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In 28 patients with alcohol dependence syndrome (ADS) the study of selected immunological parameters (percentage of peripheral blood lymphocytes CD3+, CD4+, CD8+, CD19+; lymphocyte transformation without and with phytohemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM); chemiluminescence of peripheral blood granulocytes stimulated with phorbol myristate acetate (PMA)) and Instytut Mérieux' skin tests (Multitest CMI) were performed. The results of immunological parameters were connected with activity of liver enzymes (aspartate aminotransferase (ASP), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT). The differences of reactivity of immune system in the tested groups of patients were observed.

The aim of this study was evaluation of selected immune humoral indicators in connection with biochemical parameters of blood in 28 alcohol dependent men. Increased activity of liver enzymes: AspAT in 53,6% of patients, A1AT in 46,4%, GGTP in 25% were found. Macrocytosis in 29% of patients was observed. There were also abnormal changes of immune proteins concentration: IgM, IgG, IgA, C3, C4 respectively in 60,7%, 46,4%, 21,4%, 42,9%, 10,7% of patients. In the group of patients with normal values of AspAT, GGTP, MCV; abnormal levels of humoral indicators concentration were observed. The correlation between immune proteins concentration and biochemical parameters was not found. The authors conclude that changes of determined immunological parameters may be used as prognostic indicators in disturbances in the alcoholics' immunity system.