1. [Molecular aspects of the etiopathogenesis of the parathyroid gland diseases].
- Author
-
Lacka K
- Subjects
- Chromogranins, GTP-Binding Protein alpha Subunits, Gs, Genetic Predisposition to Disease, Humans, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ret, Receptors, Calcium-Sensing, Tumor Suppressor Proteins, Hyperparathyroidism genetics, Hypoparathyroidism genetics, Parathyroid Neoplasms genetics
- Abstract
Current views on the molecular aspects of familial parathyroid gland diseases have been presented (familial primary hyperparathyroidism, hypoparathyroidism and psuedohypoparathyroidism). Their inherited mode and genetic abnormalities have been described. Particularly, the following genes: HRPT2, MEN1, RET, CASR, GNAS have been shown. Localization, structure, expression and structural changes (mutations) found in patients with familial parathyroid gland diseases have been presented. Attention has been paid to clinical and histopathologic symptoms, which should indicate the need to undertake genetic studies.
- Published
- 2005