Search

Your search keyword '"León, Jorge"' showing total 19 results
Start Over Author "León, Jorge" Language portuguese
19 results on '"León, Jorge"'

2. Queilite acti'nica com displasia leve: relato de caso cli'nico.

Author

MAREGA, Naiara Alves, BUFALINO, Andreia, NAVARRO, Cláudia Maria, LEÓN, Jorge Esquiche, BARBEIRO, Camila de Oliveira, PALAÇON, Mariana Paravani, CAMARGO, Héric de Souza, and MASSUCATO, Elaine Maria Sgavioli

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

3. Penfigoide benigno das membranas mucosas em adolescente.

Author

de OLIVEIRA, Déborah Dayely Silveira, CAMARGO, Héric de Souza, LEÓN, Jorge Esquiche, BARBEIRO, Camila de Oliveira, MASSUCATO, Elaine Maria Sgavioli, and NAVARRO, Cláudia Maria

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

4. Carcinoma de células escamosas em mulheres idosas não fumantes: relato de três casos clínicos.

Author

NUNES, Carolina da Silva, BUFALINO, Andreia, NAVARRO, Cláudia Maria, LEÓN, Jorge Esquiche, BARBEIRO, Camila de Oliveira, PALAÇON, Mariana Paravani, CAMARGO, Héric de Souza, and MASSUCATO, Elaine Maria Sgavioli

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

5. EL TURISMO COMUNITARIO COMO ESTRATEGIA PARA LA VISIBILIZACIÓN Y REVALORIZACIÓN DE LA MEMORIA MUSICAL LOS PUEBLOS KICHWAS DE IMBABURA.

Author

Bastidas, Nhora Magdalena Benítez, León, Jorge Iván Albuja, and Orellana, Cristina Vaca

Abstract

Copyright of TURyDES is the property of TURYDES and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016

6. Lipomatose infiltrativa afetando a maxila.

Author

Ragusa da SILVA, Paula Verona, CALIENTO, Rubens, Albergoni da SILVEIRA, Heitor, Vilela da SILVA, Evanio, Biliato JAVARONI, Julia, Torres REYES, Magdalena Raquel, and Esquiche LEÓN, Jorge

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

7. Resolução de eosinofilia sanguínea e abertura de boca limitada após biópsia em um caso pediátrico de histiocitose de células de langerhans.

Author

Pimentel GONÇALVES, Bruna, Torres REYES, Magdalena Raquel, Biliato JAVARONI, Julia, Milhomens NOGUEIRA, Gustavo, Alas de LEÓN, Anyeli Soraya, Maria Cuadra ZELAYA, Florence Juana, Albergoni da SILVEIRA, Heitor, and Esquiche LEÓN, Jorge

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

8. Fibrohistiocitoma pseudosarcomatoso afetado a maxila: a importância da correlação clinicopatológica.

Author

Silva dos SANTOS, Larissa Witzel, de Oliveira BARBEIRO, Camila, Ragusa da SILVA, Paula Verona, BUFALINO, Andreia, Albergoni da SILVEIRA, Heitor, Vilela da SILVA, Evânio, and Esquiche LEÓN, Jorge

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

9. Papulose linfomatoide angioinvasiva "tipo E" afetando a cavidade oral: relato de caso detalhado e revisão da literatura.

Author

Albergoni da SILVEIRA, Heitor, Pimentel GONÇALVES, Bruna, Ragusa da SILVA, Paula Verona, Vila da SILVA, Evânio, BUFALINO, Andreia, and Esquiche LEÓN, Jorge

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

10. Actinomicose lingual clinicamente simulando neoplasia: relato de caso.

Author

Torres REYES, Magdalena Raquel, Biliato JAVARONI, Julia, Lopes DOMINGUETE, Matheus Henrique, Andrade GOMES, Diego, Ferreira DA SILVA, Anderson Tangerino, and Esquiche LEÓN, Jorge

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

11. Sialadenoma papilífero clássico afetando palato duro: relato de caso.

Author

Torres REYES, Magdalena Raquel, BUFALINO, Andreia, Oliveira BARBEIRO, Camila, Vilela DA SILVA, Evânio, Albergoni DA SILVEIRA, Heitor, and Esquiche LEÓN, Jorge

