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Background: The relation between angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and cardiovascular diseases was reported previously but the role of this polymorphism and the occlusion of vein grafts in long-term post coronary artery bypass graft (CABG) surgery still has remained controversial. The aim of the present study was to investigate any probable relationship between ACE I/D polymorphism and the atherosclerotic occlusion of vein grafts. Methods: Patients who undergone CABG surgery more than five years ago, participated in this crosssectional study. Occlusion of vein graft was determined by angiography. The ACE I/D polymorphism was detected by polymerase chain reaction (PCR) based restriction analysis. Findings: A total of 102 patients (84 males) were enrolled to the study. The frequency distribution of DD, ID, and II polymorphisms were 23.6%, 62.7%, and 13.7%, respectively. There were no differences among genotypic groups regarding the number of occluded, diseased, and atherosclerosisfree vein grafts (P = 0.6, 0.7, and 0.18, respectively). Patients with II genotype had the same number of completely occluded vein grafts in a marginally significant shorter time after CABG (P = 0.06) compared with the other groups. Conclusion: Although the results of our study indicated no association of ACE I/D polymorphisms and the occlusion of vein grafts long-term post-CABG, ACE II genotype may accelerate the rate of occlusion in vein grafts. [ABSTRACT FROM AUTHOR]

Background: Interleukin-6 (IL6) gene polymorphism is an important inflammatory cytokine. It may play a major role in complications observed after CABG surgery. Therefore, the present study was designed to study the relationship between IL6 174G>C gene polymorphism and complications after CABG. The aim of this study was to investigate any probable relationship between IL6 174 G >C polymorphism and complications observed after CABG surgery. Methods: In this case-control study, whole blood samples were obtained from all patients hospitalized for CABG surgery in Sina Hospital, Isfahan. Subject were divided into two groups of patients with (POC) or without (NPOC) complications. Information such as age, sex, degree of hemorrhage after the surgery, time spent in the intensive care unit (ICU), ventilation time, and inotropic support after the surgery was collected. Statistical analysis of the obtained data was performed using t-test and chi-square test. Findings: We did not find a correlation between IL6 gene polymorphism and complications after CABG surgery (P = 0.126). However, a significant difference was observed. This difference for GG was P = 0.05 and for GC was P = 0.035 between two groups. Conclusion: GG genotype may play a role for the inflammation and complications after CABG. Further studies with larger number of patients are recommended. [ABSTRACT FROM AUTHOR]