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Some observers have insisted that modern medicine should be restored to the holistic nature in the face of the limitations of the current mechanistic modern medicine. Four medical doctors trained in modern medicine, Simonton, Chopra, Kohda and Takeguma are showing the creative models of medicine based on the holistic philosophies and methodologies. It will be meaningful to investigate what the sociocultural backgrounds of their thinkings and practices are, and how much these are socially acceptable and useful.