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Introduction: Precocious puberty is characterized by the occurence of puberty signs before the age of 8 years in girls and 9 years in boys. Material and methods: This paper presents the case of O.M, female, 6 years, urban, followed-up in Clinic II Pediatrics since 4 years age, with isolated thelarche. The child's parents observed (at age 3 V2 six months) the development of the breast bilaterally and for that they addressed in an endocrinology service. Based on hystorical data, clinical and biological investigations and imaging the child was diagnosed with isolated thelarche (Waist = 93.5 cm (p25), Tanner Mil, right mammary gland GO = 3,5 / 3,5 cm, left mammary gland = 4 / 4 cm. FSH, LH, Estradiol, Progesterone, Testosterone, SHBG, TSH, FT4, hGH, IGF-1, Cortisol, Prolactin results within normal limits; left punch radiography bone age (BA) corresponding to the chronological age (CA). In evolution, after nine months (age 4 years and 3 months), the patient presented progressive increase in size of the breasts (MI / II PO/I - mammary gland left = 5/5 cm, right mammary gland = 4/4 cm) without other associated signs of puberty; at that moment they presented the child for exam in Clinic II Pediatrics. Clinical and biological evaluation revealed a corresponding height (p50), advanced bone age BA - CA =1.5 years. Hypothalamic-pituitary MRI revealed no pathological changes. We decided to monitor her biannually. In evolution, the breast continued to develop with the appearance of the pubic hair (Tanner PII). Revaluation that has been proceed on this occasion showed an accelerated growth rate 10 cm / year, advanced BA (BA-CA = 2 years), basal levels of the hormone FSH, LH, estradiol were normal, stimulation test with Triptorelin was negative. The ultrasound of genital organs revealed ovaries with numerous follicles and with a diameter less than 5 mm, uterus with infantile size. Conclusions: This case presents a particular evolution given by the clinical appearance suggestive for an ongoing puberty which do not match with the normal biological parameters. [ABSTRACT FROM AUTHOR]