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Copyright of Pediatric Endocrinology, Diabetes & Metabolism is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hypophosphatemic rickets are a heterogenic group of diseases, caused by phosphate metabolism disorders. The most widespread and the best known type is the X- linked hypophosphatemia (XLH). Its initial clinical symptoms usually appear in the first two years of the patient's life. Predominant manifestations include deformation of, usually lower, extremities, growth disturbances, distorted body proportions (short limbs), and teeth abnormalities (dental abscesses, decreased mineralization of dentin). Patients affected by XLH exhibit hypophosphatemia, regular calcemia, a normal or low level of 1.25(OH)2D3. Other types of rickets are less frequent; these include autosomal dominant hypophosphatemic rickets (ADHR), autosomal recessive hypophosphatemic rickets (ARHR), paraneoplastic syndrome and rickets connected to McCune-Albright syndrome. The present article discusses the case of a 7-year-old girl, currently undergoing endocrinological treatment due to the diagnosed hypophosphatemic rickets. The patient has been treated at Orthopedic Clinic since she was 11 months old, because of varus deformity of legs. Due to the fact that treatment with vitamin D3 supplements proved to be unsuccessful, the child was directed to Endocrinology Clinic when she was 4 years and 3 months old. Following the proper diagnosis and the thorough modification of the treatment, the parameters of calcium-phosphate metabolism enhanced and the rate of growth was moderately improved. Lower limbs have remained severely deformed. The current state of research does not allow for full clinical recovery in patients with diagnosed hypophosphatemic rickets. The therapy is long and requires cooperation from the patient, who has to take medicines multiple times a day and present for control tests several times a year. In spite of the early onset of therapy, deformation of lower limbs and insufficient growth cannot be prevented in every case. It appears that the ready therapeutic regimens fail in treating the disease and may also lead to serious side effects, manifesting as secondary hyperparathyroidism, and nephrocalcinosis; moreover, they fail in alleviating limb deformations and growth disturbances. [ABSTRACT FROM AUTHOR]

Copyright of Pediatric Endocrinology / Endokrynologia Pediatryczna is the property of Proqurat Andrzej Prokurat and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pediatric Endocrinology / Endokrynologia Pediatryczna is the property of Proqurat Andrzej Prokurat and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Graves' disease (MGB) is the most common cause of hyperthyroidism in children and adolescents. This condition is more common in girls than boys, in a ratio of about 5:1. The coexistence of Graves' disease (MGB) with growth hormone deficiency (GHD) is not common. Much more often GHD connects with hypothyroidism., Case Report: We present the case of 13-year old female patient with Graves' disease, diagnosed at 10 years of age and growth hormone deficiency, which was confirmed at the age of 12. Currently, the girl was qualified to growth hormone therapy., Conclusions: 1) Described by our case is interesting because of the rarity of coexistence Graves' disease with growth hormone deficiency. 2) GH deficiency often accompanies hypothyroidism. Note, however, that hyperthyroidism may be associated with short stature in the course of growth hormone deficiency. 3) The coexistence of endocrine disorders in childhood is not uncommon, so the diagnosis of one disease entity should not exclude further observation for the presence of other endocrine disorders., (© Polish Society for Pediatric Endocrinology and Diabetology.)