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Objective: This study aimed to determine if personality disorder (PD) predicted functional outcomes in patients with major depressive disorder (MDD). Methods: Data (n=71) from a double-blind, randomized, placebo-controlled 12-week trial assessing the efficacy of 200 mg/day adjunctive minocycline for MDD were examined. PD was measured using the Standardized Assessment of Personality Abbreviated Scale. Outcome measures included Clinical Global Impression – Improvement (CGI-I), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social and Occupational Functioning Scale (SOFAS), and Range of Impaired Functioning (RIFT). Analysis of covariance was used to examine the impact of PD (dichotomized factor [≥ 3] or continuous measure) on the outcome measures-treatment group correlation. Results: PD was identified in 69% of the sample. After adjusting for age, sex, and baseline scores for each of the outcome measures, there was no significant difference between participants with and without PD on week 12 scores for any of the outcome measures (all p > 0.14). Conclusion: In this secondary analysis of a primary efficacy study, PD was a common comorbidity among those with MDD, but was not a significant predictor of functional outcomes. This study adds to the limited literature on PD in randomized controlled trials for MDD. Clinical trial registration: ACTRN12612000283875.

Abstract Sarcoptic mange or scabies is a contagious parasitic skin disease that affects a wide range of domestic and wildlife species. A cross-sectional study was carried out to determine the prevalence, molecular identification, and characteristics of sarcoptic mange in vicuñas. A total of 3,274 vicuñas were examined. Following ritual harvesting events (“chaccus”) in 13 Andean communities. The presence of mange mites was determined by the skin scraping technique and confirmed by PCR analysis using specific primers for the ITS2 gene of Sarcoptes scabiei. The presence of mange mites was also confirmed by microscopy using samples taken from wallows. A data collection form was used to register the characteristics of the vicuñas sampled. The prevalence of sarcoptic mange was 4.9% (95% CI: 4.1 - 5.6%). All samples from wallows tested positive (9/9). Importantly, the presence of the species S. scabiei was molecularly confirmed. Adult females with regular body condition were more susceptible to sarcoptic mange, although the lesions were mild. This study confirms the presence of S. scabiei in semi-captive vicuñas and points to the possible role of wallows in the dissemination of Sarcoptes mites.

El estudio optimiza el logro de rendimiento académico mediante las variables: grado escolar, el tipo de recreo y el tiempo de interrupción de clases. Mediante un método cuantitativo, longitudinal, experimental y superficial de respuesta de diseño compuesto central en orden de 26 corridas, con puntos axiales y centrales (-1,0,1). Sus resultados indican valores óptimos de logro de rendimiento académico (92,8%) cuando aplica recreos de mente plena con parámetros de interrupciones cada 44.84 minutos en los grados de estudio segundo y tercero de secundaria (2.81). Concluye que el recreo activo de mente plena getra mejor rendimiento académico que el lúdico.

Este estudo teve o objetivo de identificar a influência da pandemia de covid-19 nas séries temporais da mortalidade materna no Recife, Pernambuco, no período de 2018-2021. Trata-se de um estudo ecológico com dados do Sistema de Informações sobre Mortalidade e do Sistema de Informações sobre Nascidos Vivos, para o cálculo das razões de mortalidade materna. Calculou-se a razão da mortalidade materna dividindo o número de óbitos maternos pelos nascidos vivos por mês e utilizou-se da técnica de regressão Zero Adjusted Inverse Gaussian, para análise do dado. Foram registrados 61 óbitos maternos, 21 nos dois anos antes da pandemia e 40 óbitos nos dois primeiros anos pandêmicos. As mulheres negras foram a maior parte, com idade média de 33 anos e desvio padrão de 8,4 anos. No período anterior à pandemia, as hemorragias apresentavam destaque. Nos dois primeiros anos pandêmicos a infecção por coronavírus representou a principal causa básica de óbito materno. Os resultados do modelo de regressão demonstraram que houve aumento, estatisticamente significante, na razão da mortalidade materna no período pandêmico, sendo o aumento do primeiro semestre de 2020, cuja razão foi de 182,83 por 100.000 nascidos vivos. A pandemia de covid-19 influenciou no aumento da razão da mortalidade materna e contribuiu para mudanças epidemiológicas nas causas de óbito materno no Recife. PALAVRAS-CHAVE: Mortalidade materna. Covid-19. Nascidos vivos.

