299 results on '"Tamura, H."'
Search Results
2. Interaction between a Pair of Circular Cylinders in a Varied Free-Stream Direction
- Author
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Arie, M, Kiya, M, Tamura, H, and Mori, T
- Published
- 1978
3. RADIATION MONITORING IN THE ELECTRICAL COMMUNICATION LABORATORY.
- Author
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Tamura, H
- Published
- 1966
- Full Text
- View/download PDF
4. THE REDUCTION OF MONAZITE SAND WITH CARBON AT HIGH TEMPERATURE
- Author
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Tamura, H
- Published
- 1964
5. Changes in frequency of chromosome aberrations of human peripheral lymphocytes during the course of fractionated radiotherapy in cervical cancer, emphasis on the lymphocyte kinetics
- Author
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Tamura, H
- Published
- 1973
6. [Experience with Surgical Stabilization for Traumatic Rib Fractures and Sternal Fractures].
- Author
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Wada H, Yoshida S, Tamura H, Kamata T, Onozato Y, Karita R, and Yoshino I
- Subjects
- Humans, Fractures, Bone surgery, Rib Fractures surgery, Sternum surgery, Sternum injuries
- Abstract
The treatment of traumatic rib fractures and sternal fractures have focused on pain and respiratory management, and conservative treatment has been recommended. Recently, however, a number of case series from abroad have been reported and demonstrated the usefulness of surgical stabilization of rib fractures (SSRF) and sternal fractures (SSSF). We have experienced seven cases of SSRF and two cases of SSSF at International University Health and Welfare Narita Hospital and Atami Hospital. Based on our experienced cases, we have outlined the preoperative evaluation, indication for surgery, timing of surgery, surgical techniques, and postoperative course. Of these nine cases, the clinical course of two cases of SSRF and one case of SSSF were detailly presented. The surgical indications and techniques for traumatic rib fractures and sternal fractures vary from institution to institution, and there is no single optimal treatment. We hope that the accumulation of cases, and discussions will help to build a higher quality evidence for surgical treatment of thoracic trauma in Japan.
- Published
- 2024
7. [A Case of Fibromatosis-Like Tumor Which Was Difficult to Differentiate from Local Recurrence of Ascending Colon Cancer].
- Author
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Suzuki Y, Ikenaga M, Sato Y, Odagiri K, Yanagimoto Y, Yamashita M, Takeyama H, Kobayashi A, Shimizu J, Kawase T, Akagi K, Iwazawa T, Tamura H, Adachi S, and Imamura H
- Subjects
- Female, Humans, Colon, Ascending surgery, Anastomosis, Surgical, Combined Modality Therapy, Colonic Neoplasms surgery, Fibroma diagnostic imaging, Fibroma surgery
- Abstract
A 60s female, who had undergone single-incision laparoscopic ileocecal resection for ascending colon cancer with pathological diagnosis of T3N1bM0, Stage Ⅲb, followed by adjuvant therapy with 8 courses CAPOX 2 years ago, had enhanced- computed tomography(CT)for follow-up and a 15-mm nodule near anastomotic site was found. 18F-fluorodeoxyglucose (FDG)-positron emission tomography(PET)CT revealed abnormal accumulation of 18F-FDG only to the lesion and diagnosis of"anastomotic recurrence"was made. We planned and safely performed resection of the anastomotic site and the nodule. The pathological diagnosis was fibromatosis-like tumor without evidence of recurrence, and margin was negative. Postoperative course was smooth and she was discharged on postoperative day 9. When we diagnose local recurrence, we need to keep it in mind that fibromatosis is one of the differential diagnoses, although its incidence rate is low.
- Published
- 2024
8. [A Case of Diffuse Large B-Cell Lymphoma Which Was Diagnosed during the Best Supportive Care of Recurrent Ascending Colon Cancer].
- Author
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Suzuki Y, Ikenaga M, Sato Y, Odagiri K, Yanagimoto Y, Yamashita M, Takeyama H, Kobayashi A, Shimizu J, Kawase T, Akagi K, Iwazawa T, Tamura H, Adachi S, and Imamura H
- Subjects
- Male, Humans, Colon, Ascending surgery, Neoplasm Recurrence, Local, Ileal Neoplasms, Colonic Neoplasms drug therapy, Colonic Neoplasms surgery, Lymphoma, Large B-Cell, Diffuse drug therapy, Lymphoma, Large B-Cell, Diffuse surgery
- Abstract
A 70s male, who had undergone single-incision laparoscopic ileocecal resection for ascending colon cancer with pathological diagnosis of T3N3M0, Stage Ⅲc(without adjuvant chemotherapy), had enhanced-computed tomography(CT)for 3-month follow-up and a hepatic low-density area, an newly emergent nodule behind inferior vena cava and distal ileal tumor were found. Three months later, enhanced CT showed that the distal ileal tumor got exponentially larger and the diagnosis of"malignant lymphoma"was suspected. The patient became sepsis, so we planned and safely performed partial resection of the tumor. The pathological diagnosis was diffuse large B-cell lymphoma. Postoperative course was smooth except for the Clostridium difficile colitis and he was discharged on postoperative day 19. Although the regrowth of the remnant tumor was observed soon after surgery, partial response was confirmed after introduction of systemic chemotherapy. When we cope with malignant lymphoma of small intestine, we need to keep it in mind that surgery is an option for the prevention of perforation and bacterial translocation.
- Published
- 2024
9. [A case of invasive liver abscess syndrome caused by Klebsiella pneumoniae causing endophthalmitis-induced blindness].
- Author
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Tamura H, Ozono Y, Uchiyama N, Hatada H, Nakamura K, Iwakiri H, Hasuike S, Nagata K, and Kawakami H
- Subjects
- Female, Humans, Aged, 80 and over, Klebsiella pneumoniae, Blindness, Endophthalmitis drug therapy, Endophthalmitis etiology, Liver Abscess complications, Liver Abscess diagnostic imaging
- Abstract
An 82-year-old female patient was admitted to our hospital for visual acuity loss in both eyes. The patient was diagnosed with invasive liver abscess syndrome and bilateral endophthalmitis due to Klebsiella pneumoniae 4 days after the onset of ocular symptoms. The liver abscess improved by broad-spectrum antibiotics and intravitreal injection, but bilateral blindness occurred. Most literature reported fever as the first symptom of invasive abscess syndrome, but this case had no fever at the onset of ocular symptoms. Delayed invasive liver abscess syndrome diagnosis might cause poor visual acuity prognosis.
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- 2023
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10. [Promotion of Diversity in the Academic Field of Urology : Analysis of 10,000 Articles Published in Acta Urologica Japonica during a 65-Year Period].
- Author
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Kobayashi T, Tamura H, Hiragi S, Nishida S, Miyagawa M, Kuroda T, and Ogawa O
- Subjects
- Authorship, Bibliometrics, Female, Gender Equity, Humans, Time Factors, Urology
- Abstract
Gender equality is one of the most important issues in the promotion of diversity. The participation status of female urologists in academic activities has not been clarified. In the present study, we analyzed a total of 10,288 articles published by 58,914 authors in Acta Urologica Japonica since the first issue in 1955 to the present. The author's gender was determined by an application program interface for gender estimation in combination with independent manual confirmation by two researchers. The increasing rate (⊿person/⊿year) of female authors was as low as 0.067 in 1955-79, but increased to 0.400 in 1980-2000 and 0.814 in 2001-20. Over the time periods, the annual total numbers of female authors (person/year) showed an increasing trend from 3.2 in 1955-79 to 16.3 in 1980-2000 and 26.0 in 2001-20. The numbers of female author individuals, the ratio of female authors to all authors and the ratio of publications by female first author to all publications also showed similar trends. These results suggest that gender equality is becoming more prevalent in the academic field of urology. The methods and data of this study are considered to be useful for the promotion of gender equality in the academic field of urology for the future.
- Published
- 2021
- Full Text
- View/download PDF
11. [Molecular Basis of Preventive Effects of Habitual Coffee Intake against Chronic Diseases].
