1. [Biological role of HLA-C].
- Author
-
Kuśnierczyk P
- Subjects
- Animals, Antigens, Viral immunology, Base Sequence, Humans, Killer Cells, Natural immunology, Molecular Sequence Data, Peptides metabolism, Polymorphism, Genetic, T-Lymphocytes immunology, HLA-C Antigens immunology
- Abstract
Human major histocompatibility complex class I molecules, HLA-A and -B, bind peptides derived from intracellular proteins, transport them to the cell surface and present them to T lymphocytes. Much less is known about the function of the third "classical" class I molecule, HLA-C. Recent data disclosing remarkable polymorphism of HLA-C, possible importance of this molecule for the recognition of target cells by nature killer cells, and capability to present viral antigens to the T lymphocytes are reviewed. Preliminary results from our laboratory on binding of synthesis peptides to HLA-Cw3+ cells are presented.
- Published
- 1995