A partir de la tendencia jurídica global del reconocimiento de la naturaleza como una entidad titular de derechos, este artículo propone, en primer lugar, abordar la debida diligencia empresarial en derechos humanos con un enfoque holístico, de modo que el núcleo de la responsabilidad de las empresas de respetar los derechos humanos incluya, además de la emergente debida diligencia climática, los derechos de la naturaleza. Este enfoque holístico se fundamenta en la adopción por parte de distintos ordenamientos jurídicos nacionales de los derechos de la naturaleza, y en la relación de integralidad reconocida entre los derechos humanos y la naturaleza. En segundo lugar, el artículo propone aplicar esta debida diligencia empresarial a la transición energética, teniendo en cuenta el papel que juegan las empresas en el proceso de transformación del sector energético como estrategia clave para enfrentar el cambio climático. En este sentido, la transición energética implementada bajo los estándares de la debida diligencia en derechos humanos, propuesta en este texto, respondería a la máxima: la transición energética no se trata solo de sustituir fuentes de energía fósil por fuentes renovables, sino que debe estar alineada con el desarrollo sostenible, la protección de la naturaleza y el respeto por los derechos humanos.

Introducción. La glomerulonefritis membranoproliferativa (GnMP) es un patrón de lesión glomerular hipercelular mesangial con adelgazamiento de la membrana basal glomerular y proliferación endocapilar que está mediado por las inmunoglobulinas o el sistema del complemento en el mesangio y endotelio capilar. Objetivo. Evaluar la respuesta a la farmacoterapia en pacientes diagnosticados con GnMP en una clínica de Barranquilla entre los años 2007 y 2014. Materiales y métodos. Estudio de cohorte retrospectivo en el que se evaluaron 58 pacientes con diagnóstico de GnMP por biopsia renal, quienes se clasificaron como respondedores y no respondedores. Se realizó una evaluación de tratamiento estándar según tipo de GnMP: mediado por complemento y mediado por inmunocomplejos e inmunofluorescencia negativa a los 6 y 12 meses de tratamiento. Resultados. La edad promedio de los participantes fue de 35±13 años. De 58 pacientes, 52% eran mujeres, 63% desarrolló enfermedad renal crónica (ERC) al año de evaluación, 25.8% logró remisión (22.4% completa y 3.4% parcial) y 74.2% no logró entrar en remisión. Conclusión. La GnMP es una causa importante de ERC entre la población estudiada. La respuesta al tratamiento inmunosupresor no demostró beneficios estadísticamente significativos, independiente del tipo de GnMP.

Introduction: It is well known that musicians are a group prone to suffer from playing-related musculoskeletal disorders. Professional orchestra musicians play for several hours a week and have to fight against pain caused by their profession. The aim of this study was to explore and describe self-reported complaints among professional orchestra musicians and to compare its intensity and the prevalence between string and wind instruments. Material and Methods: Hundred and twelve professional orchestra musicians from the three main professional orchestras from the North of Portugal were individually interviewed about the prevalence and the intensity (measured by verbal numerical scale for pain) of their playing-related musculoskeletal disorders. Results: About two third (62.5%) of the interviewed musicians presented playing-related musculoskeletal disorders during the time of the interview. Despite there are no significant statistic values between groups, results suggested that playing-related musculoskeletal disorders are more common in string players and more intense in wind players. Discussion: Referring to the prevalence of playing-related musculoskeletal disorders, our data is in line with other studies from different countries. More than half of professional orchestra musicians in the North of Portugal are playing with a mild to moderate pain. Conclusion: Future studies focusing on working-related problems among professional orchestra musicians in Portugal would be useful to better describe the problem of occupational diseases among performing artist.

Esta investigación hace una descripción del sector carbonífero colombiano a partir de su marco jurídico e institucional, describe y analiza cómo opera y se estructura la administración pública que regula, administra y fiscaliza al sector carbonífero y su realidad en términos ambientales, sociales y fiscales. Finalmente, se hace una descripción bajo un enfoque neo-institucional de la política minera en el país, sus fallas, limitaciones y problemas de legitimidad.

Using Star Wars and the Marvel Extended Universe as primary examples, this essay explores the ways that transmedia storytelling practices have altered Hollywood entertainment, resulting in a stronger emphasis on world building and a more participatory relationship with its audiences. Transmedia in its contemporary form assumes a networked audience that is actively seeking out information about entertainment experiences they care about, resulting in much more extensive use of paratexts to signal what we might expect from upcoming releases, more blogs and podcasts that recap and interpret cult media texts, and more informal spaces where people can debate, pool knowledge, share their own grassroots creations, and otherwise participate in the fan phenomenon that grow up around such works.

