8 results on '"D'Angelo L"'
Search Results
2. O G-CSF na terapia do acidente vascular cerebral
- Author
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Maset, Angelo L., Piron-Ruiz, Lilian, Greco, Oswaldo T., Lago, Mario, Poloni, Alana F. C., and Ruiz, Milton A.
- Subjects
isquemia cerebral ,AVC isquêmico ,neuroproteção ,neuroprotection ,isquemia ,ischemia ,G-CSF ,brain ischemia - Abstract
O fator estimulador de colônias granulocitárias (G-CSF) é uma glicoproteína descrita há mais de vinte anos, e é largamente utilizada para tratamento de estados neutropênicos e no transplante de medula óssea. O G-CSF estimula células-tronco hematopoéticas e regula crucialmente a sobrevivência de neutrófilos maduros, pós-mitóticos, através da inibição da apoptose. Além do efeito sistêmico, mais recentemente tem-se demonstrado uma surpreendente atividade do G-CSF no sistema nervoso central. A administração de G-CSF mobiliza células-tronco e progenitoras da medula óssea para o sangue periférico, que, por sua vez, atravessa a barreira hemato-encefálica (BHE) e se dirige à área acometida do cérebro. A atividade do G-CSF no sistema nervoso central tem sido caracterizada como multimodal, pois, além do efeito mobilizador de células da medula óssea, demonstrou uma ação direta neuroprotetora através de diferentes mecanismos, tais como a atividade antiapoptótica em neurônios, regeneração da vascularização, efeito anti-inflamatório e estimulação da neurogênese endógena. Este relato sumariza a ação do G-CSF no sistema nervoso central e aborda seu potencial para o emprego no acidente vascular cerebral. The granulocyte colony-stimulating-factor (G-CSF) is a glycoproteina which has been described for decades, and it is commonly utilized in the treatment of neutropenic states and bone marrow transplants. G-CSF stimulates hematopoietic stem-cels e crucially regulates the survival of mature neutrophils through a mechanism of apoptosis inhibition. Beyond its systemic effect, recently it has been shown its surprising activity in the central nervous system (CNS). G-CSF administration mobilizes bone marrow stem cells para systemic blood, and those cells cross the blood-brain-barrier e target brain's damaged area. G-CSF's activity in the CNS has been defined as multimodal, because additionally it has been demonstrated a direct neuroprotective action through different mechanisms such as antiapoptotic activity, angiogenesis, anti-inflamatory effect, and stimulation of endogenous neurogenesis. This paper sumarizes G-CSF action in the CNS and approaches its potential para use in stroke.
- Published
- 2009
3. Occurrence of Migdolus fryanus (Coleoptera: Cerambycidae) in Pinus caribaea hondurensis plantations
- Author
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Angelo L. T. Ottati, Carlos Frederico Wilcken, Cassiano Orlato, and Universidade Estadual Paulista (Unesp)
- Subjects
Forest pest ,Insecta ,business.industry ,Praga florestal ,root pest ,Pest control ,Forestry ,tropical pine ,Biology ,praga de raiz ,business ,pinheiro - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:49:45Z No. of bitstreams: 1 S0100-67622005000100018.pdf: 343069 bytes, checksum: e65dc0a2006fa049f6a9a1801a558ffe (MD5) Made available in DSpace on 2013-08-22T18:49:45Z (GMT). No. of bitstreams: 1 S0100-67622005000100018.pdf: 343069 bytes, checksum: e65dc0a2006fa049f6a9a1801a558ffe (MD5) Previous issue date: 2005-02-01 Made available in DSpace on 2013-09-30T17:47:04Z (GMT). No. of bitstreams: 2 S0100-67622005000100018.pdf: 343069 bytes, checksum: e65dc0a2006fa049f6a9a1801a558ffe (MD5) S0100-67622005000100018.pdf.txt: 9319 bytes, checksum: 8c4ec73244e1e2d37b27668ad0ae76bd (MD5) Previous issue date: 2005-02-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:20:50Z No. of bitstreams: 2 S0100-67622005000100018.pdf: 343069 bytes, checksum: e65dc0a2006fa049f6a9a1801a558ffe (MD5) S0100-67622005000100018.pdf.txt: 9319 bytes, checksum: 8c4ec73244e1e2d37b27668ad0ae76bd (MD5) Made available in DSpace on 2014-05-20T13:20:50Z (GMT). No. of bitstreams: 2 S0100-67622005000100018.pdf: 343069 bytes, checksum: e65dc0a2006fa049f6a9a1801a558ffe (MD5) S0100-67622005000100018.pdf.txt: 9319 bytes, checksum: 8c4ec73244e1e2d37b27668ad0ae76bd (MD5) Previous issue date: 2005-02-01 Larvas de Migdolus fryanus Westwood (Coleoptera: Cerambycidae) foram encontradas