1. Tc-Pertechnetate Scintigraphy Predicts Successful Postoperative Ablation in Differentiated Thyroid Carcinoma Patients Treated with Low Radioiodine Activities
- Author
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Luca Giovanella, Gaetano Paone, Teresa Ruberto, Luca Ceriani, and Pierpaolo Trimboli
- Subjects
Differentiated thyroid carcinoma ,Radioiodine ,Radionuclide imaging ,Sodium pertechnetate Tc 99m ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundPostoperative routine radioiodine (RAI) treatment is currently debated for patients with low-risk differentiated thyroid carcinoma (DTC) patients. If performed, a low 131I activity (i.e., 1 to 2 GBq) is recommended with the aim to ablate thyroid remnant and facilitate subsequent follow-up by thyroglobulin measurement. The purpose of this study was to evaluate the relationship between postsurgical technetium-99m (99mTc)-pertechnetate scintigraphy and the rate of successful remnant ablation after low activity radioiodine ablation in patients with DTC.MethodsEnrolled were 193 patients with low risk DTC who underwent total thyroidectomy and RAI ablation with a fixed 1.1 GBq activity of 131I. 99mTc-pertechnetate scans were done and thyrotropin stimulated thyroglobulin (sTg) levels measured just before ablation. Ablation effectiveness was assessed 6 to 12 months later by sTg measurement, neck ultrasound and diagnostic whole body scan.ResultsA negative 99mTc-perthecnetate scans was the best predictor of successful ablation (P
- Published
- 2019
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