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Your search keyword '"Serine Proteinase Inhibitors metabolism"' showing total 5 results
Start Over Descriptor "Serine Proteinase Inhibitors metabolism" Language japanese
5 results on '"Serine Proteinase Inhibitors metabolism"'

1. [Thyroxine-binding globulin gene and variants].

Author

Seo H

Subjects
Chromosomes, Human, X genetics, Humans, Pancreatic Elastase physiology, Serine Proteinase Inhibitors metabolism, Thyroxine-Binding Proteins deficiency, Thyroxine-Binding Proteins metabolism, Mutation, Thyroxine-Binding Proteins genetics
Published
2006

2. [New AIDS-virus receptor and AIDS-virus infection mechanism].

Author

Katsunuma N

Subjects
Acquired Immunodeficiency Syndrome metabolism, Alpha-Globulins, Cell Degranulation, HIV-1 metabolism, Humans, Immunoglobulin E metabolism, Mast Cells metabolism, Mast Cells physiology, Peptide Hydrolases metabolism, Serine Proteinase Inhibitors metabolism, Acquired Immunodeficiency Syndrome immunology, HIV-1 physiology, Proteins, Receptors, HIV metabolism
Published
1990

5. [A study of antielastase activity in the development of pulmonary emphysema in a family with alpha 1-antitrypsin deficiency].

Author

Kishi F and Kakinoki A

Subjects
Adult, Bronchoalveolar Lavage Fluid enzymology, Female, Humans, Male, Middle Aged, Phenotype, Pulmonary Emphysema genetics, Pancreatic Elastase antagonists & inhibitors, Pulmonary Emphysema enzymology, Serine Proteinase Inhibitors metabolism, Serpins, alpha 1-Antitrypsin Deficiency
Abstract

The five siblings of a family with alpha 1-antitrypsin deficiency including three of Pi- and two of PiM- phenotypes, were studied for the development of pulmonary emphysema during nine years. The changes of pulmonary function showed significant decrease in FEV1.0 and V50, and increase in RV/TLC. Clinical diagnoses for each patient were assessed by pulmonary function, inhalation and perfusion lung scintigram. Two case of Pi- phenotypes were diagnosed definite pulmonary emphysema 9 years previously, in one case of Pi- emphysema was suspected and two PiM- cases were also suspected of emphysema. alpha 1-antitrypsin and elastase inhibitory capacity (EIC) were investigated in serum and bronchoalveolar lavage fluids (BALF) from four patients with alpha 1-antitrypsin deficiency, healthy non-smokers and smokers. alpha 1-Antitrypsin and EIC in BALF in patients with alpha 1-antitrypsin deficiency were markedly decreased. There were no differences between non-smokers and smokers in alpha 1-antitrypsin and EIC, but EIC in BALF showed a significant correlation with DLCO or %DLCO. These findings suggest that a deficiency of alpha 1-antitrypsin results in insufficient antielastase protection in the lower respiratory tract, and EIC in BALF may be useful for detecting early changes of emphysema.

Published
1989

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