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4 results on '"ANTIMICROBIAL ACTIVITIES"'

1. Síntese e avaliação da atividade antimicrobiana de novas 4-tiazolidinonas obtidas a partir de formilpiridina tiossemicarbazonas Synthesis and antimicrobial activities of new 4-thiazolidones derived from formipyridine thiosemicarbazones

Author

George Leonardo Verçoza, Danniel Delmondes Feitoza, Antônio José Alves, Thiago Mendonça de Aquino, José Gildo de Lima, Janete Magali Araújo, Ivana Gláucia B. Cunha, and Alexandre José da Silva Góes

Subjects
4-thiazolidinones, formilpyridine thiosemicarbazones, antimicrobial activities, Chemistry, QD1-999
Abstract

Twelve novel 4-thiazolidinone derivatives (2a-l) have been synthesized by reacting formilpyridine thiosemicarbazones (1a-l) and anhydride maleic in toluene. Their chemical structures were confirmed by IR, ¹H and 13C NMR. The new compounds were submitted to in vitro evaluation against pathogenic Gram-positive, Gram-negative bacteria and yeasts. The findings obtained showed that the compounds 2a, 2d, 2e and 2g were effective against some of the bacterial strains used, whereas the compounds 2d, 2e and 2i exhibited a moderate antifungal activity against the yeast strains evaluated. An initial structure activity relationship (SAR) was established.

Published
2009
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2. Constituintes químicos e atividade antimicrobiana dos extratos de Dilodendron bipinnatum (sapindaceae) Chemical constituents and antimicrobial activity of extracts from Dilodendron bipinnatum (sapindaceae)

Author

Josiane Cristina dos Santos, Carlos Alberto Nastally de Oliveira, Larissa Varella, Andréia Pereira Matos, Ana Paula Terezan, Ana Cristina Leite, João Batista Fernandes, Paulo Cezar Vieira, Maria Fátima das Graças Fernandes da Silva, and José Rubens Pirani

Subjects
Sapindaceae, Dilodendron bipinnatum, antimicrobial activities, Chemistry, QD1-999
Abstract

The phytochemical investigation of ethanolic extracts from leaves, branches and stems of D. bipinnatum afforded the steroids β-sitosterol, stigmasterol, campesterol, sitostenone and sitosterol-3-O-β-D-glycopyranoside, along with two cycloartane triterpenes: cycloeucalenol and 24-methylenecycloartenol. The antimicrobial activity of the extracts was evaluated against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), Micrococcus luteus (ATCC 9341) and Candida albicans (ATCC 10231). The extracts of the leaves and branches showed moderate activity against Candida albicans. The extract of the branches was active against Micrococcus luteus. This is the first report on the phytochemical study of D. bipinnatum.

Published
2010
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3. Obtenção de derivados químicos de produtos naturais empregando catálise convencional e enzimática

Author

Silva, Maria de Lourdes e and David, Jorge Mauricio

Subjects
Artemia salina lethality, Lamiaceae, Eriope blanchetii, Atividades antimicrobiana, Antimicrobial activities, Letalidade Artemia salina, Triterpenes derivatives, Derivados triterpenos
Abstract

202 f. Submitted by Ana Hilda Fonseca (anahilda@ufba.br) on 2013-03-27T15:07:41Z No. of bitstreams: 1 Tese Maria de Lourdes Completa.pdf: 1276547 bytes, checksum: ab45e41c0f73a5e85be2b1a246cbdb9e (MD5) Approved for entry into archive by Ana Hilda Fonseca(anahilda@ufba.br) on 2013-06-05T16:01:37Z (GMT) No. of bitstreams: 1 Tese Maria de Lourdes Completa.pdf: 1276547 bytes, checksum: ab45e41c0f73a5e85be2b1a246cbdb9e (MD5) Made available in DSpace on 2013-06-05T16:01:37Z (GMT). No. of bitstreams: 1 Tese Maria de Lourdes Completa.pdf: 1276547 bytes, checksum: ab45e41c0f73a5e85be2b1a246cbdb9e (MD5) Previous issue date: 2012 Os triterpenos são extensamente distribuídos na natureza, principalmente no reino vegetal, pois se acredita que uma de suas funções fisiológicas nos vegetais seja de defesa química contra patógenos e herbívora. Podem ser encontrados na forma livre, como glicosídeos ou ainda derivados esterificados. Os ácidos oleanólico, betulínico e ursólico são os triterpenos ácidos mais comuns de ocorrência em vegetais e, possuem atividades antitumorais conhecidas. Este trabalho descreve um levantamento da ocorrência dessas substâncias e obtenção de derivados a partir deles e de ácidos graxos comuns. Os ácidos betulínico, ursólico e oleanólico, isolados das partes aéreas de Eriope blanchetii (Lamiaceae), foram submetidos a diferentes reações de esterificação obtendo-se assim 12 derivados esterificados na posição C-3. Tanto as substâncias isoladas quanto os derivados triterpênicos foram caracterizados por técnicas espectroscópicas no IV, RMN de 1H e 13C. Os derivados foram submetidos a testes de atividade antioxidante, letalidade frente Artemia salina e atividade antimicrobiana. Além disso, o ácido o-metoxicinâmico e ácido oleico foram submetidos a esterificação com etanol e metanol empregando-se Novoenzyme, comparando-se o rendimento do produto da reação a temperatura ambiente e sob irradiação de microondas Salvador

Published
2012

4. Síntese e avaliação da atividade antimicrobiana de novas 4-tiazolidinonas obtidas a partir de formilpiridina tiossemicarbazonas

Author

Ivana Glaucia Barroso Cunha, Alexandre José da Silva Góes, Thiago Mendonça de Aquino, José G. de Lima, Danniel Delmondes Feitoza, George Leonardo Verçoza, Janete Magali de Araújo, and Antonio J. Alves

Subjects
Gram-negative bacteria, biology, 4-thiazolidinones, Stereochemistry, Chemical structure, Gram-positive bacteria, General Chemistry, Carbon-13 NMR, biology.organism_classification, In vitro, Yeast, formilpyridine thiosemicarbazones, Structure–activity relationship, antimicrobial activities, Bacteria
Abstract

Twelve novel 4-thiazolidinone derivatives (2a-l) have been synthesized by reacting formilpyridine thiosemicarbazones (1a-l) and anhydride maleic in toluene. Their chemical structures were confirmed by IR, 1H and 13C NMR. The new compounds were submitted to in vitro evaluation against pathogenic Gram-positive, Gram-negative bacteria and yeasts. The findings obtained showed that the compounds 2a, 2d, 2e and 2g were effective against some of the bacterial strains used, whereas the compounds 2d, 2e and 2i exhibited a moderate antifungal activity against the yeast strains evaluated. An initial structure activity relationship (SAR) was established.

Published
2009

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