danificando raízes de mudas de P. caribaea var. hondurensis (Sénéel) Barr. & Golf. no Estado de São Paulo. Isso aumenta a importância dessa espécie, cujos danos, em espécies florestais, têm aumentado, principalmente, em plantios de eucalipto. Esse é o primeiro registro de M. fryanus em plantios de Pinus, e o referido inseto pode ser considerado uma nova praga dessa espécie florestal. Detalhes das características morfológicas e biológicas, danos e possíveis métodos de controle de M. fryanus são discutidos. Larvae of Migdolus fryanus Westwood (Coleoptera: Cerambycidae) were found damaging roots of young plants of P. caribaea hondurensis (Sénéel) Barr. & Golf. in the State of São Paulo, Brazil. This fact increases the importance of this species because the damages have been increasing in forest species specially in eucalyptus plantations. This is the first record of M. fryanus in pine plantations and this insect can be considered a pest of pine plants. Details on the morphology and biological characteristics, damage and possible control methods to M. fryanus are discussed. UNESP FCA Departamento de Produção Vegetal UNESP FCA Departamento de Produção Vegetal
- Published
- 2005
4. Tetanorhynchus leonardosi (Mello-Leitão) (Orthoptera: Proscopiidae), a new eucalyptus pest
- Author
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Angelo L. T. Ottati, Carlos Alberto Hector Flechtmann, and Universidade Estadual Paulista (Unesp)
- Subjects
Walking stick ,Insecta ,biology ,Orthoptera ,fungi ,food and beverages ,Vegetation ,biology.organism_classification ,Eucalyptus ,chemistry.chemical_compound ,Horticulture ,chemistry ,Parathion methyl ,Host plants ,dispersion ,Upper third ,PEST analysis ,damage ,walking stick - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:02:21Z No. of bitstreams: 1 S0301-80591997000300027.pdf: 31811 bytes, checksum: 7675dd56820edb800166935ef5da32fd (MD5) Made available in DSpace on 2013-08-22T19:02:21Z (GMT). No. of bitstreams: 1 S0301-80591997000300027.pdf: 31811 bytes, checksum: 7675dd56820edb800166935ef5da32fd (MD5) Previous issue date: 1997-12-01 Made available in DSpace on 2013-09-30T20:03:15Z (GMT). No. of bitstreams: 2 S0301-80591997000300027.pdf: 31811 bytes, checksum: 7675dd56820edb800166935ef5da32fd (MD5) S0301-80591997000300027.pdf.txt: 15297 bytes, checksum: e93f7a20489f0537e286170bf08aa9b7 (MD5) Previous issue date: 1997-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:16:12Z No. of bitstreams: 2 S0301-80591997000300027.pdf: 31811 bytes, checksum: 7675dd56820edb800166935ef5da32fd (MD5) S0301-80591997000300027.pdf.txt: 15297 bytes, checksum: e93f7a20489f0537e286170bf08aa9b7 (MD5) Made available in DSpace on 2014-05-20T15:16:12Z (GMT). No. of bitstreams: 2 S0301-80591997000300027.pdf: 31811 bytes, checksum: 7675dd56820edb800166935ef5da32fd (MD5) S0301-80591997000300027.pdf.txt: 15297 bytes, checksum: e93f7a20489f0537e286170bf08aa9b7 (MD5) Previous issue date: 1997-12-01 We report for the first time the attack of the walking stick Tetanorhynchus leonardosi (Mello-Leitão) (Orthoptera: Proscopiidae) on young eucalyptus, Eucalyptus urophylla, in Brazil. The upper third of the trees was attacked (apical meristems and new leaves). During the hottest hours of the day the insects were found sheltered between leaves on the median third of the plants, and feeding when temperatures were milder. The attack was heterogeneous in the stand, being more concentrated when it was neighbouring an area of native 'Cerrado' vegetation. Mean defoliation was 5.8%, with an average of 5.2% of plants with apical meristems cut by the walking sticks. An application of Methyl Parathion was not effective against the pest. Apparently plants older than 6 months were less attacked by the insects, that preferred 3-month old trees. The reduction of native vegetation may explain the dispersion of T. leonardosi from its native host plants to the exotic eucalyptus. UNESP UNESP Departamento de Biologia UNESP UNESP Departamento de Biologia
- Published
- 1997
5. Scolytidae em Área de Mata Nativa de Cerrado em Selvíria, MS, Brasil
- Author
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Angelo L. T. Ottati and Carlos Alberto Hector Flechtmann
- Published
- 1996
- Full Text
- View/download PDF
6. [New clinical aspects of cardiac myxomas: a clinical and pathological reappraisal].
