic imaging, Smoking, Pulmonary Emphysema diagnosis, Radiographic Image Enhancement, Sodium Pertechnetate Tc 99m, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed methods
- Abstract
This study was undertaken to assess the usefulness of technetium-99m technegas scintigraphy axial images (technegas) compared with high resolution CT (HRCT) in 12 patients with pulmonary emphysema. All patients were male adult and heavy smokers and their mean age was 65. All patients inhaled 505 MBq technegas in several tidal volume breaths in the supine position without breath holding. SPECT imaging was performed by a Picker model Prism 2000. HRCT was performed after technegas. The technegas images showed different degree of changes from areas of heterogeneity to hot spots or defects. In emphysema, HRCT images showed low attenuation areas varying in size and number. In 4 of 12 patients, the degree of abnormal findings on technegas increased according to the degree of abnormal findings on HRCT. In the remaining 8 patients, however, more detailed findings were shown by technegas than by HRCT. There was no patients in which HRCT showed a greater changes than on technegas. HRCT can demonstrate low attenuation areas, even less than 5 mm in diameter. Moreover previous reports showed that aerosol inhalation would also demonstrate the airway disease. Assessment of the degree of involvement revealed by both methods indicated the superiority of technegas over HRCT. We conclude that technegas can represent the ventilation involvement easily more than HRCT in pulmonary emphysema.
- Published
- 1995
22. [Chronic inflammatory demyelinating polyneuropathy associated with chronic liver disease due to type B and type C hepatitis virus].
- Author
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Ohyama T, Okiyama R, Yamada M, Mitani M, Tamaki M, Endo M, and Kubo M
- Subjects
- Chronic Disease, Demyelinating Diseases pathology, Female, Humans, Liver pathology, Liver Cirrhosis pathology, Middle Aged, Polyneuropathies pathology, Sural Nerve pathology, Demyelinating Diseases etiology, Hepatitis B complications, Hepatitis C complications, Liver Cirrhosis complications, Polyneuropathies etiology
- Abstract
A patient with chronic inflammatory demyelinating polyneuropathy (CIDP) associated with type B and type C hepatitis virus infection is reported. A 54-year-old female who had a blood transfusion at the age of 31 years was diagnosed as a carrier of hepatitis B virus at the age of 43. Liver dysfunction was first noted in 1987 and gradually grew worse year by year. Beginning in early June 1992, the patients general fatigue became worse, her serum GOT and GPT levels became elevated, and she complained of a tingling sensation in her arms and legs. Neurological examination revealed moderate sensory disturbance of the glove-and-stocking type in all of her extremities. Deep tendon reflexes were all diminished. Hepatitis C antibody was detected in the serum at this time. On June 12, 1993, progression of her sensory disturbance was found to be associated with generalized muscle weakness. Cerebrospinal fluid studies showed increased protein without pleocytosis. Motor nerve conduction studies revealed marked prolongation of terminal latencies, reduction of conduction velocities, and abnormal temporal dispersion of the motor potentials. No sensory potentials could be evoked at any of the sites stimulated. Sural nerve biopsy showed segmental demyelination and severe loss of large myelinated fibers as well as some onion bulb formation. A diagnosis of CIDP was made. Treatment with corticosteroids was started, but there was little improvement in neurological function. The liver dysfunction progressed further and ultimately the patient died of hepatic failure. An autopsy demonstrated liver cirrhosis, but no malignant tumors were evident.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1995
23. [anorexia nervosa; an association with certain types of soft tissue emphysema].
- Author
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Satoh K, Kawase Y, Kobayashi T, Mitani M, Tanabe M, Tsuuchi Y, and Seo H
- Subjects
- Adolescent, Female, Humans, Anorexia Nervosa complications, Mediastinal Emphysema etiology, Pulmonary Emphysema etiology, Subcutaneous Emphysema etiology
- Abstract
A 17-year-old female with anorexia nervosa developed pneumomediastinum, subcutaneous emphysema, retroperitoneal emphysema, interstitial pulmonary emphysema and epidural emphysema (epidural emphysema; air between the dura mater and the vertebral arch). She had no history of bronchial asthma. The mechanism was presumed to be weakness of the alveolar wall due to malnutrition, leading to rupture of alveoli, followed by air entering the interstitium and dissecting along perivascular sheaths (interstitial pulmonary emphysema) into the mediastinum. A further increase in mediastinal pressure may bring about opening of the fascial planes along great vessels and allow air to penetrate into subcutaneous tissues and the spinal canal. These types of emphysema have been reported in bronchial asthma cases and in those on positive pressure breathing. To our knowledge, there are no previous reports of anorexia nervosa associated with these phenomena.
