Background: Exogenous drug intoxication is one of the main public health problems. This aggravation caused by self-medication, its incorrect and unnecessary use, as well as its bad administration, causes from chemical dependence and bacterial resistance to death. Objective: The objective of this study is to outline an epidemiological profile of exogenous intoxications in the Northeast, during the period from 2008 to 2017. Methods: This is a descriptive and retrospective epidemiological study, carried out from the data provided by the Information System of Notifiable Diseases (Sinan), obtained by tabbing TABWIN of the platform of the Department of Informatics of the Unified System of SUS (Datasus), and of the Brazilian Institute of Geography and Statistics (IBGE). Results: There was a predominance of female (66.36%), mixed race (82.4%) people, with low education, above all, elementary school (52.8%), aged 15- 39 years (51.15%) or 1-4 years (14.17%) and residents of the urban region (86.42%). The main circumstance was attempted suicide (48.66%), and most events were acute-single (90.12%), evolved with no sequela cure (97.94%), clinical diagnosis was performed (72, 2%) and there was confirmation of intoxication (76.67%). There was a continuous increase in the incidence rate for exogenous intoxications due to medications in the Northeast, during the period from 2008 to 2017, with a total increase of 437.68%, and in 2017 this rate was found in 20.6 cases per 100,000 inhabitants. It was found that the capitals had higher incidence rates than their respective states. Conclusion: Thus, health surveillance, inspection, promotion and prevention measures are necessary, aiming to reduce these serious and potentially preventable cases. [ABSTRACT FROM AUTHOR]