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Ionizing radiation induces DNA double strand breaks followed by cell death. As a therapeutic modality, radiotherapy is an effective method for the cases surgically inoperable or ones with conservative treatment. However, recurrence and second cancer induction are major obstacles to radiotherapy. Our main goal is to establish more effective radiotherapy by elucidating whether recurrent cancers after radiotherapy are radioresistant or not, and molecular mechanisms of cancer induction by radiation exposure. We ultimately aim to establish therapeutical pathology. Therefore, we are concurrently trying to develop devices by which we can quantify histological images and support pathological diagnosis.