Search

We report a case of a hemolytic disease in a newborn from the first pregnancy due to anti-D antibodies. The maternal blood group was A Rhesus negative. She had an antibody screening test twice during the pregnancy (in the second trimester) and it was negative. The pregnancy was uneventful, without any invasive procedures and bleeding. The infant was born at 39 weeks of gestation in good overall condition. After the delivery the blood group of the neonate was indicated - A Rhesus positive, BOC positive. Anti-D antibodies were detected in maternal blood. Neonatal blood tests revealed severe anemia (hemoglobin level: 6.0g/dl, hematocrit: 22.2%, erythrocytes: 2.01T/L). During the first day of neonatal life, the newborn received two transfusions of red blood cells. Bilirubin level and rate of rise were not recommendation enough for exchange transfusion. The newborn was treated with continuous phototherapy since the delivery The perinatal period was complicated with intrauterine infection and respiratory failure. Hematopoietic vitamins and iron supplementation was initiated in the second week of neonatal life due to persistent anemia. The child remained under medical care of a hematologic clinic and received human recombinant erythropoietin treatment.

One of the biggest challenges facing modern oncology is that of delivering drugs selectively to cancer cells and tumor endothelial cells. To achieve this goal, one can use peptides binding certain molecules on these cells. The most often used method of creating such peptides is phage-display. Peptides obtained from phage display technology can exert anti-cancer effect by inhibiting angiogenesis, decreasing tumor metastatic activity, or inhibiting enzymes important for neoplastic cell spread. They can also be used as components of antitumor vaccines or vehicles delivering cytokines, chemotherapeutics, or anti-sense oligonucleotides to tumors. Phage display technology has also enabled the development of anti-cancer recombinant antibodies, most often used as scFv molecules. ScFv-s can be further modified to increase their affinity and avidity. They can also be conjugated with molecules inducing different anti-cancer effector functions.

Different antiproliferative agents: 5-fluorouracil, mitomycin C, growth factors antibodies, cyclosporine A, used as an adjunct to improve the success rate in filtering surgery and most common complications associated with them, are described.