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Background: Neonatal deaths stand for almost two-thirds of all deaths occurring in infants under one year of age. Congenital anomalies are responsible for 24.5% of these cases forming a highly important issue for health policy-makers.Methods: We studied the pre-, peri- and post-natal conditions of 77 patients with multiple congenital anomalies (MCA) through genetic counseling at Several university Hospitals, in Tehran, Iran. The collected data were subsequently analyzed using SPSS software. Results: The patients did not have a good prognosis, demonstrating the need for the diagnosis of such diseases early in pregnancy to be of utmost importance. We screened for trisomy and nuchal translucency, which the first showed a low risk and the second showed normal results in most cases.Conclusion: Establishment of standards for prenatal diagnosis of congenital anomalies and monitoring their implementation seem to be necessary for the reduction of deaths due to congenital anomalies and infant mortality rate (IMR).

Background: The first duty of any government is to ensure the health of its children and neonates. Today's countries are classified as declining mortality in this group. To increase neonatal survival rate, classified causes of newborn mortality are the Core Strategy and Policies. This study was aimed to determine the classification of causes of neonatal death in Iran. Methods: Neonatal mortality refers to deaths of young children, typically those less than 28 days of age. It is measured by the neonatal mortality rate (NMR), which is the number of deaths of neonates per 1000 live births.This study was used data from 11693 neonatal deaths (from 22 weeks gestational age to neonatal death less than 30 days), in IRAN's hospitals in 2012 that registered in the Perinatal Mortality Surveillance System (hospital-based system). Demographic characteristics and other factors associated with neonatal death were investigated. To aid in cause of death analyses, burden of disease analyses, and comparative risk assessment we classified the causes of death according to International statistical classification of diseases version 10 (ICD 10), divided into three cause mortality strata. Results: The most common cause of neonatal mortality was "certain conditions originating in the perinatal period" (77.92%) with the highest incidence of "disorders related to length of gestation and fetal growth" (37.7%) in this group. Also 2419 (20/82%) of deaths caused by "Congenital malformations, deformations and chromosomal abnormalities" and 147 (1/26%) cases had occurred as a result of "accidents and injuries". The greatest cause of death in the neonates with weight over one thousand grams was "certain conditions originating in the perinatal period" (71/29%), with the highest percentage in the disorders related to "length of gestation and fetal growth" (29/65%). Conclusion: Policies and interventions should be in line with the priority given to the most common causes of death in prenatal care, prevention and treatment of complications of pregnancy and delivery.