Search

Despite the constant development of diagnostic and therapeutic methods, there is no specific test for patients with head and neck carcinoma, which can help in the early diagnosis, monitoring of the follow ups. The thesis of that paper were accompanied with remark that in many cases there is a level of change of some acute phase protein and immunity immunoglobulins. The research group consisted of 146 men and 15 women, together 161 patients with head and neck carcinoma. 114 patients with larynx carcinoma, 32 with oral carcinoma, 7 with carcinoma of ethomaxillary area, 6 with parotid gland carcinoma and 2 with ear carcinoma. Patients were divided into 5 groups. The first group (52 patients) with diagnosed carcinoma before treatment, second group (33 patients) with confirmed recidivation after treatment, third group (20 patients) after radiotherapy with no recidivation, fourth group (31 patients) after surgery treatment with no recidivation, fifth group (25 patients) after combined treatment with no recidivation. Sixth group (30 patients) was a control group. Particular acute phase proteins serum level were measured; C-reactive protein (CRP), haptoglobin (HPT), transferrin (TRF), protein C3 complement, immunity albumin's IgA, IgG, IgM. The results of five groups were compared with results of control groups. One of the ground of the statistically analyzed results were possible to draw such conclusions: 1. C-reactive protein, haptoglobin, transferrin serum levels have a significant correlation to carcinoma process. 2. Manifestation of carcinoma recidivans after treatment causes statistically significant change of C-reactive protein and haptoglobin concentration. 3. After radical antineoplasmatic treatment there is a return of C-reactive protein and haptoglobin concentration to normal level. 4. Protein C3 complement and immunity immunoglobulins medium serum levels were normal and there were no differences compare to control group.