1. [Jejunal myenteric denervation induced by benzalkonium chloride].
- Author
-
Ramalho FS, Santos GC, Ramalho LN, Kajiwara JK, and Zucoloto S
- Subjects
- Animals, Case-Control Studies, Male, Rats, Rats, Wistar, Time Factors, Benzalkonium Compounds pharmacology, Jejunum innervation, Muscle Denervation, Myenteric Plexus drug effects
- Abstract
The effects of benzalkonium chloride (BAC) on the number of myenteric neurons, muscle thickness and external perimeter after acute (until 10 days after BAC application) and chronic (30 and 60 days after BAC application) denervation of the proximal jejunum were determined in rats. There was a significant reduction in the number of myenteric neurons of all segments treated with BAC. The extent of denervation varied along the time, and it was reduced in the denervated segments of the chronic group in comparison with the acute group. This may be due to the neuroplasticity phenomenon appearing during the chronic phase. Myenteric denervation increased the thickness of the propria muscle layer, especially in the longitudinal muscle layer, suggesting a higher sensitivity of this layer to myenteric denervation.
- Published
- 1994