Search

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. The prevalence of PCOS among Iranian women is 14.6% based on the Rotterdam definition. PCOS can increase the risk of chronic metabolic complications. Metabolic syndrome (MetS) is one of the most important of them. Insulin resistance is fundamental in PCOS and MetS pathophysiology. MetS is a collection of chronic metabolic derangements, which promotes the risk of serious diseases such as cardiovascular disturbances and diabetes. The quality of diet is inversely correlated with obesity, which is one of the consequences of PCOS and it is a risk factor for metabolic syndrome. As the first study, the present study aimed to compare the dietary intake of macronutrients in PCOS women with and without MetS. Methods: In this nested case-control study, the convenience sampling method was used to select participants. The case group included 14 PCOS patients with MetS and the control group included 28 PCOS patients without MetS. The investigated macronutrients included fats (total fat, saturated fatty acids, mono and polyunsaturated fats, trans fatty acids), carbohydrate, protein, and fibers (total and soluble). The dietary intake assessment was carried out by a 168-item semi-quantitative food frequency questionnaire (FFQ). This study was performed on Arash Women's Hospital under support of Tarbiat Modares University, Tehran, Iran, from August 2014 to September 2015. Results: Dietary intake of total fat was significantly higher in PCOS women with MetS than the control group (P

Introduction: Flavonoids include a large number of plant-based polyphenolic compounds with antioxidant, anti-estrogenic, anti-mutation, and anti-proliferative effects. This study was conducted to evaluate the relationship between endometriosis and dietary flavonoid intake among Iranian women referring to Arash Hospital, Tehran, Iran,from May 2016 to February 2017. Methods: This case-control study was conducted on 156 women (78 women diagnosed with endometriosis after laparoscopy and 78 healthy women) in Arash Hospital. The dietary data of the subjects were obtained using a 147-item semi-quantitative Food Frequency Questionnaire a year before the interview. The USDA tables were used to determine the type and amount of flavonoids per 100 g of each food item. Data were analyzed using the Chi-square، t-tests, and logistic regression model. Result: After the adjustments of the confounding variable, it was revealed that individuals who had a higher intake of total flavonoids ‎(P=0.001)‎ were less likely to have endometriosis‎. Among the subgroups of flavonoids, the only intake of flavanone ‎(P=0.04)‎ was significantly associated with ‎endometriosis risk. Regarding different food groups, flavonoid was significantly lower in the dairy product ‎(P=0.02), adviser ‎(P=0.001), and fruit ‎(P=0.03), compared to that of the control group. Conclusion: Regarding the influence of flavonoid intake on endometriosis pathogenesis, it can be concluded that a higher intake of flavonoids can contribute to the prevention and control of endometriosis. Therefore, it is recommended to conduct counseling sessions about the benefits of flavonoid intake for such patients.