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

12. Concomitante apresentação de tatuagem por amálgama e lesão elastofibromatosa na cavidade oral: relato de caso.

Author

Nunes da SILVA, Kamila, Vilela da SILVA, Evânio, Ragusa da SILVA, Paula Verona, Biliato JAVARONI, Julia, Albergoni da SILVEIRA, Heitor, and Esquiche LEÓN, Jorge

Abstract

Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

13. Análise clinicopatológica e imunohistoquímica do carcinoma de células escamosas de células fusiformes da língua: um caso raro.

Author

Bezerra Silva, Diego Filipe, de Pontes Santos, Hellen Bandeira, Esquiche León, Jorge, de Castro Gomes, Daliana Queiroga, Muniz Alves, Pollianna, and Weege Nonaka, Cassiano Francisco

Abstract

Spindle cell squamous cell carcinoma of the tongue is a rare variant of squamous cell carcinoma. This paper reports the case of a spindle cell squamous cell carcinoma of the tongue, in a 64-year-old male patient, and presents a review of the etiopathogenesis, clinicopathological and immunohistochemical features and treatment of the malignancy. The patient presented for evaluation of a painful swelling on his tongue. Extraoral examination revealed palpable submandibular and superior cervical lymph nodes. Based on the presumptive diagnoses of squamous cell carcinoma or malignant salivary gland neoplasm, an incisional biopsy was performed. Histopathological analysis showed a proliferation of atypical spindle cells, exhibiting extensive pleomorphism. Tumor cells were positive for vimentin, P53 and alpha-smooth muscle actin, focally positive for epithelial membrane antigen and P63, and negative for pan-cytokeratin (AE1/AE3), CK7, CD138, CD34, CD56, and S-100. The positivity index for Ki-67 was approximately 40%. The diagnosis of spindle cell squamous cell carcinoma was established and the patient was referred to a head and neck surgery service. In the oral cavity, spindle cell squamous cell carcinoma of the tongue is an aggressive variant of squamous cell carcinoma, which usually presents as an exophytic mass located on the tongue of elderly males. Due to its distinct histopathological characteristics, immunohistochemistry is a valuable and helpful tool to establish the diagnosis of spindle cell squamous cell carcinoma of the tongue. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

15. Indoleamine 2,3 dioxygenase expression in oral and lower lip squamous cells carcinoma, leukoplakia and actinic cheilitis

Author

Lança, Maria Leticia de Almeida [UNESP], Universidade Estadual Paulista (Unesp), León, Jorge Esquiche, and Navarro, Cláudia Maria [UNESP]

Subjects
Imuno-Histoquímica, Diagnóstico, Carcinoma, Diagnosis, Immunohistochemistry
Abstract

