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The SARS-CoV-2 virus has generated an unprecedented pandemic worldwide for the past 100 years. The healthcare systems have been profoundly challenged by the COVID-19 pandemic; also, tendencies of socio-economic and cultural changes have been observed during this period. One of the professions most affected by this pandemic is dentistry. For dental professionals, the explosion of information available online and through social networks sometimes generates uncertainty and identifying relevant scientific studies and guidelines, which allow the best decisions to be made in the professional activity, can be difficult. The moral obligation of all healthcare providers to care for their patients with the guiding principle of "primum non nocere" is very well known. In this context, national and international guidelines have been developed by accredited professional boards, to correctly inform dental professionals. The purpose of this paper is to identify and highlight the most relevant ethical and safety issues in Romania, which can be applied with confidence during the COVID-19 pandemic, but also in the future, to properly carry out our professional activity and show respect to our patients and to ourselves. [ABSTRACT FROM AUTHOR]

The off-label prescription means that medicines are administered by an unlicensed route, in an unlicensed formulation or dosage or to a child below the stated age range. The use of drugs in an off-label or unlicensed manner to treat children is widespread. Because many prescribed treatments for children have not been adequately tested in children, this population of patients remains a vulnerable one. On the one hand, prescribing off-label use drugs in children determines a lot of controversies but, one the other hand, without this possibility, could be deprived of a chance to be treated. The paper presents the widespread phenomenon of off-label us drugs in children, refl ecting in scientifi c studies in USA and Europe. An important focus is on Romanian statistic of Sildenafi l prescription and on dilemmatic use of it in pediatric cardiology unit. [ABSTRACT FROM AUTHOR]