En el siguiente artículo de reflexión jurídica, se hace referencia al procedimiento administrativo de la revocatoria directa que necesariamente termina con la expedición de un acto administrativo, el cual se encuentra regulado en el código de procedimiento administrativo y de lo contencioso administrativo. Sin embargo, la administración goza de prerrogativas como la autotutela donde se permite que ella misma, al adoptar sus decisiones, las pueda hacer cumplir sin la presencia de un juez, hasta el punto que pueda revocar sus propios actos administrativos. No obstante, a pesar de gozar de tal poder, sus decisiones no son absolutas y, por ende, los particulares o quien se sienta afectado por dicha decisión podrá acudir a la jurisdicción contenciosa administrativa que establecerá la legalidad, o no, del acto administrativo con la posibilidad de desvirtuar las presunciones de que este goza y hacerlo desaparecer del mundo jurídico.

El hombre es un ser que está dentro de la historia y, por tanto, ese es su escenario natural, de tal forma que el reconocimiento, la identidad y la dignidad de la persona humana hoy son de carácter universalmente importante, se es persona por naturaleza y ante el ordenamiento jurídico por sí mismo en razón de su dignidad, no es posible separar la concepción ontológica de lo puramente legal. Respetar al hombre es tratarlo según su dignidad, sin distinción alguna, es aceptar sus diferencias, la búsqueda de la identidad y el reconocimiento dependen en gran parte de la aceptación que uno mismo logre o se forme de sí mismo. De allí la importancia de analizar la obra de Charles Taylor sobre el multiculturalismo y la política del reconocimiento, con el propósito de comprender la vigencia de dicha propuesta en nuestros días, en un contexto en el que impera la exclusión, la violencia, el desconocimiento del otro, no se respetan las cosmovisiones y no se legitima a los grupos minoritarios.

O texto discute a relevância da ficção derivada de obras literárias pelos seus fãs, levantandoa diferença entre a leitura crítica e a leitura criativa. Ele explora as principaistécnicas utilizadas e as motivações dessa subcultura, assim como sua manifestação naInternet. Além de citar algumas obras comerciais baseadas em clássicos, ele tambémdiscute o possível impacto pedagógico de se apropriar desse fenômeno na sala de aula.

Cuban (1986; 2000) has argued that computers are largely incompatible with the requirements of teaching, and that, for the most part, teachers will continue to reject their use as instruments of student work during class. Using data from a nationally representative survey of 4th through 12th grade teachers, this paper demonstrates that although Cuban correctly characterizes frequent use of computers in academic subject classes as a teaching practice of a small and distinct minority, certain conditions make a big difference in the likelihood of a teacher having her students use computers frequently during class time. In particular, academic subject-matter teachers who have at least five computers present in their classroom, who have at least average levels of technical expertise in their use, and who are in the top quartile on a reliable and extensive measure of constructivist teaching philosophy are very likely to have students make regular use of computers during class. More than 3/4 of such teachers have students use word processing programs regularly during class and a majority are regular users of at least one other type of software besides skill-based games. In addition, other factors-such as an orientation towards depth rather than breadth in their teaching(perhaps caused by limited pressures to cover large amounts of content) and block scheduling structures that provide for long class periods-are also associated with greater use of computers by students during class. Finally, the paper provides evidence that certain approaches to using computers result in students taking greater initiative in using computers outside of class time-approaches consistent with a constructivist teaching philosophy, rather than a standards- based, accountability-oriented approach to teaching. Thus, despite their clear minority status as a primary resource in academic subject classroom teaching, computers are playing a major role in at least one major direction of current instructional reform efforts.

OBJETIVO: O estudo analisou a volumetria hepática por tomografia axial computadorizada, através de um programa informatizado semi-automático de aquisição e processamento de imagens digitalizadas, como parâmetro de acompanhamento da regeneração hepática em suínos, após hepatectomia parcial. MÉTODO: Doze suínos fêmeas, da raça Landrace, jovens, foram distribuídos em 3 grupos, conforme tempo de observação após o procedimento cirúrgico: 5(G5), 10(10) ou 15(G15) dias. Todos foram submetidos à hepatectomia parcial e, posteriormente, após acompanhamento, sacrificados, procedendo-se a retirada do fígado regenerado. A peça da hepatectomia e o fígado regenerado foram pesados e submetidos à realização da tomografia e aferição do volume através do software HEPATO®. Para análise estatística foram utilizados os testes não-paramétricos de Kruskal-Wallis e Wilcoxon. Valores de p