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Gerhard Henrik Armauer Hansen (1841-1912) worked on leprosy throughout his career. Following his discovery of the leprosy bacillus in 1873, he proposed legislation that, when enacted in 1877 and 1885, established preventive measures aimed at isolating infectious patients. Around 1920, leprosy was more or less eradicated in Norway after a period of decline starting in 1850. Over this period, more than 8,000 cases were registered. Armauer Hansen's unique research achievement was based on a scientific and medical infrastructure in place long before he started his work. This context had several implications, though the discovery of the leprosy bacillus holds a particular fascination, with bearings on the interaction between medicine and the community even today.

More than every second Norwegian 19th century physician made one or more study trips abroad. Some of them were probably more inspired by love of adventure than by the prospect of gaining new medical insight. This was probably also true of my great-grandfather, Eyvind Kraft. Shortly after completing medical school in 1879, he left Norway on the "Musca", an emigrant vessel, bound for Hawaii. He returned home approximately six years later to establish a sanatorium. In the meantime he worked as a ship's doctor, made a contribution to the understanding of the contagiousness of leprosy, and was among the founding members of the first medical society in the state of Wisconsin. Back in Norway he worked at the sanatorium, but also as a general practitioner and among fishermen during the seasonal fisheries. He had to travel to the Continent in an attempt to cure his "nerve disease". Eyvind Kraft's life tells an exciting story of exotic places and of the view of disease in his time.

During the 19th century leprosy was a serious health problem in Norway, especially in some western, rural districts. In 1856 it was decided that all leprous patients should be examined by the local doctor (District Health Officer), and registered in a national leprosy register. The patients' family relationships received special attention. Some patients tried to avoid registration, fearing that the data might be misused. After Armauer Hansen (1841-1912) discovered in 1873 that leprosy was an infectious disease, isolation of leprous patients was enforced. In 1884 Thomas Collett (1835-1898), the local doctor in a rural district of western Norway, carried out a survey of all leprous patients registered in his district, a total of 164 patients. The data from his survey provide convincing support for the view that hereditary factors play an important role in the development of the disease. Modern research has confirmed that an important gene controls the susceptibility to leprosy.

Armauer Hansen described his first observation of Mycobacterium leprae on 28 February 1873 in detail. His discovery of the leprosy bacillus was the result of a logical process in which distinct stages can be clearly seen. The first step was clinical, and established criteria for leprosy as "a specific disease". The second stage was epidemiological. Contrary to the main view favouring a genetic basis, these observations convinced him of the infectious nature of the disease. The third stage was the search for the bacillus. His basic observations were reproduced, as documented. Armauer Hansen afterwards tried to fulfill Koch's postulates, in order to prove that the bacillus was the causative agent of leprosy. His second main contribution is the work on leprosy control, emphasizing isolation to contain the infection. The subsequent decline of leprosy in Norway differs from the trend in many developing countries, where leprosy has remained an important public health problem. In recent years Norwegian medical research has made significant contributions to leprosy research, in the field of epidemiology in Bergen, and through immunological studies of the disease originating from the Armauer Hansen Research Institute in Addis Ababa, Ethiopia.