- Author
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Tamura H
- Subjects
- Adipogenesis, Alzheimer Disease metabolism, Amyloid Precursor Protein Secretases metabolism, Amyloid beta-Peptides metabolism, Animals, Aspartic Acid Endopeptidases metabolism, Catechols, Cells, Cultured, Disease Models, Animal, Food Handling, Hot Temperature, Humans, Insulin Receptor Substrate Proteins metabolism, Mice, NF-E2-Related Factor 2 metabolism, NF-kappa B metabolism, PPAR gamma metabolism, Proteasome Endopeptidase Complex metabolism, RAW 264.7 Cells, Alzheimer Disease prevention & control, Cataract prevention & control, Chronic Disease prevention & control, Coffee chemistry, Drinking physiology
- Abstract
Epidemiological studies have shown that coffee consumption may be associated with a lower risk of developing several chronic disorders. To elucidate the molecular mechanism of the effects of coffee, we analyzed molecular response upon exposure to coffee extract using cellular and animal models of these diseases. As obesity is recognized as a major risk factor for these chronic diseases, we investigated the effect of coffee on adipogenesis using mouse preadipocyte 3T3-L1 cells. We found that coffee induced proteasomal degradation of IRS-1, leading to reduction of PPARγ expression, a master transcription factor for adipogenesis. Reduction in weight as well as in IRS-1 expression was detected in the fat tissues of the high fat-diet-fed mice when reared with 60% coffee for 7 weeks. As for Alzheimer's disease, we analyzed the effect of coffee on amyloid β (Aβ) production in human neuronal SH-SY5Y cells. We found a 20% reduction in Aβ production when treated with 2.5% coffee for 2 d. This reduction was due to proteasomal degradation of BACE1 (β-secretase), which was activated by protein kinase A. In addition, coffee ameliorates LPS-induced inflammatory responses in RAW264.7 macrophages by reducing NFκB activity and Nrf2 activation. Roasted coffee prevents selenite-induced cataractogenesis by ameliorating antioxidant loss. Pyrocatechol, a component of roasted coffee, also reduced Aβ production and exhibits anti-inflammatory effects by a similar mechanism as coffee. Our results suggest that roasting coffee beans to generate pyrocatechol is necessary for the preventive effects of coffee intake on the chronic diseases.
- Published
- 2020
- Full Text
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12. [SLAM family proteins as therapeutic targets in multiple myeloma].
- Author
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Tamura H, Ishibashi M, Takahashi H, and Inokuchi K
- Subjects
- Antibodies, Monoclonal, Humans, Immunotherapy, Signaling Lymphocytic Activation Molecule Family Member 1, Multiple Myeloma
- Abstract
Reports have described the excellent efficacies of new immunotherapeutic strategies, such as monoclonal antibody (mAb) therapies, in multiple myeloma (MM) patients. Signaling lymphocytic activation molecule family (SLAMF) molecules are expressed strongly on normal lymphocytes and plasma cells from MM patients. The anti-SLAMF7 mAb elotuzumab (ELO) has been approved for the treatment of relapsed/refractory MM (RRMM). In MM patients, a high serum soluble SLAMF7 (sSLAMF7) concentration is associated with aggressive clinical characteristics. This suggests a proliferative function of the SLAMF7-sSLAMF7 interaction that could be inhibited by ELO. SLAMF3 is also expressed strongly and constitutively on myeloma cells. We observed the aggressive characteristics of SLAMF3
+ MM in vitro and in vivo. SLAMF3 interacts directly with the adaptor proteins SHP2 and GRB2. A gene expression analysis revealed that SLAMF3 transmits positive signals to MM cells via the MAPK/ERK signaling pathway and that sSLAMF3 levels are increased markedly in advanced MM. Thus, SLAMF3 may be a novel immunotherapeutic target in MM. SLAMF2 and SLAMF6 are also expressed strongly on MM cells, and the safety of antibody-drug conjugates that target these molecules in patients with RRMM is currently under study. Our and others' reports demonstrate the value of SLAMF molecules as promising new targets for antimyeloma immunotherapies.- Published
- 2020
- Full Text
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13. [Long-Term Survival after Surgical Treatment of Neuroendocrine Carcinoma of the Ampulla of Vater-A Case Report].
- Author
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Yoshioka R, Tomimaru Y, Noguchi K, Nagase H, Ogino T, Hirota M, Oshima K, Tanida T, Noura S, Imamura H, Iwazawa T, Akagi K, Tamura H, Adachi S, and Dono K
- Subjects
- Humans, Male, Neoplasm Recurrence, Local, Pancreaticoduodenectomy, Time Factors, Ampulla of Vater surgery, Carcinoma, Neuroendocrine surgery, Common Bile Duct Neoplasms surgery
- Abstract
A 60s man underwent upper gastrointestinal endoscopy at a regular medical check-up without symptoms, which showed an ulcerative region in the duodenal ampulla, measuring 3 cm in diameter. He was diagnosed with poorly differentiated adenocarcinoma on biopsy and referred to our hospital. Abdominal contrast-enhanced CT scan revealed an enhanced-ulcerative tumor, measuring 3 cm, at the duodenal ampulla. After the preoperative diagnosis of adenocarcinoma of the duodenal ampulla, subtotal stomach-preserving pancreatoduodenectomy with regional lymph node dissection was performed. The final diagnosis was neuroendocrine carcinoma(NEC)of the duodenal ampulla. He has been alive for 9 years with no recurrences. NEC of the duodenal ampulla is rare, and its prognosis is poor. We report a case of long-term survival after resection of NEC of the duodenal ampulla.
- Published
- 2019
14. [Postoperative Adjuvant Chemotherapy for Descending Colon Cancer Treated with Imatinib for Chronic Myeloid Leukemia].
- Author
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Tatsuta K, Harada T, Miyazaki S, Ogiku M, Hayashi T, Tamura H, Kanai T, Ikematsu Y, Naito K, and Nishiwaki Y
- Subjects
- Aged, Antineoplastic Agents, Chemotherapy, Adjuvant, Colon, Descending, Humans, Imatinib Mesylate, Male, Treatment Outcome, Colonic Neoplasms drug therapy, Colonic Neoplasms surgery, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive surgery
- Abstract
A66 -year-old man was diagnosed with chronic myeloid leukemia(CML). Imatinib treatment had been initiated, and a major molecular response(MMR)was achieved. The patient had anemia and was diagnosed with descending colon cancer. The patient was surgically treated, and then received postoperative adjuvant chemotherapy with UFT/LV. However, imatinib was not administered during that period. The patient could undergo postoperative adjuvant chemotherapy for 6 months without acute exacerbation of the CML.
- Published
- 2019
15. [A Rare Case of Adenosquamous Carcinoma in the Liver with Hepatolithiasis].
- Author
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Harino T, Tomimaru Y, Noguchi K, Nagase H, Ogino T, Hirota M, Oshima K, Tanida T, Noura S, Imamura H, Akagi K, Iwazawa T, Tamura H, Adachi S, and Dono K
- Subjects
- Aged, Bile Ducts, Intrahepatic, Humans, Male, Bile Duct Neoplasms diagnosis, Bile Duct Neoplasms surgery, Carcinoma, Adenosquamous diagnosis, Carcinoma, Adenosquamous surgery, Cholangiocarcinoma diagnosis, Cholangiocarcinoma surgery
- Abstract
This report describes a case of primary adenosquamous carcinoma of the liver with hepatolithiasis. A 70's man was followed up at a clinic for hepatolithiasis, gallbladder stone, and dilatation of the intrahepatic duct. He visited our hospital for computed tomography(CT)examination. CT showed a 30mm diameter low-density mass in the S2 liver and dilatation of the intrahe- patic duct filled with hepatolithiasis. Blood examination showed elevated levels of tumor markers(CEA 8.0 ng/mL, CA19-9 19,196 U/mL). We diagnosed the tumor as cholangiocellular carcinoma(cT2N1M0, cStage ⅣA)with hepatolithiasis and performed left hepatectomy and lymphadenectomy. In the specimen, a 39×22mm diameter solid tumor was detected and the intrahepatic duct was filled with haptolithiasis. Pathologically, a mixture of adenocarcinoma and squamous cell carcinoma was observed adjacent to the bile duct. Accordingly, a diagnosis of adenosquamous carcinoma was made(pT3N0M0, pStage Ⅲ). Multiple liver metastases were detected 8 months after the operation, and chemotherapy was started. He remains alive 11 months after the operation. We experienced a rare case of adenosquamous carcinoma in the liver with hepatolithiasis.
