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We describe the case of a 33-year-old patient with cutaneous lupus erythematosus admitted to the Department of Neurology due to the weakness of right limbs and speech disorders after night sleep. On admission, neurological examination revealed: no verbal contact; mixed aphasia with motor predominance; wide, symmetrical and reactive pupils; conjugate gaze palsy in a horizontal direction; right-sided hemianopsia and right-sided pyramidal tract syndrome with right limbs paralysis and bilaterally positive Babinski's sign. Magnetic resonance imaging revealed changes in the type of fresh ischemia in the left hemisphere of the brain – in the temporal lobe / basal ganglia on the left side hyperintensive areas were visible. As a result of the therapy and rehabilitation, the patient's general and neurological condition was improved. The patient was discharged home with recommendations in good general condition.

Lupus erythematosus is an autoimmune disease characterized by complex immune disturbances concerning humoral and cell-mediated immune responses. Despite intensive research, many pathological processes regarding this disorder remain unexplained. During interdisciplinary investigations on the etiology of lupus and its complications special interest has recently been referred to heat-shock proteins, antibodies directed against such proteins and galectin-3. These issues are extensively studied not only by dermatologists and rheumatologists, but also by cardiologists (in terms of cardiovascular complications) and nephrologists (in terms of lupus nephritis). This study presents the current state of dermatological, nephrological and cardiological knowledge on this topic.

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