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Introduction: Aspergillosis is included in most often appearing mycotic infections of the respiratory system of birds. All species of poultry, ornamental bird and wild can be ill - particularly birds of prey kept in the captivity. Aim of study: Establishing the sensitivity of various species of the Aspergillus genus get from the poultry flocks to readily available drugs, as well as the attempt to determine their profiles of the resistance. Material and methods: Examinations included fungal isolates from the Aspergillus genus get from hens, turkeys, geese and ducks with clinical symptoms of aspergillosis about the diversified intensity. Aspergillus species sensitivity to antifungal drugs were determinate with Sabouraud glucose agar with disc diffusion method in the own modification. Results: We demonstrated, that irrespective of fungus species, the Aspergillus genus is marked by a high sensitivity on enilconazole and terbinafine and with resistance on 5-fluorocytosine, fluconazole, itraconazole and amphotericin B. Antifungal activity of remaining drugs, i.e. ketoconazole, miconazole, clotrimazole, pimaricin and tioconazole, are diversified and seem to depend on the Aspergillus species. Conclusions: An in vitro high antifungal drug resistance is characterizing Aspergillus species isolated from birds which the level seems to depend to some extent on species of the fungus. [ABSTRACT FROM AUTHOR]