- Published
- 2019
16. [A Resected Case of Reactive Lymphoid Hyperplasia of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma].
- Author
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Yoshioka R, Tomimaru Y, Noguchi K, Nagase H, Ogino T, Hirota M, Oshima K, Tanida T, Noura S, Imamura H, Iwazawa T, Akagi K, Tamura H, Adachi S, and Dono K
- Subjects
- Female, Humans, Neoplasm Recurrence, Local, Carcinoma, Hepatocellular diagnosis, Liver Neoplasms diagnosis, Pseudolymphoma diagnosis
- Abstract
A60s woman was followed-up regularly for primary biliary cholangitis and a solitary enlarging hepatic mass in the S6 segment of her liver was discovered by ultrasonography. We diagnosed the mass as hepatocellular carcinoma by contrast ultrasonography, contrast computed tomography, and ethoxbenzyl magnetic resonance imaging and laparoscopic partial hepatectomy of S6 segment was performed. The resected specimen was histopathologicaly diagnosed as liver-reactive lymphoid hyperplasia(RLH). The patient is alive without recurrence 17 months after the surgery. Although liver RLH is a rare disease, it should be considered in the differential diagnosis of small liver tumors.
- Published
- 2019
17. [Amebic liver abscesses developing during R-CHOP chemotherapy in a patient with mantle cell lymphoma].
- Author
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Moriya K, Tamura H, Asayama T, Kuribayashi Y, Okamoto M, and Inokuchi K
- Subjects
- Antibodies, Monoclonal, Murine-Derived adverse effects, Cyclophosphamide adverse effects, Doxorubicin adverse effects, Humans, Male, Middle Aged, Prednisone adverse effects, Rituximab, Vincristine adverse effects, Antineoplastic Combined Chemotherapy Protocols adverse effects, Entamoeba histolytica, Liver Abscess, Amebic chemically induced, Lymphoma, Mantle-Cell drug therapy
- Abstract
A 51-year-old man was diagnosed with stage IV mantle cell lymphoma based on terminal ileum biopsy and treated with the R-CHOP regimen. Abdominal CT to assess continuous fever after three courses of R-CHOP revealed three low-density areas in the liver. PCR of the fluid obtained by percutaneous drainage revealed Entamoeba histolytica positivity, although the cultures were negative. Metronidazole treatment achieved cure. The patient was not a homosexual but had an 8-month stay in Lesotho 21 years ago, leading to the possibility that E. histolytica infection at the time continued as an asymptomatic colonization until the initiation of corticosteroid-containing chemotherapy.
- Published
- 2019
- Full Text
- View/download PDF
18. [A Case of Unresectable Advanced Gastric Neuroendocrine Cell Carcinoma Treated with Nivolumab].
- Author
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Yoshioka R, Nagase H, Noguchi K, Hamabe A, Hirota M, Oshima K, Tanida T, Ogino T, Tomimaru Y, Kawase T, Noura S, Imamura H, Iwasawa T, Akagi K, Ando H, Tamura H, Adachi S, and Dono K
- Subjects
- Aged, Bone Neoplasms secondary, Carcinoma, Neuroendocrine surgery, Combined Modality Therapy, Fatal Outcome, Humans, Male, Stomach Neoplasms pathology, Stomach Neoplasms surgery, Antineoplastic Agents, Immunological therapeutic use, Carcinoma, Neuroendocrine drug therapy, Nivolumab therapeutic use, Stomach Neoplasms drug therapy
- Abstract
A 69-year-old man was administered S-1/oxaliplatin/trastuzumab as induction chemotherapy for advanced gastric cancer (cT4b[liver, pancreas], N2M1(H1P0CYX), cStage IV). After 4 courses, because contrast-enhanced computed tomography showed remarkable reduction of the tumor, distal gastrectomy, partial hepatectomy, and radiofrequency ablation for the liver metastasis were performed. The patient was histopathologically diagnosed with gastric neuroendocrine carcinoma(NEC). S- 1/oxaliplatin/trastuzumab was continued after surgery; however, recurrence in the remnant liver was observed after 4 cours- es. For recurrence, cisplatin/irinotecan as first-line and paclitaxel/ramucirumab as second-line treatment were administered, but progression of liver metastasis and ascites due to peritoneal dissemination were observed. As third-line treatment, nivolumab was initiated. Ascites decreased after 3 courses, but after 2 more courses, progression of ascites, liver recurrence, and multiple metastasis in the lumbar vertebra were observed.
- Published
- 2018
19. [Immunopathogenesis and appropriate use of monoclonal antibody agents in multiple myeloma].
- Author
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Tamura H
- Subjects
- Antibodies, Monoclonal, Humanized, Humans, Immunotherapy, Japan, Antibodies, Monoclonal therapeutic use, Antineoplastic Agents, Immunological therapeutic use, Multiple Myeloma therapy
- Abstract
Multiple myeloma (MM) involves the immune dysregulation not only of B cells but also of NK, T, and dendritic cells. Furthermore, the number of regulatory T and myeloid-derived immunosuppressive cells, which are associated with disease progression, also increases. Immunomodulatory drugs (IMiDs) such as lenalidomide and pomalidomide exhibit an antimyeloma effect and improve the immune status. Thus, IMiD-enhanced antibody-dependent cell cytotoxicity increases the cytotoxic activity of monoclonal antibody treatment. Among many antibodies, anti-SLAMF7 elotuzumab and anti-CD38 daratumumab have been approved in Japan, and their targeted antigens are responsible for functions that may influence clinical efficacy. Daratumumab exerts various mechanisms of antitumor activity and enhances T-cell immunity by inhibiting immunosuppressive cells. New monoclonal antibodies, including the anti-CD38 antibody isatuximab and anti-BCMA antibody-drug conjugate, are being developed and are expected to demonstrate clinical efficacy. To improve long-term prognosis and achieve cure for MM, immunotherapies such as IMiD-intensified antibody treatment, which resulted in better response rates and longer survival in refractory/relapsed MM, are essential.
- Published
- 2018
- Full Text
- View/download PDF
20. [Surgical Resection after Gemcitabine plus Cisplatin Chemotherapy for Intrahepatic Cholangiocarcinoma with Multiple Lymph Node Metastases - Report of a Case].
- Author
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Otani T, Sakata J, Kameyama H, Otani A, Hirose Y, Tamura H, Morimoto Y, Miura K, Yoshino K, Kido T, Kobayashi T, Endo K, and Wakai T
- Subjects
- Aged, 80 and over, Bile Duct Neoplasms surgery, Cholangiocarcinoma surgery, Cisplatin administration & dosage, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Hepatectomy, Humans, Lymphatic Metastasis, Male, Neoadjuvant Therapy, Gemcitabine, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bile Duct Neoplasms drug therapy, Cholangiocarcinoma drug therapy
- Abstract
An 82-year-old man with upper abdominal pain was referred to our hospital because of an elevated serum CEA level and dilatation of the intrahepatic bile ducts on ultrasonography.Computed tomography revealed a hypovascular mass measuring 5.0 cm in size in the lateral section, dilatation of the peripheral intrahepatic bile ducts, and swollen lymph nodes around the lesser curvature of the stomach, the common hepatic artery, and the paraaorta.He was diagnosed with unresectable intrahepatic cholangiocarcinoma, and he received chemotherapy with biweekly gemcitabine plus cisplatin.After 33 courses of the chemotherapy, computed tomography revealed that the tumor size decreased over 63%, and all swollen lymph nodes had almost resolved.He underwent a left hemihepatectomy 1 year 6 months after the start of the chemotherapy.He remains alive and well with no evidence of recurrence, 11 months after resection.
- Published
- 2016
21. [Two Episodes of Colostomy-Associated Intestinal Perforation during Chemotherapy for Metastatic Rectal Cancer].
