1. [Intracranial saccular aneurysms: experimental evaluation of intravascular therapeutic procedures].
- Author
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Siqueira MG, Vieira IA, Cilião EA, and Guerra DM
- Subjects
- Animals, Bucrylate pharmacology, Catheterization, Dogs, Injections, Intra-Arterial, Intracranial Aneurysm diagnostic imaging, Intracranial Aneurysm pathology, Radiography, Bucrylate administration & dosage, Carotid Arteries, Cyanoacrylates administration & dosage, Embolization, Therapeutic methods, Intracranial Aneurysm therapy
- Abstract
Studies were performed on adult mongrel dogs to evaluate the possibility of occluding saccular aneurysms with an intravascular injection of the tissue adhesive Bucrylat (isobutyl-2-cyanoacrylate). Fourteen surgically constructed carotid aneurysms were occluded by the injection of Bucrylat through a fluoroscopically positioned intra-arterial catheter. Angiography performed immediately before and after injection and up to 1 month following treatment revealed progressive and persistent occlusion of the aneurysms. The specimens examined histologically 1 month after the injection showed an endothelialized fibrous tissue bridge crossing the neck of the aneurysm what appear to indicate a permanent occlusion of the structures treated. A similar approach to treat intracranial aneurysms will depend on advances in the field of selective intracranial catheterization that will permit safe and accurate catheterization of the aneurysm sac.
- Published
- 1980
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