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Your search keyword '"Nucleic Acid Synthesis Inhibitors adverse effects"' showing total 1 results
Start Over Descriptor "Nucleic Acid Synthesis Inhibitors adverse effects" Language japanese
1 results on '"Nucleic Acid Synthesis Inhibitors adverse effects"'

1. [Complication of topoisomerase II inhibitor-related acute promyelocytic leukemia with t(1;10) (q21;q26) in a patient with Sézary syndrome].

Author

Miyoshi N and Noda M

Subjects
Aged, Humans, Male, Sezary Syndrome drug therapy, Skin Neoplasms drug therapy, Antineoplastic Agents, Phytogenic adverse effects, Etoposide adverse effects, Leukemia, Promyelocytic, Acute chemically induced, Nucleic Acid Synthesis Inhibitors adverse effects, Sezary Syndrome complications, Skin Neoplasms complications
Abstract

A 74-year-old man was diagnosed as having Sézary syndrome in 1999. Treatment with combination chemotherapy could not completely control both the erythroderma and Sézary cells. However, treatment with oral administration of etoposide was able to maintain the patient in a good condition for about 4 years. In June 2004, he developed topoisomerase II inhibitor-related acute promyelocytic leukemia. Chromosomal analysis demonstrated abnormalities of t(1;10) (q21;q26) and t(15;17) (q22;q12) in 17 of 20 cells. Despite treatment with ATRA and combination chemotherapy, the patient died of brain hemorrhage.

Published
2006

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