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Background and Objectives: Epilepsy is the most common neurological disorder after a stroke, which causes recurrent seizures. The aim of the present study was to evaluate Memory deficits and mood disorders, such as depression and anxiety are commonly seen in patients with epilepsy. The aim of this study was to evaluate the effectiveness of Iranian Artemisia persica essential oil on memory deficits, depression, and anxiety in pentylenetetrazole (PTZ) kindled male mice. Methods: In this experimental study, 70 male mice, were randomly divided into 7 groups: normal saline group, epilepsy model that received PTZ (35mg/kg) every other day with 48h intervals for 9 day and then the essential (at a dose of 60mg/kg) on the 10th day. treatment groups that received PTZ with 48h intervals and essential oil (at doses of 50, 75, and 100mg/kg) daily, positive control group that received PTZ with 48h intervals and essential oil (dose, 100mg/kg) daily and diazepam on the 10th day, 30 minutes before the injection of PTZ. Flumazenil group received PTZ with 48h intervals and essential oil (dose, 100mg/kg) daily and flumazenil on the 10th day, 30 minutes before the injection of PTZ. One way ANOVA and Tukey tests were used for data analyze. Results: Artemisia persica essential oil (dose, 50mg/kg) caused a significant increased delay in the onset of seizures in the mice that received PTZ (p

Introduction The aim of this study was to investigate the effect of Artemisia persica (AP) extract on seizure and behavioral problems induced by PTZ in male rats. Materials and Methods 70 male mice were randomly divided into the seven groups including control (normal saline), model (PTZ at a dose of 35 mg/kg with 48h intervals and at 60 mg/kg on the 10th day), intervention groups (PTZ with 48h intervals and extract at doses of 100, 200 and 400 mg/kg daily) and flumazenil and diazepam groups (PTZ, extract at 400 mg/kg and flumazenil or diazepam on the 10th day). Tail suspension test (TST), rotarod, elevated plus maze (EPM) and open -filed were used to evaluate behavioral disorders. Results Treatment of PTZ-kindled mice with Artemisia persica extract and diazepam caused a significant increase in a seizure onset time (P

Background and Aim: Gastric cancer is addressed among developing countries as a public health problem. The relationship between ABO blood groups and cancer has been proven years ago. According to various studies, the incidence of gastric cancer is higher in people with blood group type A. In this study, the relationship between ABO blood groups and gastric cancer; staging and tumor subgroups were studied. Materials and Methods: This cross-sectional study was conducted on 100 patients with gastric cancer who were confirmed by histopathology. The relationship between ABO blood groups and staging and type of pathology of the tumor and its gastric adenocarcinoma subtypes including diffuse and intestinal type were studied. Statistical analysis was performed using chi-square test and SPSS software. Findings: The results showed that the incidence of stomach cancer in people with blood group type A is greater. The study showed that there was a significant relationship between blood groups and gastric cancer (p> 0.05). Also, the study showed that there is no significant relationship (p= 0.55) between blood groups and types of tumor subgroup. Moreover, there was no significant relationship between blood group and tumor differentiation (p = 0.12). Conclusion: This study showed that there is a relationship between blood group A and gastric cancer. Considering the higher prevalence of gastric cancer in people with blood group A, identifying and eliminating other risk factors for cancer, is necessary.