- Published
- 1994
24. [Acute encephalopathy with symmetrical lesions of the thalamus, the putamen and the cerebellum on magnetic resonance imaging].
- Author
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Okiyama R, Mitani M, Hayashi H, and Tanabe H
- Subjects
- Acute Disease, Adult, Brain Diseases diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed, Brain Diseases diagnosis, Cerebellum pathology, Putamen pathology, Thalamus pathology
- Abstract
A 19-year-old boy was admitted to our hospital because of impaired consciousness after experiencing fever and headaches for 7 days. The patient was in a deep coma or generalized convulsions, with retrocollis and decorticate posture. He never regained consciousness, remaining in an apallic state. The initial CSF pressure was 290 mm H2O, CSF cell count 18/3 mm3, protein 75 mg/100 ml, and sugar 74 mg/100 ml. There was no significant elevation in the viral titer in the serum or CSF. Plain CT on admission showed marked brain edema. MRI three months thereafter demonstrated symmetrical high intensity in the thalamus, the putamen and the cerebellum on both T1- and T2-weighted images, probably representing petechial bleeding. The lesions in the medial portion of the occipital lobes showed iso intensity on T1-weighted images and high intensity on T2-weighted images. These lesions were consistent with infarction of both posterior cerebral arteries, which may have been due to severe brain edema. The clinical and MRI findings were similar to those of patients with acute encephalopathy with low-density areas in the thalamus or bilateral striatal necrosis in childhood. To the best of our knowledge, there have been no reports of cases like ours in adults.
- Published
- 1994
25. [Percutaneous transhepatic gastrostomy with CT guidance in patients with partial gastrectomy].
- Author
-
Kanazawa S, Naomoto Y, Mitani M, Yasui K, Satoh S, Katoh K, Nakamura K, Togami I, and Hiraki Y
- Subjects
- Aged, Anastomosis, Surgical, Humans, Male, Reoperation, Stomach diagnostic imaging, Stomach Neoplasms diagnostic imaging, Gastrectomy, Gastrostomy methods, Stomach Neoplasms surgery, Tomography, X-Ray Computed
- Abstract
Percutaneous transhepatic gastrostomy was performed in two patients, one with partial gastrectomy and Billroth I anastomosis and one with esophageal reconstruction with subtotal stomach, in whom oral feeding was precluded. In both patients, percutaneous gastrostomy with fluoroscopic guidance was impossible since the gastric remnants were small, had a high subcostal position, and were overlain by the transverse colon, lung and left lobe of the liver. The only route available to avoid the overlying bowel and lung was the transhepatic approach. The gastric remnants were punctured with a 22-gauge PTC needle through the left lobe of the liver with CT guidance, and an 8 Fr. Cope-type catheter was fluoroscopically placed in the gastric remnant or the duodenum after tract dilatation over the guide wire. No complications occurred during or after the procedures, and the condition of both patients was greatly improved. Although gastrostomy in patients with partial gastrectomy is thought to be very difficult, percutaneous transhepatic gastrostomy with CT guidance is easy and may be safe since adhesion between the liver and gastric remnant can prevent massive hemorrhage or displacement of the catheters.
- Published
- 1993
26. [MR angiography of the lung using 3-dimensional imaging method].
- Author
-
Togami I, Mitani M, Kitagawa T, Katoh K, Joja I, Hiraki Y, and Kimura T
- Subjects
- Humans, Lung Neoplasms blood supply, Middle Aged, Lung blood supply, Lung pathology, Lung Neoplasms diagnosis, Magnetic Resonance Imaging methods
- Abstract
Three-Dimensional MR angiography (3D-MRA) of the lung was performed in 5 healthy volunteers and 14 patients with primary pulmonary cancer in the hilum, and compared with 2D-MRA. As 3D-MRA could be obtained with single breath holding after intravenous bolus injection of Gd-DTPA, pulmonary vessels of the hilum and peripheral zone were demonstrated more definitely than those of 2D-MRA. In all patients except one case, the relation between the tumor and pulmonary vessels was visualized more clearly by 3D-MRA than 2D-MRA. This technique is considered a non-invasive and effective method for evaluation of pulmonary vessels in the patient with hilar tumor.
- Published
- 1992
27. [Hepatic arteriography under temporary hepatic venous occlusion].