- Author
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Tamura H, Otani A, Tsukui M, Toge K, Otani T, Hirose Y, Morimoto Y, Yoshino K, Kido T, Endo K, Kameyama H, Kobayashi T, and Wakai T
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Colostomy, Female, Humans, Intestinal Perforation surgery, Liver Neoplasms secondary, Multimodal Imaging, Rectal Neoplasms pathology, Rectal Neoplasms surgery, Antineoplastic Combined Chemotherapy Protocols adverse effects, Intestinal Perforation chemically induced, Liver Neoplasms drug therapy, Rectal Neoplasms drug therapy
- Abstract
A 77-year-old woman with rectal cancer and synchronous liver metastasis underwent a Hartmann operation with D3 lymph node dissection in June 2014. mFOLFOX6 plus bevacizumab(bev)was then administered to treat the liver metastasis.In February 2015, multiple liver metastases were detected and the regimen was changed to FOLFIRI plus bev.After 3 courses, peritonitis due to intestinal perforation around the descending colostomy occurred, and an emergency operation(partial resection of the descending colon and transverse colostomy)was performed.FOLFIRI was then administered from 2 months after the operation.After 3 courses of this regimen, a CT scan showed progression of the hepatic metastases.The regimen was therefore changed to mFOLFOX6.Five months later, another CT scan showed an intestinal perforation of the transverse colostomy at the abdominal wall, and an emergency cecostomy was performed.At this stage, chemotherapy was ceased.This case highlights the risk of intestinal perforation during chemotherapy, regardless of the use of bev.
- Published
- 2016
22. [A Case of Axillary Nodal Metastasis of Adenocarcinoma of an Unknown Primary Site Effectively Treated with Anti-HER2plus AC plus Paclitaxel Therapy].
- Author
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Shima S, Toriumi T, Nomura Y, Tamura H, and Hirano M
- Subjects
- Adenocarcinoma surgery, Aged, Axilla pathology, Biopsy, Needle, Chemotherapy, Adjuvant, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Female, Humans, Lymphatic Metastasis, Neoadjuvant Therapy, Neoplasms, Unknown Primary pathology, Neoplasms, Unknown Primary surgery, Paclitaxel administration & dosage, Trastuzumab administration & dosage, Adenocarcinoma drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Lymph Nodes pathology, Neoplasms, Unknown Primary drug therapy
- Abstract
A 68-year-old woman who presented with a left axillary mass was admitted. A computed tomography scan showed swelling ofthe left axillary and supraclavicular lymph nodes, but magnetic resonance imaging(MRI)and fluorodeoxyglucose positron emission tomography(FDG-PET)did not reveal these primary sites. Histological findings of the axillary mass revealed a HER2-positive adenocarcinoma. We diagnosed the patient with axillary nodal metastasis ofadenocarcinoma ofan unknown primary site and treated her with neoadjuvant chemotherapy including paclitaxel and trastuzumab followed by doxorubicin and cyclophosphamide. The lesions almost disappeared after 3 courses of chemotherapy and she showed a pathologically complete response(CR)after surgery. The patient has been recurrence-free since the operation owing to treatment with adjuvant trastuzumab.
- Published
- 2016
23. Functional role of cortical astrocytes in sleep/affective dysregulation under the chronic pain: analysis by artificial control of astrocytes using optogenetics.
- Author
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Hamada Y, Yamashita A, Tamura H, Narita M, Kuzumaki N, and Narita M
- Subjects
- Animals, Humans, Optogenetics methods, gamma-Aminobutyric Acid metabolism, Astrocytes physiology, Chronic Pain, Mood Disorders physiopathology, Sleep Wake Disorders physiopathology
- Published
- 2016
- Full Text
- View/download PDF
24. Recent advances and future challenges in cancer immunotherapy.
- Author
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Okuyama N, Tamada K, and Tamura H
- Subjects
- Combined Modality Therapy, Humans, Neoplasms immunology, Receptors, Antigen, T-Cell immunology, T-Lymphocytes immunology, Immunotherapy, Neoplasms therapy
- Abstract
Remarkable advances have been made in cancer immunotherapy. Recent treatment strategies, especially chimeric antigen receptor-T (CAR-T) cell therapy and immune checkpoint inhibitors, reportedly achieve higher objective responses and better survival rates than previous immunotherapies for patients with treatment-resistant malignancies, creating a paradigm shift in cancer treatment. Several clinical trials of cancer immunotherapy for patients with various malignancies are ongoing. However, those with certain malignancies, such as low-immunogenic cancers, cannot be successfully treated with T-cell immunotherapy, and subsets of immunotherapy-treated patients relapse, meaning that more effective immunotherapeutic strategies are needed for such patients. Furthermore, the safety, convenience, and cost of cancer immunotherapy need to be improved in the near future. Herein, we discuss recent advances and future challenges in cancer immunotherapy, i.e., the identification of neoantigens for the development of individualized immunotherapies, the development of new CAR-T cell therapies, including so-called armored CAR-T cells that can induce greater clinical effects and thereby achieve longer survival, the development of off-the-shelf treatment regimens using non-self cells or cell lines, and effective cancer immunotherapy combinations.
- Published
- 2016
- Full Text
- View/download PDF
25. Treatment strategy for transplant-ineligible patients with newly diagnosed multiple myeloma.
- Author
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Tamura H
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cell Transplantation, Humans, Multiple Myeloma diagnosis, Patient Selection, Practice Guidelines as Topic, Quality of Life, Treatment Outcome, Multiple Myeloma therapy
- Abstract
The current therapeutic strategy for multiple myeloma has improved dramatically due to the use of novel agents. In newly diagnosed transplant-ineligible myeloma patients, the standard therapy until the 1990s had long been melphalan and prednisolone (MP), but the recent recommendation is the proteasome inhibitor bortezomib plus MP (MPB), the immunomodulatory drug thalidomide plus MP (MPT), and the thalidomide derivative lenalidomide (LEN)-based regimens such as LEN plus low-dose dexamethasone (Ld) and LEN plus MP (MPL). The overall response rate in patients treated with Ld, MPL, or MPB was reported to be approximately 70%. Achieving complete remission (CR) is important in elderly as well as younger patients. Therefore, MPB administration appears to be the most appropriate initial therapy because the MPB regimen results in high CR rates. However, in elderly patients, especially in those 75 years of age and older and those who are frail or with comorbidities, it is important to balance efficacy and toxicity as well as to maintain quality of life. Furthermore, continuous treatment results in longer survival than a fixed-duration regimen in this population.
- Published
- 2016
- Full Text
- View/download PDF
26. A case of hypertrophic pachymenigitis of IgG4-related disease, which is happened for the duration of treat polymyalgia rheumatica.
- Author
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Sasaki K, Ohtani H, Fujii M, Yamada H, Otsuka S, Tamura H, and Nunomura M
- Subjects
- Female, Humans, Hypertrophy diagnosis, Hypertrophy pathology, Immunoglobulin G immunology, Meningitis pathology, Middle Aged, Polymyalgia Rheumatica pathology, Treatment Outcome, Hypertrophy drug therapy, Meningitis diagnosis, Meningitis drug therapy, Polymyalgia Rheumatica diagnosis, Polymyalgia Rheumatica drug therapy, Steroids therapeutic use
- Published
- 2015
- Full Text
- View/download PDF
27. [Three Cases of Stage Ⅳ Low Rectal Cancer with Lateral Pelvic Lymph Node Metastasis].
- Author
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Tamura H, Shimada Y, Yagi R, Tajima Y, Okamura T, Nakano M, Ishikawa T, Sakata J, Kobayashi T, Kameyama H, Kosugi S, Wakai T, Nogami H, Maruyama S, and Takii Y
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Humans, Liver Neoplasms drug therapy, Liver Neoplasms secondary, Liver Neoplasms surgery, Lung Neoplasms drug therapy, Lung Neoplasms secondary, Lung Neoplasms surgery, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Pelvis surgery, Rectal Neoplasms drug therapy, Rectal Neoplasms surgery, Recurrence, Tomography, X-Ray Computed, Pelvis pathology, Rectal Neoplasms pathology
- Abstract
Case 1: A 61-year-old man who had a diagnosis of low rectal cancer with lateral pelvic lymph node (LPLN) metastasis and multiple liver metastases underwent low anterior resection with LPLN dissection. The initial surgery was followed by chemotherapy, and then an extended right hepatectomy with partial resection of the liver was performed. Subsequently, a lung metastasis was detected, and the lung was partially resected. The patient was alive 9 years and 6 months after the initial operation. Case 2: A 53-year-old man had a diagnosis of low rectal cancer. After 5 courses of mFOLFOX6 plus bevacizumab, he underwent low anterior resection with LPLN dissection and resection of the peritoneal metastasis. The patient was alive 6 years and 3 months after the surgery without any signs of recurrence. Case 3: A 48-year-old man had a diagnosis of low rectal cancer and multiple liver metastases. He underwent low anterior resection with LPLN dissection and right hepatic lobectomy. He subsequently showed liver and lung metastases. The patient received systemic chemotherapy, and is alive with recurrent disease. We report 3 cases of Stage Ⅳ low rectal cancer with LPLN metastasis, and propose that LPLN dissection is important as a part of R0 resection for Stage Ⅳ low rectal cancer.
