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Orientador: Edson Antunes Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas Resumo: O declínio hormonal na mulher leva à chamada síndrome geniturinária na menopausa (SGM), que compreende, entre outros fatores, de sintomas do trato urinário inferior (STUI) como aumento da frequência miccional, urgência, noctúria e incontinência urinária, os quais impactam negativamente a qualidade de vida e interação social da pessoa. A terapia de reposição hormonal com testosterona vem sendo utilizada em mulheres pós-menopausadas para aliviar certos sintomas da deficiência androgênica como perda da libido, da massa osteomuscular e da função cognitiva. Entretanto, poucos estudos têm se voltado à compreensão dos efeitos desta reposição androgênica na disfunção miccional na pós-menopausa. Estudo prévio do nosso grupo avaliou os efeitos da reposição com testosterona na disfunção miccional de ratas, após 4 meses de ovariectomia (OVX)... O resumo poderá ser visualizado no texto completo da tese digital Abstract: The hormonal decline in women leads to the so-called genitourinary syndrome on menopause (GSM), that include, among other factors, the lower urinary tract symptoms (LUTS) such us increment of urinary frequency, urgency, noctúria and urinary incontinence, affecting negatively the quality of life and social interaction of the person. The hormonal replacement with testosterone has been used in postmenopausal women to relieve certain symptoms of the androgenic deficiency as loss of libido, musculoskeletal mass and cognitive function. However, few studies have focused to understanding of effects of androgenic replacement on voiding dysfunction. A previous study of our group evaluated the effects of testosterone replacement on voiding dysfunction in rats after 4 months of ovariectomy (OVX). Hormonal reduction causes in vivo voiding changes (increment of frequency and the basal, threshold and post- voiding pressures), as well as bladder hypocontractility and urethral hypercontractility in vitro which were reverted by androgen in supraphysiological doses. These protective effects of testosterone were independent of estrogen synthesis, because they remained even after treatment with letrozol (inhibitor of aromatization of testosterone). However, we still do not know the mechanism of action of androgens on the smooth muscle of lower urinary tract (bladder and urethra) under physiological and pathological condition (OVX)... The abstract is available with the full electronic document Doutorado Farmacologia Doutora em Farmacologia FAPESP 2017/26564-9 CNPQ 146942/2016-7 CAPES 001