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Background: Stickler syndrome is an autosomal dominant disease characterized by various disorders of the eyes and the connective tissues throughout the body. It can arise from a mutation in the collagen associated gene. We present a case of Stickler syndrome with rhegmatogenous retinal detachment., Case: A 10-years-old boy was referred to us with rhegmatogenous retinal detachment of the right eye. His family history included eye disease and a cleft palate. He had high myopia, vitreous liquefaction and lattice degeneration in the both eye. He also had a cleft palate and a broad nasal bridge. His condition was diagnosed as Stickler syndrome. We performed vitrectomy, scleral buckling and encircling, and silicone oil injection in the right eye. We also did a reattachment of the retina in the right eye., Conclusions: Pediatric retinal detachment may indicate the presence of Stickler syndrome and a complete examination of the eye as well as a full family history must be obtained in such cases.

Using adult albino rabbits, the clinical course of lens opacity and morphological changes of lens epithelial cells were observed from 2 weeks to 3 months after intravitreal silicone oil injection. Simple vitrectomy was performed in both rabbit eyes. One eye with silicone oil injection served as an experimental eye, while another control eye did not receive any injection. Seven examined eyes showed early posterior subcapsular lens opacity from one month after silicone oil injection by slit-lamp microscopy. Small intracellular vacuoles near to the interdigitation of the lens epithelial cells were observed in the 7 eyes from 2 weeks after the procedure by transmission electron microscopy. These changes were not observed in 7 control eyes. As a result, it is surmised that cataract formation after intravitreal silicone oil injection may be associated with morphological changes of the lens epithelial cells.

We examined diurnal variations of intraocular pressure (IOP) before and after scleral encircling, vitrectomy and silicone oil (S.O) tamponade in 7 patients (7 eyes) with proliferative diabetic retinopathy (PDR), and 8 patients (8 eyes) with proliferative vitreoretinopathy (PVR). They were all successfully operated and the IOP was lower than 24 mm Hg without medication. The contralateral, non-operated eye was used as the control. IOP was measured every 4 hours with Goldmann applanation tonometer or a pneumotonometer (Alcon) by the single examinee (S.H.). The amplitudes of the diurnal variation of the IOP with S.O. tamponade were smaller than those of the control eyes (p less than 0.05). Phakic eyes with silicon oil tamponade showed smaller amplitudes of IOP diurnal variation than those in aphakic eyes (p less than 0.05). The physiological significance is not clear yet, but these results suggest that the S.O. tamponade have some effect on the dynamics of the intraocular fluid in operated eyes (p less than 0.05).