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Genetic testing represents a major asset for discriminating between normal antigenic stimulation of B or T cells and malignant, pathological findings. The main difference between those two situations is the heterogenicity of lymphocyte populations as a result of diverse antigenic stimulation for the first situation, compared to single and identical population (clones) for the second situation. The present paper describes one of the many genetic assays capable of discriminating between normal and malignant, characterized by low time-to-result interval, accuracy, simplicity, and low cost comparing to other tests. [ABSTRACT FROM AUTHOR]

Monogenic autoinflammatory syndromes comprise disorders caused by mutations of different genes encoding for proteins that play a major role in the inflammatory response. They are characterized by seemingly unprovoked inflammatory episodes lacking high concentrations of autoantibodies or autoreactive T cells. The clinical spectrum of these syndromes are extremely variable and is represented by: recurrent fever episodes of variable duration (periodic/recurrent fever), skin lesions (cryopyrinopathies), noncaseating granulomas (granulomatous disorders) and, rarely, by sterile pyogen abscesses (pyogenic disorders). This paper represents a briefly presentation of these disorders. [ABSTRACT FROM AUTHOR]