- Author
-
Kanazawa S, Douke T, Yasui K, Mitani M, Sato S, Ajiki M, Kohno Y, Kimoto S, and Hiraki Y
- Subjects
- Adult, Aged, Angiography, Female, Humans, Male, Middle Aged, Carcinoma, Hepatocellular diagnostic imaging, Hepatic Artery diagnostic imaging, Hepatic Veno-Occlusive Disease diagnostic imaging, Liver Neoplasms diagnostic imaging
- Abstract
Hepatic arteriography with and without temporary segmental hepatic vein occlusion was performed in 10 patients, five of whom had chronic liver injury. Hepatic arteriograms obtained during hepatic venous obstruction demonstrated significantly more peripheral and definite arterial branches in the occluded area and fewer peripheral branches in the non-occluded segment. A prolonged, dense hepatogram (sinusoidogram) showing hepatofugal opacification of the portal vein was obtained in the occluded area. Only one case with a large veno-venous anastomosis did not show these findings. Hepatic arteriograms in two cases with hepatocellular carcinoma provided clear visualization of peripheral portal branches that could act as efferent tumor vessels during regional temporary hepatic vein occlusion. Temporary hepatic venous occlusion may cause a sudden increase of hepatic arterial flow in the occluded area and transsinusoidal arterioportal communication there. This method can be useful for the diagnosis and arterial infusion or embolization therapy of hepatic diseases.
- Published
- 1992
28. [Clinical experience of continuous retrograde cerebral perfusion for assisted circulation during the surgical treatment of acute dissection of aorta: Stanford A type].
- Author
-
Nakano H, Shimakura T, Ihashi K, Sakamoto T, Hoshino K, Takeda M, Maejima F, Mitani M, Taguchi A, and Ichikawa Y
- Subjects
- Aged, Aorta, Thoracic, Assisted Circulation, Female, Humans, Male, Middle Aged, Aortic Dissection surgery, Aortic Aneurysm surgery, Cerebrovascular Circulation physiology, Heart Arrest, Induced, Perfusion
- Abstract
Surgical treatment of the dissection involving the ascending aorta or aortic arch represents one of the most complicated technical challenges. Recently continuous retrograde cerebral perfusion (CRCP) is sometimes applied in order to avoid cerebral complications. We compared two surgical groups, one of which was performed graft-replacement of ascending aorta using CRCP and another was utilized normograde cerebral circulation, about the technique of operation, total extracorporeal circulation (ECC) time, aortic clamp time, separate ECC time, total bleeding volume, and urination during operation. In the group using CRCP, separate ECC time was 53 min (mean), and intraoperative bleeding volume was only 1,170 ml. Good urination was obtained during operation. Postoperative courses were uneventful, and consciousness was smoothly and soon recovered. The new method of separate ECC has some advantages over the previously described methods, particularly for avoidance of cerebral complications. As it is not necessary to require dissecting, taping, and clamping of cephalic branches, operative procedure will be very simplified, easier and safer, leading to intraoperative bleeding is a fewer. It is our belief that this method should be widely applied in the operation of graft-replacement of ascending aorta or aortic arch in the near future.
- Published
- 1992
29. [A case of liver cirrhosis associated with chronic subdural hematoma and hepatic encephalopathy].
- Author
-
Tsuji H, Kashiwagi M, Ikeda K, Kawatoko T, Nomiyama K, Hasuo H, Murai K, Fujishima M, Hasuo K, and Mitani M
- Subjects
- Chronic Disease, Female, Humans, Middle Aged, Hematoma, Subdural etiology, Hepatic Encephalopathy etiology, Liver Cirrhosis complications
- Abstract
A 58-year-old male liver cirrhosis patient, who had a history of recurrent hepatic encephalopathy, was admitted to our hospital because of clouding of consciousness. He had an episode of recent head trauma. On admission, he was drowsy and exhibited flapping tremor, fetor hepaticus and ascites. Laboratory data showed an increase in blood ammonia level, and a decrease in peripheral thrombocytes, serum albumin and prothrombin value. A ratio of branched-chain to aromatic amino acids was reduced. Antibody against hepatitis C virus was positive. His electroencephalogram showed bilaterally large synchronous slow waves. He was treated with intravenous branched-chain amino acids, and recovered. Cranial computed tomography on day 9 demonstrated a crescent shaped area of low density in the right frontotempoparietal subdural region. He was diagnosed as chronic subdural hematoma, which was treated surgically. It has been suggested that chronic subdural hematomas develop as a complication of hemostatic deficiency due to liver cirrhosis.
- Published
- 1991
30. [Biochemical aspects of protease treatment in chronic inflammation].