- Published
- 2015
28. [Pain and emotional dysregulation: Cellular memory due to pain].
- Author
-
Narita M, Watanabe M, Hamada Y, Tamura H, Ikegami D, Kuzumaki N, and Igarashi K
- Subjects
- Dopamine physiology, Emotions physiology, Epigenomics, Humans, Pain physiopathology
- Abstract
Genetic factors are involved in determinants for the risk of psychiatric disorders, and neurological and neurodegenerative diseases. Chronic pain stimuli and intense pain have effects at a cellular and/or gene expression level, and will eventually induce "cellular memory due to pain", which means that tissue damage, even if only transient, can elicit epigenetically abnormal transcription/translation and post-translational modification in related cells depending on the degree or kind of injury or associated conditions. Such cell memory/transformation due to pain can cause an abnormality in a fundamental intracellular response, such as a change in the three-dimensional structure of DNA, transcription, or translation. On the other hand, pain is a multidimensional experience with sensory-discriminative and motivational-affective components. Recent human brain imaging studies have examined differences in activity in the nucleus accumbens between controls and patients with chronic pain, and have revealed that the nucleus accumbens plays a role in predicting the value of a noxious stimulus and its offset, and in the consequent changes in the motivational state. In this review, we provide a very brief overview of a comprehensive understanding of chronic pain associated with emotional dysregulation due to transcriptional regulation, epigenetic modification and miRNA regulation.
- Published
- 2015
29. [Evaluation of the enhanced International Prognostic Index (NCCN-IPI) for cases with diffuse large B-cell lymphoma].
- Author
-
Yamada A, Tamura H, Asayama T, Moriya K, Okuyama N, Kondo-Onodera A, Hamada Y, Ishibashi M, Yokose N, Tanosaki S, and Inokuchi K
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Female, Follow-Up Studies, Humans, Lymphoma, Large B-Cell, Diffuse drug therapy, Male, Middle Aged, Prognosis, Retrospective Studies, Young Adult, Lymphoma, Large B-Cell, Diffuse pathology
- Abstract
The NCCN-International Prognostic Index (IPI) is reported to be more powerful than the former IPI for predicting survival in the rituximab era. To evaluate the NCCN-IPI in our institutions, we analyzed 188 patients with diffuse large B-cell lymphoma treated with rituximab plus CHOP or THP-COP chemotherapy. The 5-year overall survival rates of patients with low, low-intermediate, high-intermediate, and high risk were 90%, 76%, 64%, and 34%, respectively. Although there was no difference in overall survival between patients 61-75 and those >75 years of age, the NCCN-IPI is useful for classifying prognostically relevant subgroups of Japanese patients.
- Published
- 2015
- Full Text
- View/download PDF
30. [Visual Recognition of the Shitsukan, or Material Properties, of Objects].
- Author
-
Yamane Y and Tamura H
- Subjects
- Animals, Humans, Macaca, Temporal Lobe physiology, Visual Perception physiology
- Abstract
Natural objects, such as animals, flowers, and wood, as well as artificial objects, such as Japanese lacquerware, glass, and metal coins, have their own shape and surface appearances. Although object shapes play important roles in visual object recognition, the material properties or Shitsukan of objects are relevant for the recognition of visual objects. In this review, we introduce recent advances in the understanding of the neural basis of the cognition of Shitsukan. First, we introduce the results of single-neuron recording studies that examined neuronal activity in the inferior temporal cortex of macaque monkeys in response to the presentation of two-dimensional and three-dimensional shapes. Next, we introduce the studies of neuronal response property to the Shitsukan of objects, such as color, texture, glossiness, and the combinations of these features. Then, we discuss how the selective responses to Shitsukan are constructed by hierarchical processing in the ventral visual cortical pathway, which consists of V1, V2, and V4. Finally, we discuss the encoding of Shitsukan information in the inferior temporal cortex.
- Published
- 2015
- Full Text
- View/download PDF
31. [Single vs double stem cell transplantation for the treatment of multiple myeloma].
- Author
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Tamura H
- Subjects
- Humans, Randomized Controlled Trials as Topic, Remission Induction, Transplantation, Autologous, Multiple Myeloma therapy, Stem Cell Transplantation methods
- Abstract
High-dose therapy followed by autologous stem cell transplantation (ASCT) is the current optimal up-front treatment for younger, transplantation-eligible multiple myeloma patients, although the efficacy of double (tandem) ASCT remains unclear in previously untreated patients. According to published randomized trials and recent meta-analysis, double ASCT improved event-free survival and overall survival compared with single ASCT but increased transplant-related mortality. Double ASCT is now recommended for the treatment of patients who failed to achieve a very good response or better after the first transplantation. Further studies will be required to determine whether double ASCT is still needed in patients treated with highly effective novel agents.
- Published
- 2015
32. [A case of cardiopulmonary arrest due to hypersensitivity reaction to oxaliplatin for multiple liver and lung metastases of colon cancer].
- Author
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Tamura H, Kameyama H, Toge K, Usui K, Enomoto T, Watanabe N, Hayashi T, Shimada Y, and Wakai T
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemotherapy, Adjuvant, Colectomy, Humans, Male, Oxaliplatin, Colonic Neoplasms drug therapy, Colonic Neoplasms pathology, Drug Hypersensitivity physiopathology, Heart Arrest chemically induced, Liver Neoplasms drug therapy, Liver Neoplasms secondary, Lung physiopathology, Lung Neoplasms drug therapy, Lung Neoplasms secondary, Organoplatinum Compounds adverse effects
- Abstract
A 69-year-old man underwent right hemicolectomy and D3 lymphadenectomy for transverse colon cancer in 2009. Under the postoperative pathological diagnosis of Stage IIIb (pT3pN2cM0) cancer, he was given 8 courses of adjuvant chemotherapy with capecitabine. After the chemotherapy, in April 2013, we detected recurrence of the multiple liver and lung metastases; thus, we administered modified 5-fluorouracil, Leucovorin, oxaliplatin (mFOLFOX6) and bevacizumab. Six courses of oxaliplatin infusion were completed uneventfully. However, 3 min after starting the seventh infusion courses, the patient experienced cardiopulmonary arrest. We immediately performed cardiopulmonary resuscitation. The patient's anaphylaxis symptoms resolved after treatment with intravenous epinephrine. He was discharged 3 days after the event with no further complications. Clinicians should be aware that oxaliplatin-induced anaphylactic shock often occurs during the eighth infusion cycle and that this severe hypersensitivity reaction is difficult to predict and prevent.
- Published
- 2014
33. [Successful treatment with rituximab in a patient with splenic marginal zone B-cell lymphoma accompanied by cold agglutinin disease].
