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Background and Objective: Thalassemias is the most common inherited disease in the world. This study was designed to assess general health of patients with beta-thalassemia major in Gorgan, northern Iran. Materials and Methods: This descriptive study was performed on 163 patients with beta-thalassemia major whom referred to Thalghani hospital in Gorgan, northern Iran. Socio-Psychosocial status of patients was assessed by using general health questionnaire-28 (GHQ-28). Results: Socio-Psychosocial status of 44.2%, 46% and 9.8% of patients was normal, suspected and suffered from psychosocial disorders, respectively. Social dysfunction (12.9%) and depression (10.4%) were the most prevalent and anxiety was the less prevalent (4.9%) in the patients. There were significant correlations between psychosocial status and mother’s ocupation (P

Background : Pregnant women with high level of anxiety are likely to give birth to babies who are irritable, restless, have sleep disorders and low birth weight. Objective : To determine the relation of psychosocial status of women during pregnancy and pregnancy outcomes. Design : This was a comparative study. Data were collected using a questionnaire. Samples : 360 subject nuliparas to multiparas 4, were selected through consequative sampling, 180 in each group (appropriate and inappropriate psycholocial status). Results : There was a relation between psychosocial status of mothers and LBW (p=0.005), IUGR (p=0.028) and preterm labor (p=0.000). Conclusion : Emotional support by family and health care providers should be targeted at women with poor psychosocial status during pregnancy in order to decrease their emotional distress and to enhance their self- esteen and self- confidence.