1. [Induction of CPT-11 in a patient on hemodialysis with metastatic rectal cancer].
- Author
-
Shinozaki E, Mizunuma N, Tanabe M, Chin K, Ota K, Ohkochi N, and Hatake K
- Subjects
- Antineoplastic Agents, Phytogenic adverse effects, Antineoplastic Agents, Phytogenic pharmacokinetics, Camptothecin adverse effects, Camptothecin pharmacokinetics, Drug Administration Schedule, Female, Granulocyte Colony-Stimulating Factor administration & dosage, Humans, Irinotecan, Kidney Failure, Chronic therapy, Leukopenia chemically induced, Lung Neoplasms metabolism, Lung Neoplasms secondary, Middle Aged, Neoplasm Recurrence, Local metabolism, Neutropenia chemically induced, Rectal Neoplasms metabolism, Rectal Neoplasms pathology, Rectal Neoplasms surgery, Antineoplastic Agents, Phytogenic administration & dosage, Camptothecin administration & dosage, Camptothecin analogs & derivatives, Lung Neoplasms drug therapy, Neoplasm Recurrence, Local drug therapy, Rectal Neoplasms drug therapy, Renal Dialysis
- Abstract
We report a case on hemodialysis with metastatic rectal cancer who was introduced to CPT-11. Although the expected pharmacokinetics was shown 24 hours post-dialysis with the infusion of dose-reduced CPT-11, grade 4 neutropenia was observed. Considering the chronic renal failure status with latent lower function of multiple organs, the dose escalation method was recommended while watching the pharmacokinetics. CPT-11 is not only the key compound for metastatic colorectal cancer, but is also effective with several other cancers. It is important for cancer patients with chronic renal failure that the feasibility and efficacy of CPT-11 should be determined by future study.
- Published
- 2005