- Author
-
Yasuyama M, Kawauchi K, Otsuka K, Tamura H, and Fujibayashi M
- Subjects
- Aged, 80 and over, Humans, Lymphoma, B-Cell, Marginal Zone complications, Male, Anemia, Hemolytic, Autoimmune etiology, Antineoplastic Agents therapeutic use, Lymphoma, B-Cell, Marginal Zone drug therapy, Rituximab therapeutic use, Splenic Neoplasms drug therapy
- Abstract
An 81-year-old man was admitted to our hospital due to dyspnea in July 2008. A physical examination revealed marked splenomegaly, and the results of laboratory tests were as follows: hemoglobin (Hb)=7.0 g/dL, Ret=6.4%, WBC=24,100/μL (Ly: 20,003/μL), indirect bilirubin=3.6 mg/dL, LDH=232 IU/L. The cold agglutinin titer was 1 : 8,192, and a direct antiglobulin test was positive. A PET scan showed abnormal accumulation in the spleen and bone marrow. A bone marrow aspirate examination and biopsy demonstrated diffuse involvement of abnormal lymphocytes that were found to be positive for CD20 and negative for CD5, CD10, and cyclin D1. The immunoglobulin genes were clonally rearranged. Based on these findings, splenic marginal zone B-cell lymphoma (SMZL) associated with cold agglutinin disease (CAD) was diagnosed. Because the patient refused splenectomy, he was treated with four cycles of rituximab therapy (375 mg/kg, once a week). The Hb level and lymphocyte count subsequently normalized and the splenomegaly resolved. One year later, he relapsed and was again treated with rituximab therapy with complete remission. CAD accompanied by SMZL is very rare. Rituximab may be chosen as an alternative and effective therapeutic option in patients with SMZL-particularly those with autoimmune hemolytic anemia.
- Published
- 2014
- Full Text
- View/download PDF
34. [Slice profile measurement using a crossed thin-ramps method in three-dimensional magnetic resonance imaging].
- Author
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Yoshida R, Machida Y, Ogura T, Tamura H, Hikichi T, and Mori I
- Subjects
- Artifacts, Magnetic Resonance Imaging instrumentation, Image Enhancement methods, Imaging, Three-Dimensional methods, Magnetic Resonance Imaging methods, Phantoms, Imaging
- Abstract
Recent progress in variable-flip-angle fast spin-echo technology has further extended the utility of three-dimensional (3D) magnetic resonance imaging (MRI) for clinical application. The slice profile in 3D MRI is the point spread function that has a sync form in principle, whereas a slice profile in 2D imaging provides information on characteristics of selective radio frequency excitation. We investigated the optimal condition to measure 3D slice profiles using a crossed thin-ramps phantom. We found that the profile data should cover a large area in order to evaluate both the main lobe and side lobes in the slice profile, and that the appropriate slice thickness was 2 mm. We also found that artifacts in the direction perpendicular to the slice create an offset error in the measured slice profile when 3D imaging. In this paper, we describe the optimal condition and some remarks on the slice profile evaluation for 3D MRI.
- Published
- 2012
- Full Text
- View/download PDF
35. [A case of locally advanced sigmoid colon cancer invading the bladder and seminal vesicle effectively treated with preoperative mFOLFOX6].
- Author
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Hirayama K, Hayashi T, Nishiwaki Y, Kamishima M, Furuhashi S, Fukushima H, Nakata Y, Tamura H, Kanai T, Ikematsu Y, Mori H, and Ozawa T
- Subjects
- Aged, Biopsy, Combined Modality Therapy, Fluorouracil therapeutic use, Humans, Leucovorin therapeutic use, Male, Neoplasm Invasiveness, Organoplatinum Compounds therapeutic use, Sigmoid Neoplasms pathology, Sigmoid Neoplasms surgery, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Seminal Vesicles pathology, Sigmoid Neoplasms drug therapy, Urinary Bladder pathology
- Abstract
A 77-year-old male was admitted to our hospital complaining of dyschezia. Computed tomography (CT) and colonoscopy (CF) revealed a huge sigmoid colon cancer invading the bladder and seminal vesicle. Chemotherapy with mFOLFOX6 was initiated preoperatively, and the tumor shrunk markedly after seven courses of treatment. Pelvic exenteration with negative margins was carried out. The patient is still alive and disease-free 16 months after surgery. It was suggested that mFOLFOX6 may be useful for advanced colon cancer invading other organs when used as neoadjuvant chemotherapy.
- Published
- 2011
36. [Investigation of FOLFIRI/FOLFOX (+/-bevacizumab) therapy for patients with metastatic colorectal cancer in our hospital].
- Author
-
Hosoda K, Aoki M, Kido H, Natsu K, Tamura H, Kojima M, Amemiya T, and Kamoshida T
- Subjects
- Aged, Aged, 80 and over, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal immunology, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Bevacizumab, Camptothecin administration & dosage, Camptothecin analogs & derivatives, Camptothecin therapeutic use, Colorectal Neoplasms diagnostic imaging, Colorectal Neoplasms immunology, Female, Fluorouracil administration & dosage, Fluorouracil therapeutic use, Hospitals, General, Hospitals, Public, Humans, Leucovorin administration & dosage, Leucovorin therapeutic use, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Staging, Organoplatinum Compounds administration & dosage, Organoplatinum Compounds therapeutic use, Survival Rate, Tomography, X-Ray Computed, Treatment Outcome, Antibodies, Monoclonal therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Colorectal Neoplasms drug therapy, Colorectal Neoplasms pathology
- Abstract
Unlabelled: Bevacizumab has been demonstrated to prolong survival in patients with metastatic colorectal cancer when used in combination with chemotherapy. We investigated the efficacy of chemotherapy administered in our general hospital for patients with metastatic colorectal cancer after the introduction of FOLFOX/FOLFIRI (+/-bevacizumab) therapy., Subjects and Methods: The subjects in this study were 34 patients diagnosed with metastatic colorectal cancer, who received either FOLFIRI (+/- bevacizumab) or mFOLFOX6 (+/-bevacizumab) therapy in this hospital. The subjects were divided into a bevacizumab combination regimen group (those who received the regimen as first-line treatment), and a non-bevacizumab combination regimen group (those who did not receive the regimen as first-line treatment). Comparisons were made with regard to anticancer efficacy, progression-free survival time, and overall survival time., Results: Comparison between the bevacizumab combination regimen group and the non-bevacizumab combination regimen group, revealed no significant difference due to the small number of relevant patients. However, the former showed a slight advantage over the latter in terms of anti-cancer efficacy and progression-free survival time., Conclusion: Bevacizumab is expected to contribute to the prolongation of survival in patients in our general hospital.
- Published
- 2010
37. [Analysis of blood concentrations following oral administration of beclomethasone dipropionate for gut GVHD].
- Author
-
Ito T, Watanabe K, Nasu I, Ino K, Minowa M, Furusawa M, Okuno Y, Uchida Y, Miyazaki Y, Tamura H, Hasebe S, Takagi S, Yamamoto H, Matsuno N, Uchida N, Masuoka K, Wake A, Makino S, Taniguchi S, and Hayashi M
- Subjects
- Administration, Oral, Adult, Aged, Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents therapeutic use, Beclomethasone administration & dosage, Beclomethasone therapeutic use, Female, Graft vs Host Disease drug therapy, Graft vs Host Disease immunology, Humans, Intestinal Diseases drug therapy, Intestinal Diseases immunology, Male, Middle Aged, Anti-Inflammatory Agents blood, Beclomethasone blood, Graft vs Host Disease blood, Intestinal Absorption drug effects, Intestinal Diseases blood
- Abstract
In this study, we investigated the level of gut absorption following oral beclomethasone dipropionate (BDP) administration by measuring the blood concentration of its metabolites measured by LC-MS/MS using the HPLC method. Five patients who were administered BDP orally for gut GVHD were included. The blood concentrations of beclomethasone-17-monopropionate (17BMP), which is one of the active metabolites of BDP, were 618 approximately 1, 749 pg/mL in 4 of the studied 5 patients, which was comparable to that after inhalation of BDP; however, it was relatively higher in one patient (2,439+/-161 pg/mL). As the blood concentration of 17BMP in this study patient was higher compared with healthy volunteers administered a single oral BDP 4 mg, GVHD patients might have a higher concentration than healthy volunteers. Given that a higher grade of gut GVHD was associated with a higher blood level of 17BMP, BDP absorption might be associated with gut mucosal injury. Thus, the systemic adverse effect following oral BDP administration might not be negligible especially in gut GVHD patients.
- Published
- 2010
38. [A review for recent advances in AA amyloid research and therapeutic approach to AA amyloidosis complicating rheumatoid arthritis].
