Search

The history of development of health resort Druskieniki basing on Adam Wrzosek, an eminent Polish historian of medicine pointed out. The beauty and advantages of this health resort is depicted widely. The living and professional achievements of Jan Pilecki (1821-1878), an eminent physician of health resort, his significance for development and of Druskieninkai are presented in more detail. The medical indications and contraindications in Druskieniki basing on his own experiences have been reported. Pilecki was a author of many medical publications in Polish medical magazines. His papers contained interested medical observations and description of social life and entertainments in this health resort.

Lymphocytes extravasation is determined by their adhesion to the endothelial cells. The process goes along with high degree selectivity and is limited to lymph nodes and lymphatic tissue. It comes to uncontrolled extravasation to the tissues of involved organs in diseases with allergic origin as well in inflammation. Most information concerning adhesive interactions comes from researches dealing with normal lymphocytes. However, this phenomenon plays also crucial role in inflammation, metastasis and other pathologies. The aim of the work was to search for the possible distinct efficacy of adhesive interactions between peripheral blood lymphocytes from children with asthma and endothelial cells isolated from lung, skin and intestine. Isolated peripheral blood leukocytes were overlayered into endothelial cell monolayer. After washing the unbound cells, adhering lymphocytes were collected with endothelial cells. For quantifying the percentage of the particular cell populations cytofluorometric method was applied. The results are presented as a number of adhering lymphocytes per one endothelial cell. It has been shown that lymphocytes from asthmatic children have significantly greater adhesive potential towards endothelial cell lines from lungs and skin as compared with adhesion to endothelium of intestine origin. However, their B lymphocytes subpopulation demonstrated significantly higher percentage of cells adhering to all endothelial cell lines tested, as compared with B lymphocytes from normal controls. There were not statistically different adhesion efficiencies of T lymphocytes and NK cells. These findings indicate that local, tissue specific adhesive leukocyte-endothelial interactions may be of some importance in pathogenesis of allergic diseases.

Aberrant glycosylation is a common phenomenon accompanying colon carcinoma progression. The changes observed include increased expression of Lewis blood group family antigens, particularly Lex, sialyl Lex and sialyl Lexa. Recently it was shown that these antigenic epitopes may play an important role in cell-cell homotypic as well as heterotypic adhesive interactions. This work presents a phenotypic characteristic of 11 human colon carcinoma cell lines of different degree of differentiation. Expression of potential ligands for endogenous cellular lectins: Lewis antigens, CEA and CD44v6 antigens was evaluated by cytofluorimetry. The aim of the work is to select adhesive and invasive colon carcinoma cells with specified cell surface antigen pattern, for studies on adhesive interactions with endothelial cells, occurring during early steps of metastasis.