Submitted by Maria Leticia De Almeida Lança (mlalanca@gmail.com) on 2020-07-16T17:02:22Z No. of bitstreams: 1 Dissertação mestrado.pdf: 1896754 bytes, checksum: 82c49a3fa8f8419b0abd33c8c751dec4 (MD5) Rejected by Ceres Maria Carvalho Galvão de Freitas null (ceres@foar.unesp.br), reason: Boa tarde, Maria Letícia!! Há correções a serem feitas: . Folha de rosto = faltou o coorientador (ver na ficha catalográfica). Se ele não for da Unesp, na hora de preencher no Repositório não coloque [UNESP] após o nome . Sumário = os ítens e subítens do Sumário devem estar iguais no texto. Verifique todos A numeração que consta no SUMÁRIO não está batendo com a do texto (indique só o 9 para paginação no Sumário da INTRODUÇÃO (NÃO 09)). No Repositório quando for preencher o número de financiamento, só cita o número do processo da Fapesp. 001 não é o número do processo da Capes. on 2020-07-17T20:16:57Z (GMT) Submitted by Maria Leticia De Almeida Lança (mlalanca@gmail.com) on 2020-07-22T18:50:08Z No. of bitstreams: 1 Dissertação MLAL.pdf: 1896501 bytes, checksum: 97980c6a5d6891cf59b82144b2d28096 (MD5) Rejected by Ceres Maria Carvalho Galvão de Freitas null (ceres@foar.unesp.br), reason: Bom dia!! SUMÁRIO e ítens do Sumário no texto continuam diferentes. Tem que estar escritos do mesmo modo (singular/plural, maiúscula/minúscula, abreviaturas.....) No SUMÁRIO: ítem 2 OBJETIVOS (em maiúsculo). No texto colocar o ítem 2 e os subítens no plural Observar no texto subítens 3.2,3.3, 3.4, 3.5 com o Sumário No ítem 5 do SUMÁRIO você não descreveu os subítens 5.1, 5.2, 5.3, 5. on 2020-07-23T13:55:47Z (GMT) Submitted by Maria Leticia De Almeida Lança (mlalanca@gmail.com) on 2020-07-28T18:07:34Z No. of bitstreams: 1 Dissertação MLALança.pdf: 1898490 bytes, checksum: 7710e4b216df6943bc662fd37c78547e (MD5) Approved for entry into archive by Ceres Maria Carvalho Galvão de Freitas null (ceres@foar.unesp.br) on 2020-07-29T17:02:47Z (GMT) No. of bitstreams: 1 lança_mla_me_arafo.pdf: 1877407 bytes, checksum: 67566ea4920d72f631a3c2c656ec29c0 (MD5) Made available in DSpace on 2020-07-29T17:02:47Z (GMT). No. of bitstreams: 1 lança_mla_me_arafo.pdf: 1877407 bytes, checksum: 67566ea4920d72f631a3c2c656ec29c0 (MD5) Previous issue date: 2020-03-18 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) A indoleamina 2,3-dioxigenase (IDO) é uma enzima com efeito imunossupressor e a sua expressão no microambiente tumoral auxilia a fuga imune das células tumorais. Neste estudo, determinamos e associamos a expressão de IDO em carcinoma espinocelular (CEC) intraoral e labial, leucoplasia oral (LO) e queilite actínica (QA). Métodos: análise morfológica e imuno-histoquímica foi realizada em espécimes de CEC intraoral (n = 21), CEC labial (n = 20), LO (n = 24) e QA (n = 20). As amostras de LO e QA foram classificadas, morfologicamente, de acordo com a ausência ou presença de displasia de alto e baixo grau. As amostras de CEC foram morfologicamente classificadas de acordo com a OMS. Resultados: a expressão de IDO foi observada em células epiteliais neoplásicas e não-neoplásicas, bem como em células imunes. Todos CEC orais e apenas 30% dos casos de CEC labiais expressaram IDO. Nos grupos LO e QA, 71% e 25% dos casos foram positivos para IDO, respectivamente. O CEC intraoral apresentou o maior número de amostras positivas com alta expressão de IDO, seguido pela LO com displasia de alto grau. Conclusões: O CEC intraoral apresenta alta expressão de O, o que, possivelmente, fomenta o seu comportamento mais agressivo e pior progn stico em relação ao CEC labial, que apresenta pouca expressão de IDO. A IDO atuaria, indicando uma progressão tumoral, mais especificamente para a LO do para a QA, pois a LO com displasia de alto grau expressou mais IDO em relação a de baixo grau. Indoleamine 2,3-dioxigenase (IDO) is an enzyme with an immunosuppressive effect and its expression in the tumor microenvironment helps the immune escape of tumor cells. In this study, we determined and associated the expression of IDO in squamous cell carcinoma (SCC) oral and labial, oral leukoplakia (OL) and actinic cheilitis (AC). Methods: morphological and immunohistochemical analysis was performed on specimens of oral SCC (n = 21), labial SCC (n = 20), OL (n = 24) and AC (n = 20). OL and AC samples were classified, morphologically, according to the absence or presence of high and low grade dysplasia. The SCC samples were morphologically classified according to the WHO. Results: the expression of IDO was observed in neoplastic and non-neoplastic epithelial cells, as well as in immune cells. All oral SCC and only 30% of cases of lip SCC expressed IDO. In the OL and AC groups, 71% and 25% of the cases were positive for IDO, respectively. The oral SCC presented the highest number of positive samples with high expression of IDO, followed by OL with a high degree of dysplasia. Conclusions: oral SCC has a high expression of IDO, which, possibly, promotes its more aggressive behavior and worse prognosis in relation to lip SCC, which presents little expression of IDO. IDO would act indicating a tumor progression, more specifically for OL than for AC, as OL with high-grade dysplasia expressed more IDO compared to low-grade. CAPES: 001. FAPESP: 11/52090-8