- Author
-
Tamura H and Hasegawa K
- Subjects
- Amyloidosis etiology, Humans, Amyloidosis drug therapy, Arthritis, Rheumatoid complications, Serum Amyloid A Protein metabolism
- Abstract
AA amyloidosis is a life threatening clinical complication of chronic inflammatory diseases such as rheumatoid arthritis. It has been demonstrated biochemically that amyloidosis resulted from abnormal folding of proteins, which are deposited as insoluble fibrils in extracellular tissue, leading to the disruption of their normal function. In this regard, amyloidosis has been recognized as a conformation disorder. Interestingly, genetic polymorphisms of amyloid precursor protein (SAA) have been reported to associate with increased risk for AA amyloidosis. Also recent biochemical research revealed that SAA is synthesized under the influence of the proinflammatory cytokines, such as IL-6, TNF-alpha, IL-1. Additionally, it was suggested that amyloid deposits in extracellular tissue could reflect to the serum level of SAA in the reversible fashion, leading to the hypothesis that the control of the SAA synthesis could be beneficial to the treatment of amyloidosis. In this context, anti-cytokine therapies may be most effective. Especially the inhibition of IL-6 is critical to suppression of SAA production, so treatment with a humanized monoclonal antibody against human IL-6 receptor may not only ameliorate RA disease activity but also pave the way for the treatment of AA amyloidosis.
- Published
- 2009
- Full Text
- View/download PDF
39. [Evaluation of an adaptive filter for CT under low-CNR condition: comparison with linear filter].
- Author
-
Mori I, Uchida M, Sato A, Sato S, Tamura H, Takai Y, Ishibashi T, Saito H, Hosokai Y, Ogura T, Chida K, and Machida Y
- Subjects
- Image Enhancement, Tomography, X-Ray Computed instrumentation
- Abstract
The use of an adaptive filter for CT images is becoming a common procedure and is said to reduce image noise while preserving sharpness and helping to reduce the required X-ray dose. Although many reports support this view, the validity of such evaluations is arguable. When the linearity of a system is in question, physical performance indexes should be measured under conditions similar to those of clinical use. Evaluations of diagnosis using clinical images may be fallible because the non-filtered image used as the reference might not have been optimally reconstructed. We have chosen simple, but commonly used, adaptive filters for our evaluation. As a reference for comparing performance, we designed linear filters that best approximate the noise characteristics of the adaptive filters. MTF is measured through observation of the edge-spread function. Clinical abdominal images are used to compare the performance of adaptive filters and linear filters. We conclude that the performance of the type of adaptive filter we have chosen is virtually the same as that of the linear filter, as long as the image quality of soft tissues is our interest. Both the noise SD and MTF are virtually the same if the contrast of the object is not substantially higher than 150 HU. Images of soft tissues obtained with the use of adaptive filters are also virtually the same as those obtained by linear filters. The edge-preservation characteristic of this adaptive filter is not observable for soft tissues.
- Published
- 2009
- Full Text
- View/download PDF
40. [Two-year results of photodynamic therapy for choroidal neovascularization in young patients].
- Author
-
Fujisato K, Otani A, Sasahara M, Yodoi Y, Aikawa H, Tamura H, Tsujikawa A, and Yoshimura N
- Subjects
- Adult, Female, Follow-Up Studies, Humans, Middle Aged, Retrospective Studies, Time Factors, Treatment Outcome, Verteporfin, Choroidal Neovascularization drug therapy, Photochemotherapy adverse effects, Photosensitizing Agents therapeutic use, Porphyrins therapeutic use
- Abstract
Purpose: To study the safety and efficacy of photodynamic therapy (PDT) with verteporfin in treating choroidal neovascularization (CNV) in young Japanese patients., Methods: Ten eyes of 10 patients aged 50 years or younger with the diagnosis of CNV were retrospectively analyzed. CNV was of idiopathic origin in 8 eyes and of myopic origin in 2. Five eyes were treated with PDT. The visual, clinical, and angiographic responses and complications were investigated. Mean follow-up period was 33.2 months., Results: The initial mean best-corrected visual acuity (BCVA) was significantly worse in the PDT treated group than in the non-PDT treated group (0.55 vs. 0.21, p = 0.029). The mean CNV size was significantly larger in the PDT treated group (1752 microm vs. 782 microm, p = 0.014). BCVA improved in 40% (2 eyes), unchanged in 40% (2 eyes), and worsened in 20% (1 eye) in both PDT-treated and non-treated groups. No significant complications were observed., Conclusions: PDT seems to be a good treatment strategy in achieving a stable or improved vision for young CNV patients, even if they had very poor visual acuity at their initial visits. Further prospective studies are needed.
- Published
- 2008
41. [Clinical trials of Escherichia coli O-serogroup serodiagnosis in patients with diarrhea by Ec-LPS array].
- Author
-
Amano K, Tsutsumi R, Sato S, and Tamura H
- Subjects
- Adolescent, Child, Child, Preschool, Humans, Infant, Polysaccharides, Bacterial immunology, Diarrhea microbiology, Escherichia coli classification, Escherichia coli immunology, Escherichia coli Infections diagnosis, Escherichia coli Infections microbiology, O Antigens immunology, Serologic Tests methods, Serotyping
- Abstract
After developing the Ec-LPS array for Escherichia coli O-serogroup serodiagnosis (J. Jpn. Infect. Dis., 2007; 81: 26-32), we tested the array's usefulness in sera bled over 8 years ago from 24 patients with pediatric diarrhea. IgM and IgA antibodies in 20 sera among sera from the 24 reacted with a single LPS spot, making it possible to diagnose the O-serogroup. IgG antibodies in almost all patient sera reacted with many LPS among the 58 O-serogroup LPS of E. coli. O-serogroup strains of E. coli isolated from the 24 patients numbered 15. Among 11 patients in who O-serogroups were serodiagnosed by both methods, 7 were diagnosed with the same O-serogroups. Based on these results, this array appears useful in the O-serogroup serodiagnosis of E. coli.
- Published
- 2008
- Full Text
- View/download PDF
42. [Search of streptomycin-resistant bacteria in creek water and application of MALDI-TOF MS to grouping of the isolated bacteria].
- Author
-
Ichiki Y, Aoki T, Takashima Y, Tamura H, Teramoto K, Sato H, Arashidani K, and Yoshikawa H
- Subjects
- Bacteria classification, Drug Resistance, Bacterial, Polymorphism, Restriction Fragment Length, Spectrometry, Mass, Electrospray Ionization methods, Agrochemicals pharmacology, Anti-Bacterial Agents pharmacology, Bacteria drug effects, Bacteria isolation & purification, Rivers microbiology, Spectrometry, Mass, Electrospray Ionization instrumentation, Streptomycin pharmacology
- Abstract
A search of streptomycin-resistant bacteria was carried out using ten creek water samples collected in Saga prefecture by spreading the sample water on an R2A medium containing 10 microg/ml of streptomycin. It was clarified that such streptomycin-resistant bacteria as Bacillus, Novosphigobium, Sphingopyxis and Oceanobacillus were distributed in the creek water. Further, 60% of the isolates didn't form an inhibitory zone by the application of 700 microg/ml streptomycin solution in the cup method assay. Further, the effectiveness of the MALDI-TOF MS analysis for the grouping of the isolates was examined. The discriminating ability of MALDI-TOF MS analysis was higher than that of RFLP analysis and it was almost equal to that of sequence analysis using 16S rDNA. Considering the high-throughput ability of the MALDI-TOF MS instrument, MALDI-TOF mass spectral identification of bacteria will be a powerful method in the construction of a MALDI-TOF mass spectra database.
- Published
- 2008
- Full Text
- View/download PDF
43. [Double balloon endoscopy as a useful tool for the diagnosis and treatment of four cases of primary small intestinal lymphoma].
