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Following the discovery and spread of the novel coronavirus (nCoV-2019), the cause of a respiratory illness from Wuhan, Hubei province in China, extensive research has been done for identifying, preventing and treating the illness caused by this virus. The information on this virus is being updated every moment. Identifying the sources of contamination and the routes of transmission is one of the requirements for accurate prevention of infection. The original source of nCoV-2019 is still unknown and efforts are ongoing in this regard. Early detection and control of the sources of infection in the emergency department is crucial. In addition to the standard cautions, further infection prevention and control (IPC) should be initiated according to the protocols by world health organization (WHO) on presentation of suspected cases. The aim of this letter is introducing solutions for initial detection and prevention of the spread of the novel coronavirus in emergency department as the first line of dealing with patients in the hospital by adapting WHO recommendations. [ABSTRACT FROM AUTHOR]