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Your search keyword '"Etidronic Acid pharmacology"' showing total 2 results
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2 results on '"Etidronic Acid pharmacology"'

1. [Osteoporosis treatment: choices and options].

Author

Reginster JY

Subjects
Alendronate pharmacology, Bone Density drug effects, Bone Density Conservation Agents pharmacology, Clinical Trials as Topic, Etidronic Acid pharmacology, Etidronic Acid therapeutic use, Humans, Osteoporosis therapy, Risedronic Acid, Treatment Outcome, Alendronate therapeutic use, Bone Density Conservation Agents therapeutic use, Etidronic Acid analogs & derivatives, Osteoporosis drug therapy
Published
2007

2. [Effect of bisphosphonates (HEBP, CL2MBP) on the process of biological mineralization in fresh bone and bone tissue de novo as a result of experimental osteogenesis induction in guinea pigs].

Author

Wojtowicz N, Kamiński A, Sotowski R, Dziedzic-Gocławska N, and Stachowicz W

Subjects
Animals, Bone Transplantation, Disease Models, Animal, Guinea Pigs, Ossification, Heterotopic prevention & control, Osteogenesis drug effects, Transplantation, Heterotopic, Urinary Bladder, Calcification, Physiologic drug effects, Clodronic Acid pharmacology, Etidronic Acid pharmacology
Abstract

It is known from the literature that bisphosphonates inhibit mineralization process in skeletal tissues. To study in vivo the effects of HEBP (etidronate) and Cl2MBP (clodronate) both on preexisting bone mineral as well as on the early stages of the mineralization process the experimental model of heterotopical bone induction was chosen. Urinary bladder mucosa was used as an inductor of osteogenesis. Using this model it is possible to compare the effects of bisphosphonates on preexisting mineral on ortothopic bones as well as on the early stages of mineral deposition in the newly formed bone induced in heterotopic sites. HEBP and Cl2MBP doesn't inhibit heterotopic bone induction, but HEBP deeply inhibits the mineralization process; the small amount of deposited mineral does not contain crystalline fraction.

Published
1995

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