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The article presents the utilization of SLIT in the immunotherapy of respiratory allergies based on: (1) EAACI 2017 guidelines formulated using AGREE II (Appraisal of Guidelines for Research and Evaluation), dedicated to the assessment of the efficacy of allergen immunotherapy in the treatment of allergic rhinitis and bronchial asthma, (2) current AAAAI recommendations concerning SLIT, (3) systematic reviews and meta-analyses by Dhami et al., published in 2017. Drawing on these sources, the following issues have been dealt with: current recommendations and contra-recommendations for SLIT in respiratory allergies, short- and long-term efficacy of SLIT, recommendations regarding the use of specific forms of SLIT application, wiz. aqueous solutions and sublingual tablets, recommendations regarding different SLIT protocols and safety of this form of therapy. Additionally, expert opinions on the uses of SLIT in the case of polyvalent allergy and sensitization. Adherence in SLIT has been highlighted based on the most recent "real life" Breath study. [ABSTRACT FROM AUTHOR]

Introduction. The results of recent metaanalyses showed the effectiveness of SLIT (sublingual immunotherapy) in allergic rhinitis and asthma in children allergic to grass pollen. However, in some meta-analyses high variability of the results of these trials weaken the power of conclusion. In the present study we used the highest dose of extract (of the ones registered in Poland). Aim of the study. To study the efficacy and safety of sublingual immunotherapy given pre-coseasonally (starting before the pollen season and continuing until the end of it) and its effect on inflammatory parameters in children with rhinitis allergic to grass pollen. Materials and methods. Thirty children, recruited from our outpatient allergy clinic, with rhinitis, sensitive to grass pollen, participated in the 2-year prospective, randomized, double-blind, placebo-controlled trial. All patients were randomized according to a computer-generated allocation schedule into the two treatment arms: the pre-coseasonal SLIT group (n= 15) (Staloral 300 IR, Stallergenes), and the placebo group (n=15). We analyzed the effect of SLIT on allergic rhinitis and ocular symptoms, the use of rescue medication, lung function, FENO and bronchial hyper-reactivity. Results. In the second year of immunotherapy we observed the reduction of nasal and ocular symptoms, significant decrease in the use of rescue medication and FeNO level as compared to the placebo group and to the first year of immunotherapy. We did not observe any significant changes in the lung function and bronchial hyper-reactivity after immunotherapy. Conclusions. The applied regimen of SLIT was effective and safe in children with rhinitis allergic to grass pollen. The results suggest that the measurement of FENO level is clinically useful in monitoring SLIT in children. [ABSTRACT FROM AUTHOR]

Specific immunotherapy is the casual method of the treatment of atopic and allergic diseases, and sublingual immunotherapy (SLIT) is the form of SIT, often and willingly used. The authors present the case study of psoriasis induction after 13 years from remission, during the treatment by sublingual immunotherapy in a 18–year–old patient. [ABSTRACT FROM AUTHOR]

Sublingual immunotherapy is an efficient and safe method of treating atopic allergic diseases. Patient's self-immunotherapy is associated with the risk of wrong dose and incorrect drug intake timing, which can be dangerous to patient's life. This paper reports a case of 16-years old girl who developed anaphylactic shock after overdosing of sublingual allergen vaccine. [ABSTRACT FROM AUTHOR]