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16 results on '"Mukoyama, Masashi"'

1. 微生物の鉄捕捉分子と生体の防御機構

Author

Mori, Kiyoshi, Mukoyama, Masashi, and Nakao, Kazuwa

Subjects
siderophore, キレート, トランスフェリン, neutrophil gelatinase-associated lipocalin, Ngal
Abstract

鉄は細胞分裂に必須の元素であるので, 微生物は鉄濃度の低い環境から効率よく鉄を捕捉するためにシデロフォアと総称される鉄結合性有機化合物を合成, 分泌する. 一方, 最近の研究により, 晴乳類にはシデロフォア結合蛋白が存在し大腸菌や結核菌の鉄利用を阻害することで, 感染防御に役立つていることが解明された. シデロフォア結合蛋白は, 感染のほかにも細胞分化, 癌, 造血, アポトーシスなどの多彩な生命現象にも関わっている.

Published
2010

2. Clinical implication of a novel biomarker Ngal in CKD

Author

Mori, Kiyoshi, Mukoyama, Masashi, and Kuwabara, Takashige

Subjects
diagnosis, diabetic nephropathy, glomerular filtration, angiotensin receptor blocker, albuminuria
Abstract

We review diagnostic importance of neutrophil gelatinase-associated lipocalm(Ngal or lipocalin 2）in acute kidney injury and chronic kidney disease，and discuss the impact of novel biomarker analysis upon progress of nephrology

Published
2009

3. [Kidney and hypertension].

Author

Mukoyama M and Adachi M

Subjects
Angiotensins metabolism, Female, Humans, Kidney innervation, Kidney Diseases complications, Pregnancy, Receptors, Angiotensin immunology, Sodium Channels metabolism, Hypertension physiopathology, Hypertension therapy, Kidney physiopathology, Receptors, Angiotensin metabolism
Published
2016

4. [The Cutting-edge of Medicine; Endocrine disorders and renal disease].

Author

Mukoyama M

Subjects
Anemia drug therapy, Anemia etiology, Bone Density, Erythropoietin therapeutic use, Humans, Prognosis, Endocrine System Diseases complications, Endocrine System Diseases diagnosis, Endocrine System Diseases metabolism, Kidney Diseases complications, Kidney Diseases diagnosis, Kidney Diseases metabolism
Published
2015
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5. [Disease biomarkers for CKD].

Author

Mori K, Mukoyama M, Kasahara M, Yokoi H, and Nakao K

Subjects
Humans, Biomarkers urine, Kidney Failure, Chronic diagnosis
Abstract

As novel urinary biomarkers for kidney injury, neutrophil gelatinase-associated lipocalin (Ngal), kidney injury molecule-1 (KIM-1), liver-type fatty acid binding protein(L-FABP) et al. have emerged. Recent studies elucidated their usefulness in chronic kidney disease and acute kidney injury. Meanwhile, the understanding of clinical significance of albuminuria, a classical biomarker, has changed as well. In this review, the progress and current status of urinary biomarker research in the field of chronic kidney disease will be described and future problems to be solved will be discussed.

Published
2012

6. [Microalbuminuria].

Author

Mukoyama M, Mori K, and Nakao K

Subjects
Albuminuria urine, Humans, Metabolic Syndrome physiopathology, Albuminuria etiology, Metabolic Syndrome complications
Published
2011

7. [Evaluation of tubulointerstitial injury by new biomarkers].

Author

Mori K, Mukoyama M, Kasahara M, and Nakao K

Subjects
Animals, Biomarkers urine, Hepatitis A Virus Cellular Receptor 1, Humans, Lipocalin-2, Nephritis, Interstitial urine, Receptors, Virus, Acute-Phase Proteins urine, Fatty Acid-Binding Proteins urine, Lipocalins urine, Membrane Glycoproteins urine, Nephritis, Interstitial diagnosis, Proto-Oncogene Proteins urine
Published
2011

8. [Early biomarker for AKI].

Author

Mori K, Mukoyama M, and Nakao K

Subjects
Biomarkers blood, Biomarkers urine, Hepatitis A Virus Cellular Receptor 1, Humans, Lipocalin-2, Receptors, Virus, Acute Kidney Injury diagnosis, Acute-Phase Proteins urine, Early Diagnosis, Fatty Acid-Binding Proteins urine, Lipocalins blood, Lipocalins urine, Membrane Glycoproteins urine, Proto-Oncogene Proteins blood, Proto-Oncogene Proteins urine
Published
2010

9. [Novel biological involvements of siderophore-binding proteins in hematopoiesis, cell differentiation, tissue injury, carcinogenesis and infections].