- Author
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Bordalo AD, Alves I, Nobre AL, Silva F, Lemos A, Serpa C, Fernandes A, and Cravino J
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Heart Neoplasms pathology, Humans, Male, Middle Aged, Myxoma pathology, Retrospective Studies, Young Adult, Heart Neoplasms diagnosis, Myxoma diagnosis
- Abstract
Unlabelled: Easy access to echocardiography and its extensive and repeated use (as is the case in Portugal) now facilitates the early diagnosis of cardiac myxoma (CM)., Objective: To re-evaluate the clinical and pathological profile of CM under current diagnostic conditions., Methods: We performed a retrospective study of 40 patients consecutively referred for surgery (between January 2003 and January 2010) with a histologically-confirmed diagnosis of CM - 26 female (F) and 14 male (M), with a mean age of 64±12 years (range 12-81; 53% over 65, 43% over 70); 39 patients were operated (one was not operable due to major neurological deficit). Clinical characteristics, surgical protocols, follow-up records of survivors (range 1-76 months, with serial echocardiograms), and histological data were reviewed., Results: The apparent incidence was 2.6 cases/million/year; the overall F/M ratio was 1.9:1 (1.3:1 in those aged over 65, similar to the general population). The CM was located in the left atrium (LA) in 92.5%, with insertion in the fossa ovalis of the interatrial septum (IAS) in 53% (only 57% of LA myxomas), and outside the IAS in 30%. The mean size was 4.6 x 3.7cm. Asymptomatic tumors occurred in 48% of the total population (sessile and/or atypically inserted in 74%; 63% of large size, over 3 x 3cm), 61% were in patients referred in the last 25 months of the study; 23% of patients showed constitutional symptoms (all with very large CMs - mean 6.7 x 5.1cm), 35% had hemodynamic/obstructive symptoms, and 15% presented with embolic events. There was evidence of CM-related mitral valve (MV) disease in 20% of patients, resulting in moderate to severe mitral regurgitation requiring associated MV surgery in 13%. Significant comorbidities were present in 69%. Surgical procedures included simple excision in 74%; septoplasty/atrioplasty associated with extensive resection of the insertion site in 26%; and combined surgery (CM excision plus other procedures) in 28%. There were significant postoperative complications in 38%. In-hospital mortality was 10%; postoperative mortality was 7.7%. Mean follow-up was 30 months (100% of survivors, 44% for >2 years); late mortality was 5.6% and no CM recurrences were observed., Conclusions: (1) CM has a higher incidence than described in the literature and mainly affects patients aged over 65; the reported predominance of female patients disappears after the age of 65. (2) Most CM cases are now asymptomatic at presentation as a result of earlier diagnosis. (3) CM is the cause of MV disease requiring surgical correction in more than 10% of cases, and is associated with significant postoperative mortality, mainly due to the presence of comorbidities., (Copyright © 2011 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
7. [Control of postoperative hemorrhage in isolated coronary bypass surgery: comparison of tranexamic acid effects in off-pump surgery with aprotinin effects in conventional surgery].
