1. [Protective role of leptin in acute gastric ulcers].
- Author
-
Ptak-Belowska A, Brzozowski T, Pajdo R, Pawlik M, Kwiecień S, Drozdowicz D, and Pawlik WW
- Subjects
- Acute Disease, Animals, Random Allocation, Rats, Rats, Wistar, Regional Blood Flow drug effects, Stomach Ulcer prevention & control, Anti-Ulcer Agents administration & dosage, Gastric Mucosa metabolism, Leptin administration & dosage, Leptin metabolism, Stomach Ulcer drug therapy, Stomach Ulcer metabolism
- Abstract
There are few data concerning protective effects of leptin on gastric epithelium treated with necrotic factors: ethanol, bile salts and hiperosmotic solutions. Further investigations are needed to establish the role of hormone leptin in gastroprotection and in the process of chronic gastric ulcers healing in animals. Exogenous leptin administration plays protective effects against 75% ethanol damage in gastric epithelium. Nitric oxide is involved in gastroprotective effects of leptin and CCK.
- Published
- 2008