Published
2020

16. Comparative immunohistochemistry characterization of subgroups of dendritic cells and viral oncogenesis in oral and oropharyngeal squamous cell carcinomas

Author

Silveira, Heitor Albergoni, Universidade Estadual Paulista (Unesp), and León, Jorge Esquiche

Subjects
Células dendríticas, Boca, Squamous cell carcinoma, Dendritic cells, Imuno-histoquímica, Carcinoma de células escamosas, Orofaringe, Papillomaviridae, Immunohistochemistry
Abstract

Submitted by Heitor Albergoni da Silveira (heitor.albergoni@unesp.br) on 2020-03-19T15:20:31Z No. of bitstreams: 1 Dissertação mestrado HEITOR repositório.pdf: 17277362 bytes, checksum: 5a7b1b31f3e149c9bff9a7d9092919d8 (MD5) Submitted by Heitor Albergoni da Silveira (heitor.albergoni@unesp.br) on 2020-03-19T15:20:31Z No. of bitstreams: 1 Dissertação mestrado HEITOR repositório.pdf: 17277362 bytes, checksum: 5a7b1b31f3e149c9bff9a7d9092919d8 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Submitted by Heitor Albergoni da Silveira (heitor.albergoni@unesp.br) on 2020-03-19T15:20:31Z No. of bitstreams: 1 Dissertação mestrado HEITOR repositório.pdf: 17277362 bytes, checksum: 5a7b1b31f3e149c9bff9a7d9092919d8 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Submitted by Heitor Albergoni da Silveira (heitor.albergoni@unesp.br) on 2020-03-19T15:20:31Z No. of bitstreams: 1 Dissertação mestrado HEITOR repositório.pdf: 17277362 bytes, checksum: 5a7b1b31f3e149c9bff9a7d9092919d8 (MD5) Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Submitted by Heitor Albergoni da Silveira (heitor.albergoni@unesp.br) on 2020-03-19T15:20:31Z No. of bitstreams: 1 Dissertação mestrado HEITOR repositório.pdf: 17277362 bytes, checksum: 5a7b1b31f3e149c9bff9a7d9092919d8 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Submitted by Heitor Albergoni da Silveira (heitor.albergoni@unesp.br) on 2020-03-19T15:20:31Z No. of bitstreams: 1 Dissertação mestrado HEITOR repositório.pdf: 17277362 bytes, checksum: 5a7b1b31f3e149c9bff9a7d9092919d8 (MD5) Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Approved for entry into archive by Marley Cristina Chiusoli Montagnoli (marley@foar.unesp.br) on 2020-03-19T17:22:08Z (GMT) No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Made available in DSpace on 2020-03-19T17:22:08Z (GMT). No. of bitstreams: 1 silveira_ha_me_arafor_par.pdf: 413773 bytes, checksum: 9de259336dcf140d90bdd337470bba80 (MD5) Previous issue date: 2020-02-19 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) O carcinoma espinocelular (CEC) de cabeça e pescoço (CECCP) é o quinto tipo de câncer mais comum e a sexta causa de morte por câncer. Recentes estudos enfatizam o CEC oral (CECO) como uma entidade distinta do CEC de orofaringe (CECorof), com este último apresentando melhor prognóstico e estreitamente associado com infecção pelo papilomavírus humano (HPV). A etiologia do CECCP é multifatorial; porém, o CECO está relacionado com abuso do tabaco e álcool, enquanto o CECorof está frequentemente associado com infecção pelo HPV. As células dendríticas (CDs) são importantes células as quais regulam repostas imunes, incluindo aquelas vinculadas à tumorigênese, estabelecendo conexão entre o sistema imune inato e adaptativo. Estão divididas em dois grupos: CDs mieloides (CDmi) e CDs plasmocitóides (CDp), incluindo CDs imaturas (CDim) e CDs maduras (CDm). O objetivo do nosso estudo foi analisar comparativamente, através da técnica de imunoistoquímica (IQ) e hibridização in situ (HIS), a infiltração de CDmi e CDp, incluindo subgrupos de CDim e CDm, no CECO (n=109) e CECorof (n=126), bem como analisar a oncogênese viral (HPV amplo espectro, alto risco (ARHPV) e baixo risco (BRHPV) oncogênico e vírus Epstein-Barr [VEB]) por HIS. O CECOrof (25%) comparado com o CECO (11%) mostrou associação significativa com o HPV. No CECorof e no CECO, 19 e 7 mostram positividade para ARHPV (somente), 6 e 3 BRHPV (somente) e 3 e 2 ARHPV/BRHPV (co-infecção), respectivamente. Os tumores HPV-positivos comparados com os HPV-negativos apresentaram índice proliferativo significativamente maior através dos marcadores Ciclina D1 e Ki-67. O CECO associado ao ARHPV e ao BRHPV apresentou maior taxa de sobrevida global. No geral, os marcadores para imDC, foram significativamente mais frequentes no CECorof do que no CECO. Diferentemente, CECO e CECorof apresentaram maior número de marcadores de CDs submucosas (CDsub). Ambas as neoplasias apresentaram quantidades semelhantes de CDp ativadas. O grupo HPV+ mostrou um número maior de CDs em ambas as neoplasias do que o grupo HPV-. Vale ressaltar que um número significativamente maior de células CD207+ e CD123+ foi observado no CECorof HPV+ do que no CECO HPV+. Concluimos que diferente do CECO, nossos resultados mostram no CECorof predominância de CDim, com perfil de ativação de células imunes. A presença do HPV parece mostrar associação com a infiltração de CDs em ambas as neoplasias, sugerindo respostas imunes antivirais no CECorof HPV+. Head and neck squamous cell carcinoma (SCC) (HNSCC) is the fifth most common type of cancer and the sixth leading cause of cancer death. Recent studies emphasize oral SCC (OSCC) as an entity distinct from oropharyngeal SCC (OPSCC), with the latter having a better prognosis and closely associated with human papillomavirus (HPV) infection. The etiology of HNSCC is multifactorial; however, OSCC is related to tobacco and alcohol abuse, while OPSCC is often associated with HPV infection. Dendritic cells (DCs) are important cells that regulate immune responses, including those linked to tumorigenesis, establishing a connection between the innate and adaptive immune systems. They are divided into two groups: myeloid DCs (myCD) and plasmacytoid DCs (pDC), including immature DCs (imDC) and mature CDs (mDC). The aim of our study was to comparatively analyze, through the immunohistochemistry (HIS) and in situ hybridization (ISH) technique, the infiltration of myCD and pDC, including subgroups of imDC and mDC, in the OSCC (n= 109) and OPSCC (n= 126), as well as analyzing viral oncogenesis (wide-spectrum HPV, high-risk (HRHPV) and low-risk (LRHPV) oncogenic and Epstein-Barr virus [EBV]) by ISH OPSCC (25%) compared to OSCC (11%) showed a significant association with HPV. In OPSCC and OSCC, 19 and 7 shows positivity for HRHPV (only), 6 and 3 LRHPV (only) and 3 and 2 HRHPV/LRHPV (co-infection), respectively. HPV-positive tumors compared to HPV-negative tumors showed a significantly higher proliferative index through the cyclin D1 and Ki-67 markers. The OSCC associated with HRHPV and LRHPV had the highest overall survival rate. Overall, markers for imDC were significantly more frequent in OPSCC than in OSCC. In contrast, OSCC and OPSCC had a higher number of subDC markers. Both neoplasms showed similar amounts of activated pCD. The HPV group showed a greater number of CDs in both neoplasms than the HPV-. It is noteworthy that a significantly higher number of CD207+ and CD123+ cells was observed in HPV-associated OPSCC than in HPV-associated OSCC. We concluded that unlike OSCC, our results show a predominance of imDCs, with an activation profile of immune cells, in OPSCC. The HPV status seems to show an association with the infiltration of DCs in both neoplasms, suggesting antiviral immune responses in the OPSCC associated with HPV. Keywords: 18/12734-2 16/11419-0