Author

Mori K, Mukoyama M, and Nakao K

Subjects
Animals, Apoptosis genetics, Humans, Kidney pathology, Lipocalin-2, Neutrophils, Siderophores metabolism, Acute-Phase Proteins physiology, Cell Differentiation genetics, Hematopoiesis genetics, Infections genetics, Kidney cytology, Lipocalins physiology, Neoplasms genetics, Proto-Oncogene Proteins physiology, Siderophores physiology
Published
2009

10. [Clinical implication of a novel biomarker Ngal in CKD].

Author

Mori K, Mukoyama M, Kuwabara T, Kasahara M, Yokoi H, and Nakao K

Subjects
Animals, Humans, Lipocalin-2, Acute Kidney Injury diagnosis, Acute-Phase Proteins urine, Biomarkers urine, Kidney Failure, Chronic diagnosis, Lipocalins urine, Proto-Oncogene Proteins urine
Abstract

We review diagnostic importance of neutrophil gelatinase-associated lipocalin (Ngal or lipocalin 2) in acute kidney injury and chronic kidney disease, and discuss the impact of novel biomarker analysis upon progress of nephrology.

Published
2009

12. [Syndrome of inappropriate secretion of antidiuretic hormone].

Author

Mukoyama M and Nakao K

Subjects
Central Nervous System Diseases complications, Chlorpropamide adverse effects, Diagnosis, Differential, Furosemide administration & dosage, Humans, Neoplasms complications, Phenothiazines adverse effects, Saline Solution, Hypertonic administration & dosage, Water Deprivation, Inappropriate ADH Syndrome diagnosis, Inappropriate ADH Syndrome etiology, Inappropriate ADH Syndrome therapy
Published
2006

13. [Selective hypoaldosteronism].

Author

Mukoyama M and Nakao K

Subjects
Cytochrome P-450 CYP11B2 deficiency, Diabetes Complications, Diagnosis, Differential, Humans, Hyperkalemia etiology, Mitotane adverse effects, Mutation, Receptors, Mineralocorticoid genetics, Renin metabolism, Renin-Angiotensin System genetics, Renin-Angiotensin System physiology, Hypoaldosteronism classification, Hypoaldosteronism diagnosis, Hypoaldosteronism etiology, Hypoaldosteronism therapy
Published
2006

14. [Molecular biology in regulation of kidney functions: Natriuretic peptide system].

Author

Mukoyama M, Nakao K, and Kasahara M

Subjects
Animals, Diuresis, Guanylate Cyclase physiology, Humans, Kidney Diseases etiology, Mice, Mice, Transgenic, Natriuretic Peptides biosynthesis, Natriuretic Peptides genetics, Natriuretic Peptides metabolism, Receptors, Atrial Natriuretic Factor physiology, Kidney physiology, Natriuretic Peptides physiology
Published
2006

15. [Renal actions and renoprotective role of adrenomedullin].

Author

Mukoyama M, Nagae T, Yokoi H, and Nakao K

Subjects
Adrenomedullin, Calcitonin Receptor-Like Protein, Cell Division, Cyclic AMP metabolism, Diuresis, Fibrosis etiology, Fibrosis therapy, Genetic Therapy, Glomerular Mesangium cytology, Humans, Hypertension, Renal prevention & control, Intracellular Signaling Peptides and Proteins, Kidney pathology, Kidney Diseases etiology, Kidney Diseases prevention & control, Kidney Diseases therapy, Membrane Proteins physiology, Natriuresis, Nitric Oxide metabolism, Peptides genetics, Peptides therapeutic use, Receptor Activity-Modifying Proteins, Receptors, Calcitonin physiology, Renal Artery, Vasodilation, Peptides physiology
Published
2004

16. [Diuretic and renoprotective effects of natriuretic peptides].

Author

Mukoyama M, Suganami T, and Nakao K

Subjects
Animals, Cyclic GMP-Dependent Protein Kinases physiology, Disease Models, Animal, Glomerular Filtration Rate drug effects, Guanylate Cyclase physiology, Humans, Kidney Diseases etiology, Kidney Diseases prevention & control, Kidney Tubules, Proximal metabolism, Natriuresis drug effects, Natriuretic Peptides pharmacology, Natriuretic Peptides therapeutic use, Receptors, Atrial Natriuretic Factor physiology, Receptors, Enterotoxin, Receptors, Guanylate Cyclase-Coupled, Receptors, Peptide physiology, Diuresis drug effects, Kidney Diseases drug therapy, Natriuretic Peptides physiology
Published
2004

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