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Growth hormone (GH) regulates metabolic processes, modulates the growth of the body, stimulates cell proliferation and differentiation. Human recombinant growth hormone is administered in growth disorders related to GH deficiency, wound treatment, as well as, contrary to the recommendations, in aesthetic medicine. GH and IGF affect skin homeostasis, primarily through the influence on the dermis and synthesis of collagen fibers but also on the epidermis and appendages of the skin. GH and IGF have also been shown to be involved in the pathogenesis of skin lesions and diseases, primarily of the proliferative basis. Particular attention is paid to the proven positive effects of GH, IGF-I and IGF-II on the healing process, including wound healing. The work outlines the effects of GH i rhGH on skin processes, skin diseases, chronic wound healing, the occurrence and dysplasia of melanocytic nevi and also describes the role of GH in melanoma pathogenesis and metastasis. [ABSTRACT FROM AUTHOR]

Emollients are topical agents with moisturizing, lubricating and smoothing properties. The most important action of emollients is restoring the disturbed epidermal barrier. This effect is achieved by various mechanisms: occlusive properties, attraction and keeping the water within the stratum corneum and supplying the physiological lipids and peptides, that lack in the disturbed epidermis. The final effects of emollients are reduction of inflammation, decrease of pruritus and better appearance of the skin. Emollients are the essential part of the therapy of many inflammatory skin diseases with disturbed epidermal barrier. They are used in the treatment of atopic dermatitis, psoriasis, keratinization disorders, chronic eczema, pruritic diseases and many other dermatoses. Emollients are often the adjuvant therapy, which is used together with topical corticosteroids or calcineurin inhibitors. There are several possible types of therapy: continuous, intermittent or proactive. This paper summarizes the knowledge about emollients, their mechanisms of action, the indications and proper way of application. [ABSTRACT FROM AUTHOR]

The cutaneous mucinoses belong to the heterogenous group of diseases characterized by mucin accumulation in the dermis. Reticular erythematous mucinosis is a primary cutaneous mucinosis with typical clinical and histopathological features. A 34-year-old patient with clinical and histopathological picture which may point to reticular erythematous mucinosis has been reported. [ABSTRACT FROM AUTHOR]