1. [PPARs: physiological functions and pharmacological roles of agonists in human diseases. Note II].
- Author
-
Filip-Ciubotaru F, Manciuc C, Grigore C, and Foia L
- Subjects
- Diabetes Mellitus, Type 2 drug therapy, Humans, PPAR alpha metabolism, PPAR alpha pharmacology, PPAR delta metabolism, PPAR delta pharmacology, PPAR gamma metabolism, PPAR gamma pharmacology, PPAR-beta metabolism, PPAR-beta pharmacology, Peroxisome Proliferator-Activated Receptors genetics, Thiazolidinediones therapeutic use, Lipid Metabolism drug effects, Peroxisome Proliferator-Activated Receptors metabolism, Peroxisome Proliferator-Activated Receptors pharmacology
- Abstract
Increasing attention paid to the main family of peroxisome proliferator activated receptors--PPARs is generated, on one hand by the multiple functions of its members in numerous metabolically active tissues, and on the other hand by the therapeutic benefits expresed by some specific ligands that are used in certain metabolic diseases treatment plan. PPARalpha stimulates the beta-oxidative degradation of fatty acids and controls plasma lipid transport through the mediated action upon the triglycerides and fatty acids metabolism and by modulation of biosynthesis and catabolism of bile acids in the liver. PPARgamma promotes adipocytes differentiation and fat storage. PPARbeta/delta is involved in control and management of adipogenesis. While PPARalpha mediates the hypolipemiant actions of fibrates, PPARgamma is the receptor for thiazolidinediones (glitazones) reccomended in type 2 diabetes treatment; by binding to PPARgamma, glitazones modulates transcription of genes involved in lipid and carbohydrate metabolism.
- Published
- 2012