- Author
-
Tamura H, Ogata K, Kondo A, Wakita T, Inami M, Mizuki T, Hyodo H, Shioi Y, Nakamura K, Mitsui K, Tanaka S, Sakamoto C, and Dan K
- Subjects
- Aged, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal, Murine-Derived, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Combined Modality Therapy, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Fatal Outcome, Female, Humans, Male, Middle Aged, Prednisolone administration & dosage, Rituximab, Treatment Outcome, Vincristine administration & dosage, Catheterization methods, Endoscopes, Gastrointestinal, Endoscopy, Gastrointestinal methods, Intestinal Neoplasms diagnosis, Intestinal Neoplasms therapy, Intestine, Small, Lymphoma diagnosis, Lymphoma therapy
- Abstract
Primary small intestinal lymphoma (PSIL) is a relatively rare form of non-Hodgkin lymphoma, often complicated by bleeding, obstruction, or perforation of the intestine during the clinical course. The initial diagnosis and management of these complications are often difficult in PSIL, because the small intestine is usually inaccessible in routine endoscopy. Recently, total enteroscopy with a double-balloon method, called double balloon endoscopy (DBE), has been developed for the diagnosis and treatment of small intestinal disorders. We report herein on 4 cases of PSIL (2 diffuse large B-cell lymphomas and 2 follicular lymphomas [FLs]). In these cases, DBE was useful in the diagnosis, decision to perform surgery after assessment of bleeding lesion, and treatment of the intestinal stenosis using enteroscopic balloon dilatation. Combination chemotherapy consisting of anthracycline, cyclophosphamide, vincristine, and prednisolone with rituximab was administered in 3 cases, and all achieved complete remission. One patient with FL of the duodenum was treated with rituximab alone, but with little effect. We conclude that DBE is useful in the management of PSIL. More PSIL cases must be analyzed to establish the optimal management of patients with this form of lymphoma.
- Published
- 2007
44. [Therapeutic drug monitoring].
- Author
-
Ito T, Uchida Y, Tamura H, Hasebe S, Igarashi M, and Hayashi M
- Subjects
- Anti-Bacterial Agents administration & dosage, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Clinical Competence, Drug Administration Schedule, Humans, Patient Care Team, Professional Role, Risk Factors, Vancomycin administration & dosage, Vancomycin adverse effects, Drug Monitoring, Pharmaceutical Services, Pharmacists
- Abstract
Practicing pharmaceutical care is necessary to promote the appropriate use of medicines. In the practice of pharmaceutical care, monitoring the efficacy and safety of drugs from the pharmacists' point of view is an important role for clinical pharmacists and it is necessary to standardize clinical skills. We would like to introduce the monitoring skills of pharmacotherapy of clinical pharmacists by taking vancomycin injection and injectable anticancer drugs that have different monitoring points as examples.
- Published
- 2007
- Full Text
- View/download PDF
45. [Prevention and treatment for development and progression of diabetic macroangiopathy with pioglitazone and metformin].
- Author
-
Tamura H, Mokuno H, and Daita H
- Subjects
- Adiponectin, Arteriosclerosis etiology, Cardiovascular Diseases drug therapy, Cardiovascular Diseases etiology, Clinical Trials as Topic, Cytokines, Diabetic Angiopathies etiology, Disease Progression, Evidence-Based Medicine, Humans, Insulin Resistance, Macrophages, PPAR gamma, Pioglitazone, Arteriosclerosis drug therapy, Arteriosclerosis prevention & control, Cardiovascular Diseases prevention & control, Diabetic Angiopathies drug therapy, Diabetic Angiopathies prevention & control, Hypoglycemic Agents therapeutic use, Metformin therapeutic use, Thiazolidinediones therapeutic use
- Abstract
Prevention and treatment for diabetic macroangiopathy, causing the main etiology for mortality in patients with diabetes mellitus, is crucial target point, but is still controversial. Many clinical studies improving glycemic control by insulin and oral drugs were not demonstrating enough prevention for diabetic macroangiopathy to improve life prognosis. Insulin resistance is now considered to be major pathogenesis for diabetic macroangiopathy. The agents that improve insulin resistance, such as metformin and pioglitazone, have multiple effects to improve glucose and lipid metabolism by increasing sensitivity for insulin without increasing insulin secretion and exert anti-atherogenic properties resulting in preventing development of atherosclerosis. Some clinical studies such as UKPDS 34 and PROactive demonstrated preventive effects of these agents for diabetic macroangiopathy.
- Published
- 2006
46. [Posttubal ligation syndrome].
- Author
-
Tamura H and Sugino N
- Subjects
- Diagnosis, Differential, Edema, Fallopian Tube Diseases, Fallopian Tubes surgery, Female, Fertilization in Vitro, Humans, Menstruation Disturbances diagnosis, Menstruation Disturbances physiopathology, Menstruation Disturbances therapy, Prognosis, Syndrome, Uterine Hemorrhage diagnosis, Uterine Hemorrhage physiopathology, Uterine Hemorrhage therapy, Menstruation Disturbances etiology, Sterilization, Tubal adverse effects, Uterine Hemorrhage etiology
- Published
- 2006
47. [In vitro chromosome aberration test and in vivo micronucleus test of Ca-type Garcinia extract].
- Author
-
Ono H, Tamura H, Yamashita Y, Tamura K, and Iwakura K
- Subjects
- Animals, Cells, Cultured, Cricetinae, Cricetulus, Male, Mice, Plant Extracts toxicity, Chromosome Aberrations drug effects, Micronucleus Tests, Trigeminal Ganglion chemistry
- Abstract
The induction of chromosome aberration of Ca-type Garcinia cambogia extract containing about 65% (-)-hydroxycitric acid was investigated by use of the chromosome aberration test in cultured Chinese hamster lung cells (CHL/IU) and the micronucleus test in mice. In the chromosome aberration test, Ca-type Garcinia cambogia extract did not increase the number of cells with structural aberration and/or numerical aberrations. The micronucleus test was carried out with bone marrow cells of Slc : ddY male mice after single oral administration of up to 2,000 microg/kg. There was no significant increase in the frequency of micronucleated polychromatic erythrocytes. These results indicate that Ca-type Garcinia cambogia extract does not induce chromosome aberration.
- Published
- 2006
- Full Text
- View/download PDF
48. [Usefulness of MR diffusion imaging for evaluating brain tumors].
- Author
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Higano S, Tamura H, Mugikura S, Umetsu A, and Takahashi S
- Subjects
- Adult, Child, Diagnosis, Differential, Diffusion Magnetic Resonance Imaging methods, Evaluation Studies as Topic, Humans, Brain pathology, Brain Neoplasms diagnosis, Diffusion Magnetic Resonance Imaging standards
- Published
- 2004
- Full Text
- View/download PDF
49. [Spinal anesthesia with isobaric 0.5% bupivacaine for lower limb surgery: effects of different volumes].
- Author
-
Haranishi Y, Matayoshi Y, Yoshitomi K, Uchida M, Nakamura K, Oka H, Tamura H, and Shibasaki S
- Subjects
- Adult, Aged, Anesthetics, Local pharmacokinetics, Bupivacaine pharmacokinetics, Dose-Response Relationship, Drug, Female, Humans, Injections, Spinal, Male, Middle Aged, Solutions, Time Factors, Anesthesia, Spinal, Anesthetics, Local administration & dosage, Bupivacaine administration & dosage, Lower Extremity surgery
- Abstract
Background: The effects of different volumes (2.4, 2.6, 2.8 and 3.0 ml) of isobaric 0.5% bupivacaine used for spinal anesthesia were compared in 206 patients scheduled for lower limb surgery., Methods: The spinal anesthesia was performed with the patients in the lateral position and the isobaric 0.5% bupivacaine was injected intrathecally at the L3-4 interspace., Results: The time to maximum cephalad spread of anesthesia (loss of cold sensation) varied between 25 and 40 min. A significant difference was found in cephalad spread between 2.4 ml group and 3.0 ml group (T11 vs T7), and between 2.6 ml group and 3.0 ml group (T11 vs T7). Severe hypotension did not occur during the study., Conclusions: Spinal anesthesia with 2.8 ml of isobaric 0.5% bupivacaine proved satisfactory for lower limb surgery.
- Published
- 2004
50. [Mediastinal mass occurring 26 years after coronary artery bypass grafting].
- Author
-
Tamura H, Ohta H, Kojima S, Suwa S, and Nakata Y
- Subjects
- Aged, Aneurysm etiology, Angina Pectoris, Variant surgery, Graft Occlusion, Vascular etiology, Humans, Male, Tomography, X-Ray Computed, Aneurysm diagnostic imaging, Coronary Artery Bypass methods, Graft Occlusion, Vascular diagnostic imaging, Postoperative Complications, Saphenous Vein transplantation
- Published
- 2003
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