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Although we have effective treatments for tobacco dependence, relapse is a frequent phenomenon in those who quit. The aim of this study was to analyze whether there were differences by gender in the relapse curve in men and women who participated in a cognitive-behavioral smoking cessation treatment. The sample was composed of 266 individuals (59.8 % women) who were abstinent at the end of treatment. The results indicate that as time after the intervention increases, the percentage of abstinent participant's decreases. However, no significant differences between men and women in the relapse curve were found, which could be explained by the inclusion of effective psychological tools to cope with some of the main causes of relapse (e.g., negative affect) in the treatment. Given the importance of relapse in the smoking cessation process, it is necessary to deepen in its triggers. [ABSTRACT FROM AUTHOR]