Published
2020

17. Interação de componentes celulares estromais e microvasculares em tumor odontogênico queratocístico: um estudo comparativo

Author

Sousa Neto, Ernesto Santos, Santos, Jean Nunes dos, dos Santos, Jean Nunes, Rocha, Clarissa Araújo Gurgel, and León, Jorge Esquiche

Subjects
Alfa-SMA, Ciências da Saúde, D2-40, Mastócitos, Mast cell triptase, Macrófagos, CD163, Miofibroblastos, CD34, Tumor odontogênico queratocístico, Índice angiogênico
Abstract

Submitted by Programa de Pós-Graduação em Odontologia Saúde (mestrodo@ufba.br) on 2017-04-03T14:12:58Z No. of bitstreams: 1 PDF Final.pdf: 4765427 bytes, checksum: ae3f93ce46ff32b7ce466869740090de (MD5) Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2017-06-29T14:28:32Z (GMT) No. of bitstreams: 1 PDF Final.pdf: 4765427 bytes, checksum: ae3f93ce46ff32b7ce466869740090de (MD5) Made available in DSpace on 2017-06-29T14:28:32Z (GMT). No. of bitstreams: 1 PDF Final.pdf: 4765427 bytes, checksum: ae3f93ce46ff32b7ce466869740090de (MD5) FAPESB O presente trabalho teve como objetivo estudar, por meio da imunohistoquímica, a participação de componentes celulares estromais a exemplo dos mastócitos (mast cell triptase), miofibroblastos (alfa-SMA) e macrófagos (CD163) e componentes vasculares (CD34 e D2-40) em uma série de tumores odontogênicos queratocísticos (TOQ), na tentativa de fornecer subsídios para compreender a interação entre esses componentes e o comportamento biológico distinto desta lesão. Para fins comparativos, cistos radiculares (CRs) e folículos pericoronários (FPs) também foram incluídos. A amostra foi composta por 30 TOQs, 15 CRs e 07 FPs. Para a avaliação dos mastócitos, miofibroblastos e macrófagos, foram quantificadas as células imunorreativas aos marcadores mast cell triptase, alfa-SMA e CD163, respectivamente, em 10 campos (400x). Os índices angiogênico e linfangiogênico foram avaliados por meio da densidade microvascular (MVD) e densidade microvascular linfática (MVDL) dos microvasos marcados, respectivamente, pelos marcadores CD34 e D2- 40. Foi utilizado o teste ANOVA com pós-teste de correção de Tukey, para análise estatística entre os marcadores segundo o tipo de lesão. Para a análise da correlação entre os marcadores dentro da mesma lesão, utilizamos a correlação de Pearson. Para a associação, no TOQ, entre os marcadores e a presença de inflamação, utilizamos o Teste T de Student. A análise da expressão do marcador mast cell triptase revelou existir diferenças significativas (p0,05). A respeito dos macrófagos, não houve diferenças significativas (p= 0,084) entre as densidades de macrófagos presentes nos TOQs (2,31), CRs (1,42) e FPs (0,14). Na avaliação do índice angiogênico, não houve diferenças significativas da MVD entre as três lesões estudadas. No entanto, para o índice linfangiogênico, houve diferença significativa (p0,05). Não foi encontrada associação significativa (p>0,05) entre os marcadores estudados com a presença de inflamação no TOQ. No presente trabalho, encontramos uma correlação positiva e moderada entre os marcadores mast cell triptase e o CD34 nos TOQ (p = 0,025). Já nos CRs encontramos uma correlação inversa e moderada entre os marcadores SMA x CD34 (p = 0,017). Nos FPs também encontramos uma correlação inversa entre os mesmos marcadores anteriores, porém forte (p=0,049). Embora os componentes celulares estromais e