- Author
-
Fujisaki S, Fujisaki Y, Yoshida J, Nakamura M, and Mitani M
- Subjects
- Animals, Chronic Disease, Intestinal Absorption, Pronase therapeutic use, Rabbits, Rats, Sinusitis drug therapy, Anti-Inflammatory Agents blood, Pronase blood, Sinusitis enzymology
- Published
- 1985
- Full Text
- View/download PDF
31. [Human yolk sac tumor of the thymus heterotransplanted into nude mice].
- Author
-
Takao S, Nishi M, Baba K, Arimura T, Maenohara S, Mitani M, Kaneko Y, Nomura H, and Suganuma T
- Subjects
- Adult, Animals, Carcinoembryonic Antigen analysis, Chorionic Gonadotropin blood, Humans, Male, Mesonephroma immunology, Mesonephroma ultrastructure, Mice, Mice, Nude, Neoplasm Transplantation, Thymus Neoplasms immunology, Thymus Neoplasms ultrastructure, alpha-Fetoproteins analysis, Mesonephroma pathology, Thymus Neoplasms pathology, Transplantation, Heterologous
- Abstract
A human yolk sac tumor of the thymus (YSK-1) was transplanted into athymic nude mice. Histological and ultrastructural investigations revealed that the YSK-1 tumor, even after serial transplantation in nude mice, characteristically displayed Schiller-Duval bodies, endodermal sinus structures and ultrastructural profiles, numerous microvilli, desmosome-like cell attachments, annulate lamellar structures, many lipid droplets and interspersed glycogen particles. Serological study by radioimmunoassay demonstrated AFP, CEA, HCG, alpha 1-AT and transferrin in the sera and cyst fluid of the tumor-bearing nude mice. Immunohistochemical investigation using the PAP method showed that the YSK-1 cells produced CEA, HCG, alpha 1-AT, transferrin as well as AFP. The increase in the level of AFP paralleled the increase in tumor size.
- Published
- 1983
32. [Micromethods for the electronmicroscopic observation of nucleic acids (author's transl)].
- Author
-
Egel-Mitani M
- Subjects
- Microscopy, Electron methods, Nucleic Acids
- Published
- 1974
33. [Antitumor activity of schizophyllan (SPG) against syngeneic ACI/N rat tumor, AMC-60 fibrosarcoma and BC-47 bladder cancer].
- Author
-
Mitani M, Arika T, Matsuo T, and Asano T
- Subjects
- Animals, Cells, Cultured, Cytotoxicity, Immunologic, Female, Fibrosarcoma immunology, Lymphocyte Activation drug effects, Neoplasm Transplantation, Rats, Rats, Inbred ACI, Sarcoma, Experimental immunology, Sarcoma, Experimental pathology, Sizofiran pharmacology, Urinary Bladder Neoplasms immunology, Fibrosarcoma pathology, Glycosaminoglycans therapeutic use, Sizofiran therapeutic use, Urinary Bladder Neoplasms pathology
- Abstract
The antitumor activity of schizophyllan (SPG) against syngeneic ACI/N rat tumor, AMC-60 fibrosarcoma and BC-47 bladder cancer was investigated. Intramuscular injection of SPG caused a marked suppression of AMC-60 tumor growth. Results obtained with cytotoxicity tests in vitro and lymphoblastogeneic response in vitro suggest the association of enhanced macrophage cytostasis and high reactivity of lymphoid cells with the resistance of the host to AMC-60 tumor. Moreover, SPG showed pronounced antitumor activity against BC-47 bladder cancer. The highest therapeutic effectiveness was obtained when SPG injection was started at an advanced stage of the tumor, 4 out of 15 rats treated being completely cured of cancer. Cytotoxicity tests in vitro and neutralization tests in vivo indicated the important role of cytotoxic lymphocytes as well as activated macrophages in the host defence mechanism against BC-47 cancer. This, taken together with the fact that the rats cured completely by SPG therapy acquired transplantation resistance to BC-47 cancer, shows that SPG may promote tumor immunity in the host.
- Published
- 1984
34. [Prediction of embolism in patient with mitral stenosis studied by two-dimensional echocardiography and blood coagulation tests].
- Author
-
Yasaka M, Miyatake K, Mitani M, Beppu S, Nagata S, Yamaguchi T, and Omae T
- Subjects
- Adult, Aged, Fibrin Fibrinogen Degradation Products analysis, Fibrinopeptide A analysis, Fibrinopeptide B analysis, Humans, Intracranial Embolism and Thrombosis etiology, Middle Aged, Mitral Valve Stenosis complications, Peptide Fragments analysis, Prognosis, Blood Coagulation Tests, Echocardiography, Doppler, Intracranial Embolism and Thrombosis diagnosis, Mitral Valve Stenosis diagnosis
- Published
- 1989
- Full Text
- View/download PDF
35. [Immunoblastic lymphadenopathy complicated by Epstein-Barr virus-positive primary brain lymphoma].
