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Food intake involves different levels of concomitant exposure to agrotoxic pesticides. Their ingestion, although in low amount, but extended to a long period, may contribute to liver, kidney and thyroid disfunction. These disturbances present a wide populational distribution, thus this study aimed to evaluate the organophosphorus Malathion (MLT) 500 EC® influence upon rats liver, kidney and thyroid functions. Four groups of female 60 days Wistar rats were given MLT 10, 50 and 100 mg/Kg and control animals were given saline solution 0,1 mL/100 g. All administrations occurred per os once daily for 21 days. Twenty four hours after the last administration, blood samples were collected and liver, kidney and thyroid biochemical parameters were analysed. Results showed significant liver transaminase enzymes elevation afeter 50 and 100 mg/Kg of MLT exposure. There was no significant elevation of urea and creatinine and a slight increase of T3 and T4 levels was observed, though it did not reach statistical relevance. However, significant decrease of TSH levels were observed for after exposition to all doses of MLT, which suggests direct hypophysis toxicity, as T3 and T4 levels were not significantly altered. These results emphasize the concern about chronic agrotoxic exposure, which can occur in a lifetime cumulative pattern by food intake containing pesticide remnants and be related to multiple organs disfunction. Possibly, different doses and time of exposure might result in different outcomes and evidence more influences upon thyroid hormones secretion caused by MLT. [ABSTRACT FROM AUTHOR]