- Author
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Bordalo AD, Nobre AL, Silva F, Serpa C, and Cravino J
- Subjects
- Aged, Coronary Artery Bypass, Off-Pump, Female, Humans, Male, Middle Aged, Retrospective Studies, Aprotinin therapeutic use, Coronary Artery Bypass, Hemostatics therapeutic use, Postoperative Hemorrhage prevention & control, Tranexamic Acid therapeutic use
- Abstract
Unlabelled: In spite of the strong criticism elicited thereafter, the results of a multicentric study on the consequences of several perioperative anti-hemorrhagic strategies in cardiac surgery, published five years ago, led to the aprotinin (Aprot) withdrawal from the market and its progressive replacement by tranexamic acid (TrAc) in many surgical departments., Objective: To evaluate the hemostatic effects and clinical consequences of TrAc use or non-use in off-pump coronary bypass surgery (CABG) and compare them with those of Aprot use or non-use in conventional (conv) CABG., Material and Methods: Retrospective analysis of 2 groups (Gr) of patients (pts): GrA - 252 pts undergoing isolated conv CABG (GrA1 - 185 pts submitted to an intra-operative full-dose Aprot protocol; GrA2 - 67 pts operated without Aprot); GrB - 383 pts undergoing isolated off-pump CABG (GrB1 - 136 pts submitted to an intra-operative low-dose TrAc protocol; GrB2 - 247 pts operated in absence of TrAc). Pre-operative clinical characteristics (GrA1 vs GrA2, GrB1 vs GrB2): mean age (years) - 65 vs 64 (NS), 64 vs 64; female gender - 20% vs 21% (NS), 23% vs 20% (NS); logistic Euroscore - 5.1% vs 6.2% (NS), 6.3% vs 5.5% (NS); chronic renal failure - 21% vs 27% (NS), 27% vs 25% (NS); diffuse coronary artery disease - 34% vs 42% (NS), 36% vs 30% (NS); pre-operative betablocker treatment - 64% vs 55% (NS), 74% vs 71% (NS); statin therapy for > 3 months - 78% vs 82% (NS), 81% vs 85% (NS). Pts have been operated by 4 surgeons largely experienced in both CABG modalities. Antiplatelet therapy was stopped => 4 days prior to surgery (but aspirin was maintained in high-risk pts). Results (GrA1 vs GrA2, GrB1 vs GrB2): 1) Bleeding (mL/pt - mean): 783 vs 1375 (p < 0.001), 1061 vs 1368 (p < 0.001); blood loss > 1500 mL (%pts) - 5.4% vs 34% (p < 0.0001), 12% vs 28% (p < 0.001); surgical re-exploration for bleeding - 1.1% vs 3.0% (NS), 2.2% vs 2.0% (NS). 2) Transfusion of blood products (U/pt - mean): plasma - 0.56 vs 2.19 (p < 0.001), 1.45 vs 1.03 (p < 0.05); platelets - 0.09 vs 0.22 (p < 0.02), 0.24 vs 0.15 (NS). 3) Renal function (%pts): increased serum cre- atinine - 56% vs 56%, 55% vs 38% (p < 0.001); hemofiltration use - 1.1% vs 1.5% (NS), 1.5% vs 0.4% (NS). 4) Perioperative myocardial infarction - 21.6% vs 17.9% (NS), 17.6% vs 14.6% (NS); other ischemic events - 3.2% vs 3.0% (NS), 1.5% vs 1.2% (NS). 5) Hospital mortality: 4.8% vs 4.5% (NS), 4.4% vs 1.6% (NS)., Conclusions: 1) TrAc does not reduce the risk of surgical re-exploration for bleeding. 2) Taking into account the differences between conv CABG and off-pump CABG, TrAc hemostatic effect seems to be inferior to that of Aprot, without offering a better safety profile in terms of lesser renal or ischemic risk as a counterpart.
- Published
- 2011
8. Revision of the Sokolow-Lyon-Rappaport and cornell voltage criteria for left ventricular hypertrophy.
- Author
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Rodrigues SL, D'Angelo L, Pereira AC, Krieger JE, and Mill JG
- Subjects
- Adult, Aged, Female, Humans, Hypertrophy, Left Ventricular etiology, Male, Middle Aged, ROC Curve, Risk Factors, Sensitivity and Specificity, Sex Characteristics, Echocardiography methods, Electrocardiography methods, Hypertrophy, Left Ventricular diagnosis
- Abstract
Background: Electrocardiographically-detected left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular morbidity and mortality., Objective: To assess the performance of the Sokolow-Lyon-Rappaport (SLR) and Cornell voltage criteria in a population sample regarding the diagnosis of LVH on echocardiogram (ECHO)., Methods: A total of 641 out of the 682 participants of the second phase of the MONICA-Vitória project were assessed using electrocardiogram and echocardiogram. A subgroup of healthy individuals (n=269) was used to generate reference values of LV mass (LVM). Sensitivities and specificities of the electrocardiographic criteria were determined by the ROC (receptor-operator characteristics) curve in relation to the diagnosis of LVH, as defined by the internal echocardiographic criterion (LVM > 48 and 46 g/m2.7 for males and females, respectively)., Results: The prevalence of LVH as detected by ECHO was 23.7% in the total sample, in which 49% of the individuals were hypertensive. The Cornell criterion showed a better association with the LVM as estimated by ECHO (r= 0.37, p < 0.01) than the SLR criterion (r= 0.19) as well as a better performance in the analysis of the area under the ROC curve. The new cut-off points for the internally-defined Cornell voltage criterion (2.3 mV for males and 1.9 mV for females) showed an acceptable combination of sensitivity (22.5 and 28% for males and females, respectively), with a high specificity (95%)., Conclusion: The classic SLR and Cornell voltage criteria showed a low performance in relation to LVH as detected by the ECHO. However, this accuracy may be improved by using the Cornell voltage criteria defined in the present study.
- Published
- 2008
- Full Text
- View/download PDF
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