microvasculares aqui representados por mastócitos, miofibroblastos, macrófagos CD163 positivos e vasos CD34 e D240, respectivamente, sejam importantes para manutenção do arcabouço estrutural do TOQ e CR, existiu uma interação significante entre mast cell triptase e CD34 no TOQ e entre CD34 e o alfa –SMA no CR. The present study aimed to investigate, by immunohistochemistry, the participation of stromal cell components such mast cell (mast cell tryptase), myofibroblasts (alpha- SMA) and macrophages (CD163) and vascular components (CD34 and D2-40) in a series of keratocysts odontogenic tumors (OKT) in an attempt to provide information to understand the interaction between these components and the biological behavior of this lesion. For comparative purposes, radicular cysts (RCs) and pericoronal follicles (PFs) were also included. The sample comprised 30 OKTs, 15 RCs and 07 PFs. For the evaluation of mast cells, myofibroblasts and macrophages, the cells immunoreactive with biomarkers mast cell tryptase, alpha- SMA and CD163 were quantified, respectively, in 10 fields (400x). The angiogenic and lymphangiogenic index were assessed by microvessel density (MVD) and lymphatic microvessel density (MVDL) of microvessels marked respectively by for CD34 and D2-40. ANOVA with post-test Tukey correction for statistical analysis between markers was used according to the type of injury. To analyze the correlation between markers within the same lesion, we used the Pearson correlation. For the association, the OKT between markers and the presence of inflammation, we used the Student's t test. The analysis of expression of mast cell tryptase shows any significant differences (p < 0.05) between the density of mast cells present in RCs (22.7) than FPs (1.23) and TOQs (7.39) and the density of mast cells present in TOQs and FPs. There was also a significant difference (P < 0.05) between the density of myofibroblasts in TOQs (29.25) compared to CRs (4.66) and FPs (1.50). The difference in density between the RCs of myofibroblasts and PFs was not significant (p> 0.05). With respect to macrophages, no significant differences (p = 0.084) between the densities of macrophages present in TOQs (2.31), CR (1.42) and FPs (0.14). With respect to the angiogenic index, there were no significant differences in MVD between the three lesions studied. However, for the lymphangiogenic index, a significant difference (p < 0.05) between MVDL present in TOQs (11.64) compared to CRs (4.19) and FPs (0.167). The difference between MVDL of CRs compared to FPs was not statistically significant (p > 0.05). No significant association (p > 0.05) between the biomarkers studied in the presence of inflammation in the OKT was found. In the present study, we found a moderate positive correlation between mast cell tryptase and CD34 markers in OKT (p = 0.025). Have the CR and found an inverse correlation between moderate SMA x CD34 (p = 0.017). In PFs also found an inverse correlation between the SMA x CD34, but strong (p = 0.049). Although stromal microvascular and cellular components represented here by mast cells, myofibroblasts, and CD163 positive macrophages and vessels CD34 and D240 are important for maintaining the structural framework of the OKT and RC, a significant interaction between mast cell tryptase x CD34 existed in OKT and between CD34 x alpha- SMA in RC.