- Author
-
Yoshimoto S, Yamato K, Kitagawa T, Fujishita M, Mitani M, Yano S, Kubonishi I, Niiya K, Taguchi H, and Sonobe H
- Subjects
- Brain Neoplasms microbiology, Burkitt Lymphoma microbiology, Herpesvirus 4, Human isolation & purification, Humans, Immunoblastic Lymphadenopathy drug therapy, Male, Middle Aged, Brain Neoplasms complications, Burkitt Lymphoma complications, Immunoblastic Lymphadenopathy complications
- Published
- 1985
36. [Experimental study on immunochemotherapy using schizophyllan].
- Author
-
Mitani M, Iwano K, Arika T, and Kikuchi M
- Subjects
- Animals, Macrophage Activation drug effects, Male, Mammary Neoplasms, Experimental therapy, Mice, Mice, Inbred C3H, Mitomycin, Mitomycins administration & dosage, Plasmacytoma therapy, T-Lymphocytes drug effects, Zinostatin administration & dosage, Adjuvants, Immunologic administration & dosage, Glycosaminoglycans administration & dosage, Neoplasms, Experimental therapy, Sizofiran administration & dosage
- Abstract
Immunochemotherapy with schizophyllan (SPG) combined with chemotherapeutic agents was evaluated in two syngeneic tumor-C3H/He mouse systems. The administration of SPG alone caused a significant growth inhibition of MM 46 mammary carcinoma, the highest therapeutic effect being obtained by SPG given at the advanced stage of tumors. When combined with neocarzinostatin given 7-times every other day the simultaneous administration of SPG produced an optimal response to that therapy. In X-5563 plasmacytoma, SPG alone was ineffective. However, when combined with mitomycin C given with 1 to 5-days interval, the concurrent administration of SPG prolonged significantly the life-span of the tumor-bearing mice. These results indicated that the simultaneous administration of SPG and antitumor drugs may be a useful application method for immunochemotherapy of experimental tumors.
- Published
- 1982
37. [Clinical studies on the deficiency of vitamin K-dependent coagulation factors in adult patients].
- Author
-
Niiya K, Mitani M, Kitagawa T, Yamato K, Fujishita M, Okimoto N, Yoshimoto S, Kobayashi M, Kubonishi I, and Taguchi H
- Subjects
- Adult, Aged, Blood Coagulation Disorders blood, Blood Coagulation Tests, Blood Protein Electrophoresis, Female, Humans, Male, Prothrombin analysis, Blood Coagulation Disorders etiology, Vitamin K physiology, Vitamin K Deficiency etiology
- Published
- 1984
38. [Three operated cases of synchronous double cancers in the lung and stomach. A review of the Japanese literature].
- Author
-
Arimura T, Mitani M, Shimotakahara T, Maenohara S, Yamamoto S, Baba K, Tanaka T, Yunoki K, Takenoshita M, and Nishi M
- Subjects
- Adenocarcinoma surgery, Aged, Carcinoma, Squamous Cell surgery, Humans, Lung Neoplasms surgery, Male, Middle Aged, Prognosis, Stomach Neoplasms surgery, Adenocarcinoma pathology, Carcinoma, Squamous Cell pathology, Lung Neoplasms pathology, Neoplasms, Multiple Primary pathology, Stomach Neoplasms pathology
- Abstract
We encountered three patients with synchronous double cancers in the lung and stomach. Although the gastric cancers were resected curatively in all three patients, the lung cancers were resected palliatively because they were too advanced for curative resection. In the Japanese literature we found 25 operated cases of synchronous double cancers and 24 operated cases of metachronous double cancers in the lung and stomach. Early diagnosis and curative resection of both cancers improve the survival rate of these primary double cancers.
- Published
- 1984
39. [Problems in regulated respiration using Engström respirator. 2. Its clinical application].
- Author
-
Kaneko T, Tanaka T, Iwabuchi T, Mitani M, and Kobayashi T
- Subjects
- Adolescent, Adult, Alkalosis metabolism, Anesthesia, Child, Female, Humans, Male, Postoperative Care, Mitral Valve Insufficiency surgery, Tetralogy of Fallot surgery, Ventilators, Mechanical
- Published
- 1967
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