1. Nadwrażliwość na niesteroidowe leki przeciwzapalne (NLPZ) - klasyfikacja, rozpoznawanie i leczenie: przegląd EAACI/ENDA# i GA2LEN/HANNA.
- Author
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KOWALSKI, M. L., MAKOWSKA, J. S., BLANCA, M., BAVBEK, S., BOCHENEK, G., BOUSQUET, J., BOUSQUET, P., CELIK, G., DEMOLY, P., GOMES, E. R., ROMANO, A., SANCHEZ-BORGES, M., SANZ, M., TORRES, M. J., DE WECK, A., SZCZEKLIK, A., BROCKOW, K., and NIŻANKOWSKA-MOGILNICKA, E.
- Subjects
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NONSTEROIDAL anti-inflammatory agents , *DRUG allergy , *DRUG side effects , *IMMUNOLOGY , *DISEASE management , *ASTHMA , *SINUSITIS , *ANAPHYLAXIS - Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hyper-sensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2011