Published
2014

18. Comparative analysis of clinicopathologic and immunohistochemical features of gingival cyst of adult, lateral periodontal cyst and glandular odontogenic cyst

Author

Mário José Romañach, Pires, Fábio Ramôa, Gomez, Ricardo Santiago, León, Jorge Esquiche, Almeida, Oslei Paes de, Vargas, Pablo Agustin, Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba, Programa de Pós-Graduação em Estomatopatologia, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Queratinas, Odontogenic cysts, Keratins, Cistos odontogênicos
Abstract

Orientador: Fábio Ramôa Pires Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba Resumo: Cistos gengival do adulto (CGA), periodontal lateral (CPL) e odontogênico glandular (COG) são cistos odontogênicos raros que apresentam características microscópicas similares e comportamento clínico distinto. O objetivo deste trabalho foi comparar o perfil clínico-patológico e imunoistoquímico de 45 casos destes três tipos de cistos odontogênicos (CGA = 14, CPL = 15, COG = 16) oriundos de 4 diferentes laboratórios de Patologia Oral. Os CGAs acometeram principalmente na gengiva da região de pré-molares inferiores de mulheres com média de idade de 56 anos. Os CPLs acometeram principalmente as regiões anterior e de pré-molares da mandíbula de mulheres com média de idade de 54 anos. Os COGs acometeram principalmente a região de molares mandibulares de mulheres com média de idade de 50 anos. Microscopicamente, epitélio com espessura maior que 5 camadas contendo estruturas intra-epiteliais pseudo-ductais, células colunares e mucosas foram observadas predominantemente nos COGs quando comparados aos CGAs e CPLs. A positividade para CK 5 e CD138 foi encontrada principalmente nas camadas basal e intermediária enquanto que CKs 8 e 19 marcaram as camadas intermediária e superficial dos três tipos de cistos. COGs apresentaram índice de positividade para p63 aumentado (59%) em relação aos encontrados em CGAs (26%) e CPLs (48%). A cápsula de COGs mostrou maior positividade para actina de músculo liso-alfa e CD138 quando comparada aos CPLs e CGAs. Concluimos que CGA, CPL e COG possuem características histopatológicas e imunoistoquímicas similares que podem justificar uma provável origem comum Abstract: Gingival cyst of adult (GCA), lateral periodontal cyst (LPC) and glandular odontogenic cyst (GOC) are rare odontogenic cysts that present similar microscopic features and distinct clinical behavior. The aim of the present study was to compare the clinicopathological and immunohistochemical profile of 45 cases of these 3 types of odontogenic cysts (GCA = 14, LPC = 15, GOC = 16) from 4 different Oral Pathology laboratories. GCA mainly affected the gingiva of the lower pre-molars region of women with median age of 56 years-old. LPC mainly affected the anterior and pre-molars regions of the mandible of women with median age of 54 years-old. GOC mainly affected the mandibular molars region of women with median age of 50 years-old. Microscopically, epithelium with more than 5 layers containing duct-like intraepithelial structures and colunar and mucous cells were predominantly observed in GOC when compared to GCA and LPC. The positivity for CK 5 and CD138 was mainly observed in the basal and intermediate layers while CK 8 and CK 19 staining was seen in the intermediate and superficial layers of the cystic epithelium in all cysts. GOC presented higher p63 positivity index (59%) comparing with those found in GCA (26%) and LPC (48%). The connective tissue capsule of GOC exhibited higher positivity for smooth muscle actin and CD138 when comparing with GCA and LPC. We conclude the GCA, LPC and GOC share similar microscopic and immunohistochemical features that could justify a likely common origin Doutorado Patologia Doutor em Estomatopatologia

Published
2011

19. Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case.

Author

Silva DFB, Santos HBP, León JE, Gomes DQC, Alves PM, and Nonaka CFW

Subjects
Diagnosis, Differential, Humans, Immunohistochemistry, Male, Middle Aged, Carcinoma, Squamous Cell pathology, Tongue Neoplasms pathology
Abstract

Spindle cell squamous cell carcinoma of the tongue is a rare variant of squamous cell carcinoma. This paper reports the case of a spindle cell squamous cell carcinoma of the tongue, in a 64-year-old male patient, and presents a review of the etiopathogenesis, clinicopathological and immunohistochemical features and treatment of the malignancy. The patient presented for evaluation of a painful swelling on his tongue. Extraoral examination revealed palpable submandibular and superior cervical lymph nodes. Based on the presumptive diagnoses of squamous cell carcinoma or malignant salivary gland neoplasm, an incisional biopsy was performed. Histopathological analysis showed a proliferation of atypical spindle cells, exhibiting extensive pleomorphism. Tumor cells were positive for vimentin, P53 and alpha-smooth muscle actin, focally positive for epithelial membrane antigen and P63, and negative for pan-cytokeratin (AE1/AE3), CK7, CD138, CD34, CD56, and S-100. The positivity index for Ki-67 was approximately 40%. The diagnosis of spindle cell squamous cell carcinoma was established and the patient was referred to a head and neck surgery service. In the oral cavity, spindle cell squamous cell carcinoma of the tongue is an aggressive variant of squamous cell carcinoma, which usually presents as an exophytic mass located on the tongue of elderly males. Due to its distinct histopathological characteristics, immunohistochemistry is a valuable and helpful tool to establish the diagnosis of spindle cell squamous cell carcinoma of the tongue.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results