Background: Recently, the prevalence of metabolic syndrome in societies is increasing. In this study, we investigated the association between metabolic syndrome and the severity of chronic obstructive pulmonary disease (COPD) based on the Global Initiative for Chronic Obstructive Lung Disease 2017 (GOLD 2017) criteria for outpatients. Methods: In this cross-sectional study, 96 patients with COPD to Alzahra hospital in Isfahan, Iran, during the years 2016 and 2018 were enrolled. The severity of COPD in patients was determined based on the GOLD 2017 criteria, as well as the frequency of metabolic syndrome. Other factors such as lipid profiles, anthropometric characteristics were evaluated, and the association between severity of COPD and metabolic syndrome with other variables were studied. Findings: The frequency of metabolic syndrome in patients with COPD was 86.5%. The mean of waist circumference, fasting blood sugar (FBS), systolic (SBP) and diastolic blood pressure (DBP), body mass index (BMI), and triglyceride in patients with metabolic syndrome and COPD were significantly higher than patients with COPD without metabolic syndrome (P < 0.050). Moreover, there was no significant relationship between COPD severity and metabolic syndrome (P > 0.050). Conclusion: Metabolic syndrome was not associated with severity of COPD based on our findings, and further studies are needed.