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混合ハーブ抽出物(MHE)は抗糖化作用が既に報告されている。HMEはローマカミツレ・セイヨウサンザシ・ドクダミ・ブドウ葉の熱水抽出物である。HMEは漢方薬とみなすことができる。漢方薬では、構成生薬の追加が元の効能を変化させることが知られている。HMEに生薬である生姜・山椒を加えカプセルに充填した試験食を作成し、それが抗糖化作用を示すか調べた。またQOLへの影響を調べた。対象者は12名で、血糖正常群8名(男:女1:7、平均年齢47歳)と糖尿病・高血糖群4名(男:女3:1、平均年齢51歳、HbA1c 5.7～7.0)の2群に分けられた。両群とも、HMEはエキス固形分240mgと生姜・山椒一定量を1日量として4カプセル・12週間摂取した。また各群の1名ずつは80週間摂取を継続した。抗糖化作用は皮膚AGEs蓄積を非侵襲的に測定し皮膚自発蛍光(AF)として示すAGE reader™により評価した。皮膚弾力はCutometerにより評価した。 抗加齢QOL共通問診表により「便秘」、「冷え性」、「体重減少」が有意(p=0.043)の改善または変化を認めた。皮膚AFは8週・12週にて両群とも減少し、血糖正常群では12週で有意(p=0.020)な低下を認めた。80週までの継続摂取では皮膚AF減少は継続した。12週での摂取終了は皮膚AFの悪化を認めた。皮膚弾力は糖尿病・高血糖群の12週でR2に若干の改善を認めた。MHEに2つの生薬を追加配合した処方は皮膚AGEs蓄積を抑制した。試験食の継続摂取は安全で有用な抗糖化法と考えられることが示唆された。, The anti-glycation effect of mixed herbal extract (MHE) was already reported. HME was produced using hot water extraction from Anthemis nobilis (Roman chamomile), Crataegus oxyacantha (hawthorn berry), Houttuynia cordata (dokudami), and Vitis vinifera (grape leaf). MHE can be regarded as a Chinese herbal remedy. In Chinese herbal remedy, it is well known that a little of additional crude drugs can change the original effects. We assessed whether a capsulated novel remedy of MHE with Zingiber officinale (syouga) and Zanthoxylum piperitum (sansho) showed an anti-glycation effect. We also assessed its effects on one's quality of life (QOL). The subjects consisted of 12 volunteers divided into two groups, the Normal Blood Sugar (NBS) Group (male: 1; female: 7; age: 47.3 ± 10.2 years) and the Diabetes Mellitus / Impaired Fasting Glycaemia (DM/IFG) Group (male: 3; female: 1; age: 51.5 ± 12.7 years) with HbA1c 5.7～7.0. Both of the Groups were administered 240 mg of MHE (solid substance) with certain amounts of Zingiber officinale (syouga) and Zanthoxylum piperitum (sansyo) in 4 capsules per day for 12 weeks. Two individuals - one of NBS Group and the other of DM/IFG Group - were administered continuously for 80 weeks. The inhibition of glycation was assessed by AGE reader™, non-invasively measuring the advanced glycation endproducts (AGEs) as skin auto fluorescence (AF). Also the skin elasticity was assessed by Cutometer. The analysis using the Anti-Aging QOL Common Questionnaire (AAQol) showed that the score for the parameters, “constipation", “cold skin", and “weight loss; thin" were significantly improved or changed (p=0.043). The skin AF decreased in the both Groups after 8 and 12 weeks respectively, and significant variation (p=0.020) was observed in the NBS Group after 12 weeks. Continuous intake for 80 weeks revealed continuing low values of skin AF. Stopping the intake at 12 weeks resulted in a deterioration of skin AF. The skin elasticity index R2 in the DM/IFG Group showed a slight improving tendency after 12 weeks. The novel remedy of MHE with additional two crude drugs inhibited the accumulation of AGEs in the skin. These results suggest that a continuous supplementation of the test product was considered to be a safe anti-glycation method.

薬用植物や生薬を利用することは、先人達の知恵の結晶であり、未来に受け継ぐべき財産である。しかし、近年の健康食品ブームは過熱気味のところがあり、薬用植物が安易に利用されている場合がある。そのため、植物部位の取り違いや、植物そのものの取り違いなどの問題も起きている。生薬の品質に関しては、色、味、匂いといった人の五感による選品が従来行われてきた。これに顕微鏡による形態観察、化学成分の確認、遺伝子解析が加わり、更には色差計、味覚センサー、匂いセンサーといった機械が導入されるようになってきた。機器による客観的な数値データが判断基準に変わりつつある。形態観察は古い技術ではあるが、顕微鏡があれば少量でも鑑別出来るなどの利点があり、流通の現場では薬用植物、生薬を理解する技術としてまだまだ重要な位置を占めている。, The utilization of medicinal plants and crude drugs is the crystallization of our predecessors' wisdom, which should be passed down as an asset to future generations. However, the recent health food boom is somewhat overheated and medicinal plants are sometimes used carelessly, incurring such problems as wrong identifications of plant parts and plants themselves. The five senses including color, taste, and smell have been used to determine qualities of crude drugs. Morphological observation by microscopy, chemical component determination, and genetic analysis are techniques additionally adopted for the determination. Furthermore, such equipments as colorimeters, taste sensors, and smell sensors have been introduced. Objective, numerical data obtained by the equipments are replacing sensory data as judgment criteria. Microscopic observation is an old technique. However, the technique has an advantage in that it requires only a small amount of a sample for identification and is still important for understanding medicinal plants and crude drugs in the field of distribution.

口腔内アフタ部の疼痛及び炎症が強く認められたため,温清飲とカンゾウを多く含んだ芍薬甘草湯を用い,長期にわたり,口腔内症状の軽減が認められたベーチェット病の1例を経験した

The botanical origin of Ginseng Folium (人参葉,Ren-shen-ye), a Chinese crude drug used for diseases of the viscera, is examined. The morphological and anatomical characteristics of the leaf and stem of Panax ginseng C. A. MEYER cultivated in China for 1 to 5 or 6 years are described. It is found that the vessels increase in number and diameter, and also the vascular bundles increase in number, as the plant becomes old. The result shows that the commercial "Ren-shen-ye" samples on the markets of Beijing, Kunming, Guilin, Chong-ging, Changsha and Hongkong have been derived from the leaf and stem of 3- to 5- or 6-year-old P. ginseng plants, most of them being 5- or 6-year-old. The commercial "Ren-shen-ye" derived from other Panax species will be reported in the next paper.